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Mephenytoin
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DRUG INFO
Mephenytoin
Drug Name:
Mephenytoin
Indication: For the treatment of refractory partial epilepsy
Pharmacology: Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, Mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.
Mechanism Of Action: The mechanism of action of Mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Drug Category: Anticonvulsants; ATC:N03AB04
Brand Names/Synonyms: Dilantin; Dilantin-125; Epiazin; Epilan; Fenantoin; Gerot-Epilan; Insulton; Mephentoin; Mephenytoin; Mesantoin; Mesdontoin; Mesontoin; Methoin; Methyl Hydantoin; Methylphenetoin; Metydan; NSC-34652; Phenantoin; Phentytoin; Phenylethylmethylhydantoin; Phenytoin; Sacerno; Sedantional; Sedantoin; Sedantoinal; Triantoin
Dosage Forms: Tablet
Absorption: Not Available
Interactions: Drug Interactions:
Some anticonvulsants may interact with Mephenytoin. They can either increase or
decrease the effect of Mephenytoin. Those anticonvulsants include divalproex sodium, valproic acid, and
phenobarbital.
Mephenytoin may also affect the effects of other drugs, which include some steroid medications,
warfarin, certain heart medicines, birth control pills, anti-infective medicines, furosemide and theophylline
Please note that Mephenytoin may interact with other drugs that are not listed here.
Chemical IUPAC Name: 5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione
Chemical Formula: C12H14N2O2
Half Life: ~7 hours
Drug Type: Approved Drug
# Accession No: APRD00512
CAS Registry Number: 50-12-4
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Mephenytoin News
(When available)
Tour mouth can tell dentists a lot about overall health Jan 8, 2006
Annapolis Capital, Dr. Sheen notes gum tissues swell in patients who take Dilantin to reduce seizures. "It is difficult to reduce the swelling," he says. ...
Natural brain boosters & study aids Jan 10, 2006
Open PR (press release), An important study into the effects of the epilepsy drug Dilantin (phenytoin) on vitamin B1 (thiamine) status found that thiamin supplementation (50 to 100mg ...
Sison: Bill expands grounds for legal separation Jan 3, 2006
Sun.Star, 20mg tab (Nifedipine); the liprotropic Lopid 3200mg cap; the sympathomimetic drug Ventolin 100mcg/200do (Salbutamol); and the hydantoin Dilantin 100mg cap ...
ASPARTAME FEEDBACK DIALOGUE Dec 30, 2005
Free Market News Network, ...dorway.com? The victim goes to the ER and probably will be given something like Dilantin, an anti-seizure medication. Because the ...
DYING TO LOOK GOOD: The Disturbing Truth About What’s Really in ... Jan 11, 2006
PR Web (press release), These chemicals will form nitrosamines in the presence of ingredients like sodium hydroxymethylglycinate, quaternium-15, DMDM hydantoin and diazonlidnyl urea. ...
Sison: Bill expands grounds for legal separation Jan 3, 2006
Sun.Star, Retard 20mg tab (Nifedipine); the liprotropic Lopid 3200mg cap; the sympathomimetic drug Ventolin 100mcg/200do (Salbutamol); and the hydantoin Dilantin 100mg ...
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