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Methysergide
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DRUG INFO
Methysergide
Drug Name:
Methysergide
Indication: For the treatment of vascular headache
Pharmacology: Methysergide has been shown, in vitro and in vivo, to inhibit or block the effects of serotonin, a substance which may be involved in the mechanism of vascular headaches. Serotonin has been variously described as a central neurohumoral agent or chemical mediator, as a "headache substance" acting directly or indirectly to lower pain threshold, as an intrinsic "motor hormone" of the gastrointestinal tract, and as a "hormone" involved in connective tissue reparative processes.
Mechanism Of Action: Methysergide is serotonin antagonists acts on central nervous system (CNS), which directly stimulates the smooth muscle leading to vasoconstriction. Some alpha-adrenergic blocking activity has been reported. Suggestions have been made by investigators as to the mechanism whereby Methysergide produces its clinical effects, but this has not been finally established, although it may be related to the antiserotonin effect. .
Drug Category: Vasoconstrictor Agents; Serotonin Antagonists; Sympatholytics; ATC:N02CA04
Brand Names/Synonyms: Sansert; Deseril; Desernil; Desernyl; Deseryl; Methyllysergic acid butanolamide; Methysergid; Methysergide [USAN:BAN:INN]; Methysergidum [INN-Latin]; Metisergide [DCIT]; Metisergido [INN-Spanish]; N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamide; N-(alpha-(Hydroxymethyl)propyl)-1-methyl-dextro-lysergamide
Dosage Forms: TABLET
Absorption: Rapid
Interactions: Interactions for Methysergide:
Methysergide may reverse the analgesic activity of narcotic analgesics. Concurrent use with vasoconstrictor agents including ergot alkaloids, sumatriptan, and nicotine (e.g. smoking) may result in enhanced vasoconstriction.
Chemical IUPAC Name: Not Available
Chemical Formula: C21H27N3O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00463
CAS Registry Number: 361-37-5
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Methysergide News
(When available)
Christmas tree pickup established at 3 parks Dec 27, 2005
Beaumont Enterprise, Trees stripped of their stands, decorations and any plastics can be left at Rogers Park at Dowlen and Gladys; Sprott Park at Usan and Virginia; and Magnolia ...
Clemson 52, Winthrop 51 Dec 20, 2005
Gainesville Sun, ...usan Yenser's putback in the final second gave Clemson a 52-51 win over Winthrop on Tuesday night. The Lady Tigers (5-6) led 48-37 ...
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