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Mequitazine
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DRUG INFO
Mequitazine
Drug Name:
Mequitazine
Indication: For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Pharmacology: In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Mequitazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism Of Action: Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Category: Bronchodilator Agents; Histamine H1 Antagonists; ATC:R06AD07
Brand Names/Synonyms: Butix; CHEMBANK2839; Instotal; Kitazemin; LM 209; LM-209; Mequitazina; Mequitazina [Inn-Spanish]; Mequitazina [Spanish]; Mequitazine; Mequitazine [Ban:Dcf:Inn:Jan]; Mequitazinum [Inn-Latin]; Metaplexan; Mircol; Primalan; Vigigan; Virginan; Zesulan
Dosage Forms: Tablet
Absorption: Not Available
Interactions: Drug Interactions:
Mequitazine can interact with CNS depressant, antichlolinergic, TCA, MAOIs, and alcohol.
Chemical IUPAC Name: 10-(4-azabicyclo[2.2.2]oct-7-ylmethyl)phenothiazine
Chemical Formula: C20H22N2S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00386
CAS Registry Number: 29216-28-2
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Mequitazine News
(When available)
Vick Dismissed By Hokies Jan 6, 2006
WCAV, Virginia Tech quarterback Marcus Vick told The Virginan-Pilot that he would enter the NFL Draft on Friday, hours after he was dismissed from the team as a ...
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