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Milrinone
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DRUG INFO
Milrinone
Drug Name:
Milrinone
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Indication: Indicated for the treatment of congestive heart failure.
Pharmacology: Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mechanism Of Action: Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Drug Category: Vasodilator Agents; Cardiotonic Agents; ATC:C01CE02
Brand Names/Synonyms: Corotrop; Corotrope; Milrila; Milrinone; Milrinone Lactate; Milrinone Lactose in 5% Dextrose; Primacor
Dosage Forms: LIQUID
Absorption: Milrinone is rapidly and almost completely absorbed after oral administration. Bioavailability is 92% (in healthy volunteers).
Interactions:
DrugBank: Interactions for Milrinone
Interactions for Milrinone:
No untoward clinical manifestations have been observed in limited experience with patients in whom PRIMACOR was
used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin;
isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril;
heparin, warfarin, diazepam, insulin; and potassium supplements.
Chemical Interactions
There is an immediate chemical interaction which is evidenced by the formation of a precipitate when furosemide is
injected into an intravenous line of an infusion of PRIMACOR. Therefore, furosemide should not be administered in
intravenous lines containing PRIMACOR.
Chemical IUPAC Name: 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Chemical Formula: C12H9N3O
Half Life: 2.3 hours
Drug Type: Approved Drug
# Accession No: APRD00010
CAS Registry Number: 78415-72-2
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