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Methoxyflurane
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DRUG INFO
Methoxyflurane
Drug Name:
Methoxyflurane
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Indication: For use in the induction and maintenance of general anesthesia
Pharmacology: Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism Of Action: Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Category: Anesthetics, inhalation; ATC:N01AB03
Brand Names/Synonyms: Analgizer; Anecotan; CCRIS 5840; CHEMBANK4387; DA-759; HSDB 7201; Ingalan; Inhalan; Kaxppldpdptatadttajj`@; MOF; Methofane; Methoflurane; Methoxane; Methoxiflurane; Methoxifluranum; Methoxyfluoran; Methoxyfluorane; Methoxyfluran; Methoxyflurane; Methoxyflurane [Usan:Ban:Inn]; Methoxyfluranum [Inn-Latin]; Metofane; Metossiflurano [Dcit]; Metoxfluran; Metoxifluran; Metoxiflurano [Inn-Spanish]; NSC-110432; Penthrane; Pentran; Pentrane
Dosage Forms: SPRAY
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 2,2-dichloro-1,1-difluoro-1-methoxy-ethane
Chemical Formula: C3H4Cl2F2O
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00744
CAS Registry Number: 76-38-0
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