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Minoxidil
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DRUG INFO
Minoxidil
Drug Name:
Minoxidil
Indication: Indicated in the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.
Pharmacology: Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. The predominant site of minoxidil action is arterial. Venodilation does not occur with minoxidil; thus, postural hypotension is unusual with its administration. The antihypertensive activity of minoxidil is due to its sulphate metabolite, minoxidil sulfate.
Mechanism Of Action: Minoxidil is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.
Drug Category: Vasodilator Agents; Antihypertensive Agents; Skin and Mucous Membrane Agents (84:92.00); ATC:C02DC01; ATC:D11AX01
Brand Names/Synonyms: Alopexil; Alostil; Apo-Gain; CHEMBANK82; Gen-Minoxidil; HSDB 6538; KC-125; Loniten; Lonolox; M142; Minodyl; Minossidile; Minossidile [Italian]; Minoxidil; Minoxidil [Usan:Ban:Inn]; Minoxidilum [Inn-Latin]; Minoxigaine; Minoximen; Normoxidil; PDP; Pierminox; Prexidil; Regaine; Rogaine; Rogaine Extra Strength for Men; Rogaine for Men; Rogaine for Women; Theroxidil; Triclosan; Tricoxidil; Trocoxidil
Dosage Forms: LIQUID, TABLET
Absorption: Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man.
Interactions: Interactions for Minoxidil:
Interaction with Guanethidine: Although minoxidil does not itself cause orthostatic hypotension, its administration to patients already receiving guanethidine can result in profound orthostatic effects. If at all possible guanethidine should be discontinued well before minoxidil is begun. Where this is not possible, minoxidil therapy should be started in the hospital and the patient should remain institutionalized until severe orthostatic effects are no longer present or the patient has learned to avoid activities that provoke them.
Chemical IUPAC Name: 3-hydroxy-2-imino-6-(1-piperidyl)-3H-pyrimidin-4-amine
Chemical Formula: C9H15N5O
Half Life: 4.2 hours
Drug Type: Approved Drug
# Accession No: APRD00086
CAS Registry Number: 38304-91-5
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Minoxidil News
(When available)
Stub it out . . risks from smoking will not just blow over 16 Jan 2006
Scotsman, Rubbing a medication called Regaine into your scalp every day can produce some hair growth but it is soft, downy hair and it drops out again if you stop the ...
Worse Than Being Bald Jan 12, 2006
CBS News ...of hair. Somehow I’ve never really been tempted by hair club or Rogaine or any of the stuff that promises a mane of glory. So ...
REVIEW : Bald! a reflection on the world’s superior heads Dec 25, 2005
Arkansas Democrat-Gazette (subscription), ...and Retin-A and Viagra and any number of scientific or pseudo-scientific attempts to stave off the Grim Reaper, not the least of which are Rogaine, the brand ...
A stadium by any other name isn't just as sweet Jan 12, 2006
Ottawa Sun, You'd have thought it was something important -- a cure for a horrible disease perhaps, or that Roy Mlakar was becoming the spokesman for Rogaine. ...
Hair loss in women is often a symptom of hidden but treatable ... Jan 4, 2006
Fort Lauderdale Sun Sentinel, ...the scalp. Like men, women can try minoxidil - better known by the brand name Rogaine - a liquid rubbed on twice a day. Some see ...
Bad new idea by city: 'stealth gala' Jan 6, 2006
Stockton Record, ...his cost; or his contract includes an embarrassing rider requiring that before every show a high school cheerleader massages a bong full of Rogaine into his ...
Donations to area thrift stores double; clothes, furniture stacked ... Jan 8, 2006
Press of Atlantic City, Some examples: A box of Rogaine; liquid plant food; a half-dozen cans of shaving cream; anti-aging vitamins; a Neneh Cherry cassette tape. ...
A STRUGGLE: BUT PROSSER HAPPY WITH WIN Deacons hang on Wake Forest ... Dec 22, 2005
Winston-Salem Journal, ..."What I've got left that's red is getting gray," Prosser said of his hair. "I know this team is determined to get me into the Rogaine camp by February. ...
Extra strength anything is king in the medicine aisle Dec 26, 2005
Naples Daily News (subscription), ...strength status. If Tootle wants to preserve his head of spiky bleached-blond hair, he might consider extra-strength Rogaine. (The ...
Taking The Brenalt Group to the Next Level Dec 19, 2005
Hispanic PR Wire (press release), John’s integrated brand management experience includes Microsoft, Rogaine, SONY, Sprint PCS, ALZA, Aciphex, US Army, MetLife, Nestle, The Discovery Channel ...
A year of triumph and tragedy By MICHAEL HOFFMAN Dec 24, 2005
The Japan Times, Unlike Pfizer Inc's Rogaine, another baldness remedy available over the counter in Japan (but in a lower density formulation than the US domestic variety ...
Ties Between Gang, Fences Probed Dec 23, 2005
Los Angeles Times, Caught with nearly $10,000 worth of Aleve, Rogaine, Pepsid AC and other medications, the suspects admitted targeting numerous Walgreens stores the previous day ...
Picking Splinters: The 2005 'Arbies' Dec 29, 2005
Falls Church News Press, My Rogaine Comeback of the Year Award goes to the entire NHL. There was some dispute among the judges on this one, as several never realized the NHL was gone. ...
The Dangers of Antibacterial Soap Jan 1, 2006
Natural Life, At issue are antibacterial products that include chemicals such as triclosan, which is known for its bacteria-fighting properties. ...
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