Indication: For use in the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
Pharmacology: Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites.
Mechanism Of Action: Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.
Drug Category: Anticholinergic Agents; Antispasmodics; ATC:A03AB07
Interactions:
DrugBank: Interactions for Methantheline
Interactions for Methantheline:
This drug may interact with the following: antacids, diarrhea medicine
containing kaolin or attapulgite, ketoconazole (using these medicines with an anticholinergic may lessen the effects
of the anticholinergic), central nervous system (CNS) depressants (taking scopolamine with CNS depressants may
increase the effects of either medicine), other anticholinergics (medicine for abdominal or stomach spasms or
cramps), tricyclic antidepressants (taking anticholinergics with tricyclic antidepressants or other anticholinergics
may cause an increase in the effects of the anticholinergic), and potassium chloride (using this medicine with an
anticholinergic may make gastrointestinal problems caused by potassium worse).
Chemical IUPAC Name: diethyl-methyl-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]ammonium
Chemical Formula: C21H26NO3
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00751
CAS Registry Number: 5818-17-7
Methantheline News (When available)
How to control excessive sweatingDec 26, 2005 Naples Daily News (subscription), ...system. Pro-Banthine (probantheline bromide), taken daily for as long as the sweating persists, is one of these medications. Possible ...
Aphton Announces Receipt of NASDAQ Notice of Non-Compliance ...Jan 3, 2006 Genetic Engineering News, Aphton has strategic alliances with Xoma for treating gastrointestinal and other gastrin-sensitive cancers using anti-gastrin monoclonal and other antibodies ...
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