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Methdilazine
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DRUG INFO
Methdilazine
Drug Name:
Methdilazine
Indication: Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders
Pharmacology: In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Methdilazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism Of Action: Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Category: Antihistamines; ATC:R06AD04
Brand Names/Synonyms: Bristaline; Dilosyn; Disyncram; Disyncran; MJ 5022; Md; Methdilazine; Methdilazine Hcl; Methdilazine Hydrochloride; Methdilazine Monohydrochloride; Methdilazine [Usan:Ban:Inn]; Methdilazinum [Inn-Latin]; Methilazine Hydrochloride; Methodilazine; Metodilazina [Inn-Spanish]; NCI-C60720; Product 5022; Tacaryl; Tacaryl Hydrochloride; Tacazyl; Tacryl
Dosage Forms: Syrup, Tablets, Chewable tablets
Absorption: Well absorbed in the digestive tract.
Interactions: Not Available
Chemical IUPAC Name: 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
Chemical Formula: C18H20N2S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00713
CAS Registry Number: 1982-37-2
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Methdilazine News
(When available)
(BW) Mirage Networks Expands Full-Cycle Network Access Control ... 16 Jan 2006
Houston Chronicle, AUSTIN, Texas--(BUSINESS WIRE)--Jan. 16, 2006--Product Enhances Complete Enterprise Support; Represents New Revenue Opportunities for Partners. ...
TradeStone Software Automates Product Lifecycle Management for ... 16 Jan 2006
TMCnet TradeStone Software today announced that it has added Product Lifecycle Management (PLM) to its TradeStone Suite. The PLM for Retail ...
Reynolds makes product upgrade 16 Jan 2006
Dayton Business Journal, Now, dealerships can order the Reynolds product -- called Contact Management 3.2 -- even if they use another company's platform. ...
Milk product market likely to continue to grow this year: KRC 16 Jan 2006
Thai News Agency MCOT, BANGKOK, Jan 16 (TNA) – The milk product market is expected to continue to grow this year with the value of around 32 billion baht, up 8% from last year ...
Penguin Computing Recruits HP Executive to Drive Product ... 16 Jan 2006
PR Newswire (press release), ...the leader in dramatically simple Linux clustering, announced today that Pauline Nist joined the company as Senior Vice President of Product Development and ...
ProMetic Product Used in the Manufacture of an FDA-Approved ... 16 Jan 2006
CCNMatthews (press release), An FDA approval of a client's product contributes to ProMetic's recurring revenue by way of ongoing adsorbent supply for product manufacture. ...
Telarix Marks 2005 with Continued High Growth and Product ... 16 Jan 2006
TMCnet VIENNA, Va. --(Business Wire)-- Jan. 16, 2006 -- Telarix, Inc., the leading innovator in Interconnect Business Optimization (IBO ...
Oil product export to Iraq could be suspended 16 Jan 2006
Turkish Daily News (subscription), Turkey's trade minister, Kurþad Tüzmen, warned Iraq that Turkish companies would suspend exports of oil products on Jan. 21 if ...
ipoque Releases Skype(TM) Filter and Extends Product Line 16 Jan 2006
PR Web (press release), ...ipoque releases new VoIP filter module for its line of PRX traffic managers which support detecting and blocking of Voice over IP traffic including SkypeTM. ...
Northside product returns home 16 Jan 2006
The Daily Advertiser, After spending his freshman year of college football as a bystander on the sidelines of the Ole Miss Rebels, defensive back Tyson Andrus has decided to return ...
New Product Converts Motorola iDEN Phones Into Desktop System and ... 16 Jan 2006
LBS-zone.com (press release), New Product Converts Motorola iDEN Phones Into Desktop System and Local Phone Companion Now Available for Sprint Nextel Users. MIAMI ...
SPSS' New Data Mining Product Will Significantly Boost CRM ... 16 Jan 2006
Business Wire (press release), ..."We applaud SPSS' committed effort to take an already outstanding product to the next level," said Daniele Micci-Barreca, PhD, a principal at Elite Analytics. ...
Pact with South Korea’s Kukil will expand WWC product range 16 Jan 2006
Malaysia Star, ...board listed Wonderful Wire & Cable Bhd, sees its just-signed pact with South Korean gaskets maker Kukil Inntot (Korea) Co Ltd as boosting its product range. ...
Dragonwave Expands Airpair Product Portfolio 16 Jan 2006
Ottawa Business Journal, ...operators.". The UpMast Radio Switch (UMRS) complements the industry leading mesh restoration capability of the AirPair product. ...
Cutting miniature/micro-product production costs 16 Jan 2006
Manufacturing Talk, Technologies and systems are being developed for mass production of miniature and micro-products to cut down manufacturing costs by approximately 40 to 80%. ...
Harman Debuts New JBL iPod Product 16 Jan 2006
Designtechnica, By Nino Marchetti. Harman Multimedia, at MacWorld last week in San Francisco, unveiled a new iPod speaker dock and “time machine. ...
Product Development Manager 16 Jan 2006
ElectronicsWeekly.com, University in 1999, the AIM listed company has enjoyed tremendous success since its inception culminating in its first shipment of product in December 2005. ...
Germany : Messe Frankfurt poised to launch campaign against ... 16 Jan 2006
Fibre2fashion.com, ...innovation and performance, has shown a considerable interest in ensuring that prosecutions and sanctions are imposed against brand and product pirates. ...
NORDICMIND: Touchpaper Launches New Product Portfolio for IT ... 16 Jan 2006
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Cancer organizations join efforts to product atlas that maps ... 16 Jan 2006
Newstarget.com, NIH News reports that a collaborative venture between the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) has produced ...
Ears in 150 nations tuned to SA product 16 Jan 2006
Advertiser Adelaide, Managing director Mike Heard said the product, together with its radio unit, made up about 50 per cent of the company's total sales. ...
US: NGC's e-PDM to boost Wilsons' product development 16 Jan 2006
just-style.com, Wilsons The Leather Experts has selected New Generation Computing (NGC’s) product lifecycle management technology e-PDM, Internet Product Development Manager ...
Snow Brand Milk Products Launches New Supplement Product in US 16 Jan 2006
Investor's Business Daily (subscription) Japan, Jan 16, 2006 (JCN Newswire via COMTEX) -- Snow Brand Milk Products has introduced Women's Ultra Mega Bone Density, a supplement product containing milk ...
New Online Poker Product Proving Popular 16 Jan 2006
Online Casino News, ...“This is an extremely encouraging debut for any new product, let alone poker, so we are doubly-excited that we have a massive poker hit on our hands�, said ...
Snow Brand Milk Products Launches New Supplement Product in US 16 Jan 2006
Japan Corporate News (press release), Tokyo (JCN) Jan 16, 2006 - Snow Brand Milk Products has introduced Women's Ultra Mega Bone Density, a supplement product containing milk basic protein (MBP ...
SWEDEN: Twilfit invests in product development software 16 Jan 2006
just-style.com, Swedish ladies’ fashion and lingerie retailer Twilfit AB has invested in a range of collaborative product development tools from Geac. ...
Analog devices sells product line to Ikanos 16 Jan 2006
channel-e, Analog Devices has sold its product segment of the FUSIV network processors and ADSL-ASICs to Ikanos Communications for approximately 30 m US$. ...
Window to the world: Specialty Power Windows sells product beyond ... 16 Jan 2006
Macon Telegraph, By Chuck Thompson. But that didn't keep his Specialty Power Windows from recently being recognized as the Forsyth-Monroe County Chamber ...
Forecast of retail sales by product group for 2006 16 Jan 2006
Moneyweb, Projections compiled by Dr Deon Tustin (Senior researcher) according to retail product group shows that the average real growth in the retail sales of footwear ...
Aspen SUV isn't too late, says Chrysler product exec 16 Jan 2006
Automotive News ...a waning consumer appetite for SUVs, the Chrysler Aspen is not too late to the party, says Frank Klegon, executive vice president of product development for ...
(BW) Cortexa Technology Introduces Premium Quality Touchscreen at ... 16 Jan 2006
Houston Chronicle, ..."Touchscreens are an integral part of the home automation system, and this full featured panel is an important addition to our product line.". ...
Crane awards Spitfire's sales 16 Jan 2006
VNUNet.com, BCM is a converged voice and data product that offers telephony, unified messaging, multimedia call centre, interactive voice response, IP routing and data ...
MatrixOne Allows Organizations to Transform Existing Knowledge ... 16 Jan 2006
Business Wire (press release), WESTFORD, Mass.--(BUSINESS WIRE)--Jan. 16, 2006--MatrixOne, Inc. (NASDAQ: MONE), a leading provider of collaborative product lifecycle management (PLM ...
Micro Technologies Launches ‘Micro VBB Marshal’ - The First ... 16 Jan 2006
The IT Shield (press release), Micro VBB Marshal is a mobile phone and GIS based vehicle location and tracking applications security product with RFID. . Micro ...
Uganda’s Vermiculite export volume doubles 16 Jan 2006
The Monitor, Uganda, In March last year Canmin through its research division, the Uganda Vermiculite Institute developed a new vermiculite-based crop enhancement product that is ...
Experts Warn Of Home Heating Safety Issues 16 Jan 2006
KETV.com, ...as safely as possible. Don't sacrifice safety," Consumer Product Safety Commission spokeswoman Patty Davis said. "I'm all wrapped ...
Innovation is global, says Microsoft executive 16 Jan 2006
ITworld.com, Rashid: We never know when something is going to change into a product. ... Do you see this technology getting into a product from Microsoft? ...
GDP growth slows in 2004 16 Jan 2006
Royal Gazette, In total, the Island’s Gross Domestic Product expanded by 5.1 percent to $4.5 billion, or 1.6 percent in real growth after inflation adjustment, data ...
Media Matchmaker Launches System That Helps Media to Find ... 16 Jan 2006
PR Web (press release), ...delivery platforms and time-shifting devices have combined to severely undermine traditional advertising, while fueling an explosion in product placement and ...
Bringing up baby includes tax plans, college savings accounts 16 Jan 2006
Rocky Mountain News, Look for the Juvenile Products Manufacturers Association seal of approval; read Consumer Reports reviews; read packaging to make sure the product is designed ...
Ensuring safety of consumer goods 16 Jan 2006
News Today, The US Consumer Product Safety Commission (CPSC) has signed a memorandum of understanding with India to improve the safety of consumer products exported to ...
McAfee's policy enforcer 16 Jan 2006
iT News, The product, which has yet to be priced, will check connecting devices to ensure proper security settings and patch levels are in place. ...
Bluetooth Chip Shipments in China is Expected to Reach 866 Million ... 16 Jan 2006
Business Wire (press release), The development of chip is closely related to the development of product application. Bluetooth can be widely applied to the fields ...
TVM Building Products Unveils New Reflective House Wrap 16 Jan 2006
PR Web (press release), This revolutionary new product offers the construction industry a strong weather-resistant barrier with the added benefit of 96% reflectivity, an R-3.8 value ...
Jonah Goldberg: Senate 'show trial' is product of a too-powerful ... Jan 12, 2006
Dallas Morning News (subscription), There's a great scene in The Simpsons set in the not-too-distant future when Marge says to Homer, "You know, Fox turned into a hardcore sex channel so gradually ...
Treasury Services Product Leader Jan 15, 2006
The Spokesman Review, Overseeing cash/treasury management products, you will develop, implement and manage deposit and ancillary products; evaluate product profitability and market ...
Security firm launches state-of-art product, services Jan 15, 2006
Sun.Star, Maximum Security�. The event, presenting new product and service offerings was held on December 17,2005 at the SVD grounds. Probe ...
CFIF, UP launch course on industrial product design to help local ... Jan 15, 2006
Sun.Star, CFIF president Michael Basubas said the industrial design course, a collaboration of the CFIF and UPCC under its product development and design program, was ...
Garmin Announces GPS Product Support for Mac OS X Jan 15, 2006
LBS-zone.com (press release), ...or its subsidiaries. Anticipated product availability dates are based on management's current expectations and are not guaranteed.
Frank Klegon, executive vice president, product development Jan 15, 2006
Rockford Register Star, The Caliber is unlike anything in the small-car market. What did you look at to create the Caliber? What we tried to do with Caliber was invent something new. ...
Performance Technologies' NexusWare(TM) Linux-Based Software Suite ... Jan 14, 2006
LXer, NexusWare was chosen as an INTERNET TELEPHONY Product of the Year due to its strong embodiment of Linux and its ability to facilitate the use of open-source ...
Securing his dream Jan 14, 2006
2theadvocate.com, ...boost about six months ago when international sporting goods retailer and outdoor outfitter Cabela’s decided it wanted to carry a product that Gremillion ...
Koizumi says Japan should boost farm-product exports Jan 14, 2006
Mainichi Daily News, Japan should export more high-quality farm produce instead of selling it at home to protect the domestic market from foreign competition, the prime minister ...
Have Padres truly bettered their product? Jan 13, 2006
San Diego Union Tribune, Their wardrobe being drab, the Padres had to change clothes. Thing is, while some baseball teams shop Rodeo Drive, the Pads buy ...
Drug Companies May Use New Lab Tools to Speed Product Approvals Jan 12, 2006
Bloomberg Jan. 13 (Bloomberg) -- US regulators and the pharmaceutical industry are using new gene-hunting tools and medical imaging machines ...
Does Happiness Matter More Than Wealth? Jan 15, 2006
Medical News Today (press release), While America and many other countries have traditionally measured its success by looking at numbers such as the Gross Domestic Product (previously the Gross ...
LTCquickbid.com to be Used by Healthsouth for Their Transportation ... Jan 15, 2006
PR Web (press release), ...carriers. Transportation needs include padded van services, High Value Product delivery and Office and Industrial relocations. Birmingham ...
Senate 'show trial' is product of a too-powerful court Jan 10, 2006
USA Today By Jonah Goldberg. There's a great scene in The Simpsons set in the not-too-distant future when Marge says to Homer, "You know, Fox ...
Steamy movies? Starbucks will add DVDs to its product line Jan 13, 2006
Salt Lake Tribune, By Mary Jane Credeur. Starbucks Corp., seller of music CDs and co-producer of Ray Charles' triple-platinum ''Genius Loves Company ...
Micro Technologies launches security product for ITeS & BPO Jan 13, 2006
India Infoline.com, Micro Technologies (I) Limited on Friday launched ‘Micro VBB Marshal’- the first-ever customized security product for the ITES & BPO industry which will go ...
Performance Technologies' NexusWare(TM) Linux-Based Software Suite ... Jan 13, 2006
PR Newswire (press release), ...of integrated systems, platforms, components and software, today announced the company's NexusWare(TM) Linux-based software suite was named Product of the Year ...
Product Recall: Pilates Exercise Balls Jan 13, 2006
WebMD The recall was voluntarily conducted on Jan. 10 by LTD Commodities and The Lakeside Collection in cooperation with the Consumer Product Safety Commission. ...
BayPackets Receives INTERNET TELEPHONY(R) Magazine's ''Product of ... Jan 13, 2006
Business Wire (press release), Marketing Corporation (TMC(R))'s INTERNET TELEPHONY(R) magazine (www.itmag.com) has named BayPackets' Agility Multimedia Ringback Tone its 2005 Product of the ...
NCSL: Proposed FDA Rule Preempts State Product Liability Laws ... Jan 13, 2006
U.S. Newswire (press release), 13 /US Newswire/ -- The Food and Drug Administration is attempting a back-door approach to preempt state prescription drug product liability laws despite ...
AppForge Awarded First Patent for Crossfire Product Jan 13, 2006
PR Newswire (press release), Patent Validates Innovation Present Within Company's Mobile Application Services Development Platform Product ATLANTA, Jan. 13 /PRNewswire ...
Echo(TM) by BenchmarkPortal Wins 'Product of the Year' Award Jan 12, 2006
PR Newswire (press release), SANTA MARIA, Calif., Jan. 12 /PRNewswire/ -- Recently Customer Inter@ction Solutions (CIS) magazine named Echo(TM) as a 2005 Product of the Year award winner. ...
InQuira Receives Customer Inter@ction Solutions(R) Magazine's ... Jan 13, 2006
PR Newswire (press release), Inter@ction Solutions(R) magazine (http://www.cismag.com) has named the InQuira 7 Customer Interaction Platform as a recipient of a 2005 Product of the Year ...
Analog Devices sells product line to Ikanos for undisclosed amount Jan 13, 2006
Boston Business Journal, ...announced Friday it has reached an agreement to sell a product line for undisclosed terms to semiconductor networking company Ikanos Communications Inc. ...
Analog Devices deals product lines to Ikanos Jan 13, 2006
Boston Mass High Tech, ...to sell its FUSIV network processor and Asymmetrical Digital Subscriber Line product line. This product line represents about 2 ...
'A quality product' Jan 13, 2006
Midland Daily News (subscription), Minor league baseball players don't make millions of dollars. They don't fly first class. And they aren't household names. That ...
AppForge Awarded First Patent for Crossfire Product Jan 13, 2006
Yahoo! News (press release) The patent applies to the core functionality built into the company's Crossfire Client product that enables platform-independent component architecture ...
AppForge Awarded First Patent for Crossfire Product Jan 14, 2006
ag-IP-news Agency, According to a press release by the company, the Patent applies to the core functionality built into the company’s Crossfire Client product that enables ...
Favrille cancer product receives fast track status Jan 13, 2006
Pharmaceutical Business Review ...the FDA. The B-cell follicular non-Hodgkin's lymphoma (NHL) treatment is Favrille's lead product candidate for this disease. The ...
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