Indication: For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae, Upper respiratory tract infections caused by Streptococcus pneumoniee; For the treatment of asymptomatic carriers of Neisseria meningitidis
Pharmacology: Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Minocycline is used to treat nongonococcal urethritis, mucopurulent cervicitis, acne vulgaris, and rheumatoid arthritis and some othet infections. Because of its lipid solubility, minocycline is able to eradicate the meningococcal carrier state in tears and saliva.
Mechanism Of Action: Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30 S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Drug Category: Anti-bacterial Agents; Tetracyclines; ATC:A01AB23; ATC:J01AA08
Dosage Forms: Capsules; Subgingival (sustained-release); IV Injection;
Absorption: rapidly absorbed from the gastrointestinal tract
Interactions:
DrugBank: Interactions for Minocycline
Interactions for Minocycline:
Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant
therapy may require downward adjustment of their anticoagulant dosage.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid
giving tetracycline-class drugs in conjunction with penicillin.
Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and iron-containing
preparations.
The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.
Chemical IUPAC Name: 2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione
Chemical Formula: C23H27N3O7
Half Life: 11.1-22.1 hours
Drug Type: Approved Drug
# Accession No: APRD00547
CAS Registry Number: 10118-90-8
Minocycline News (When available)
Personal Products Company Completes Acquisition of REMBRANDT(R) ...Dec 21, 2005 Yahoo! News (press release) ...growing oral health market with a full line of floss, rinse and toothbrush products, marketed under the REACH® brand, as well as ARESTIN® (minocycline HCl) 1 ...
