Indication: Used to control moderate to severe pain.
Pharmacology: Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class. Meperidine may produce less smooth muscle spasm, constipation, and depression of the cough reflex than equivalent doses of morphine. The onset of action is lightly more rapid than with morphine, and the duration of action is slightly shorter. The chemical structure of Meperidine is similar to local anesthetics. Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. Meperidine is considered a second-line agent for the treatment of acute pain.
Mechanism Of Action: Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Meperidine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Category: Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N02AB
Absorption: Oral bioavailability is 50-60% in patients with normal hepatic function.
Interactions:
DrugBank: Interactions for Meperidine
Interactions for Meperidine:
Interaction with Other Central Nervous System Depressants: MEPERIDINE SHOULD BE USED WITH GREAT CAUTION AND
IN REDUCED DOSAGE IN PATIENTS WHO ARE CONCURRENTLY RECEIVING OTHER NARCOTIC ANALGESICS, GENERAL ANESTHETICS,
PHENOTHIAZINES, OTHER TRANQUILIZERS, SEDATIVE-HYPNOTICS (INCLUDING BARBITURATES), TRICYCLIC ANTIDEPRESSANTS AND OTHER
CNS DEPRESSANTS (INCLUDING ALCOHOL). RESPIRATORY DEPRESSION, HYPOTENSION, AND PROFOUND SEDATION OR COMA MAY
RESULT.
Chemical IUPAC Name: ethyl1-methyl-4-phenyl-piperidine-4-carboxylate
Chemical Formula: C15H21NO2
Half Life: 3-5 hours
Drug Type: Approved Drug
# Accession No: APRD00074
CAS Registry Number: 57-42-1
Meperidine News (When available)
Remodeling – A Cautionary TaleJan 10, 2006 New West, I pull my wool hat down to my eyebrows, trying to hold the last vestiges of the Demerol and that drug-that-makes-you-forget in my noggin. ...
Drugs for sedation during colonoscopies to undergo studyDec 23, 2005 Kansas City Nursing News, ...and Associates to conduct a study on patient responses, patient satisfaction and consistency of pain management in the use of meperidine/Demerol versus Fentanyl ...
Ask the Clinician: Answers to Readers' QuestionsJan 9, 2006 About - News & Issues, She has at her disposal 180 Percocet pills a month, Demerol shots to use as needed, two anti-seizure medications (for she also has seizures), one of those ...
Trial Begins in 2003 Shooting of Lawyer Outside CourthouseDec 28, 2005 Los Angeles Times, His attorney said he was under the influence of Demerol at the time of the shooting and was suffering from a "blackout" and a "psychotic break" when he ...
The good stories of this yearDec 31, 2005 Bothell Herald, ...blood pressure dropped to 70 over 40. He was given Demerol for the steadily intensifying pain. Unable to come to a firm diagnosis ...
Health professionals disciplinedJan 1, 2006 Springfield State Journal Register, Her licensed practical nurse license was indefinitely suspended for taking Demerol from her employer, Jacksonville Convalescent Center in Jacksonville. ...
Doctor faces suspensionJan 7, 2006 Beloit Daily News, ...and October 2004. Drugs prescribed included strong painkillers such as Demerol, methadone, morphine and oxycotin. The summary suspension ...
Michael Jackson Slams Drug AllegationsDec 12, 2005 Launch Yahoo ...hiring good attorneys.". In their story, the National Enquirer claimed that Jackson had overdosed on Demerol and alcohol. Jackson has ...
Victim of 'modern Burke and Hare'Dec 22, 2005 Scotsman, ...malpractice lawsuits filed against him, passed out while working on patients because of the extent to which he was under the influence of the painkiller Demerol ...
BBC star's bones soldDec 23, 2005 Advertiser Adelaide, He started the company after losing his dental licence because of an addiction to Demerol that allegedly saw him fall asleep during an operation. ...
by Christopher LargenDec 15, 2005 Village Voice, ...one week. Throughout his life, he has been prescribed morphine, Demerol, Codeine, Valium, and other sedating medications. He has ...
Chesapeake doctor enters Alford plea in narcotics caseDec 23, 2005 Virginian Pilot, ...wife, Carol D. Loxley, who had worked at his practice, also pleaded guilty to a single drug-related charge, alleging she obtained Demerol fraudulently, court ...
Paramedic arrested on drug-related chargesDec 12, 2005 Winston-Salem Journal, ...vials. They say that he also took small amounts of the painkiller Demerol and Ativan, a drug used to relieve symptoms of anxiety. ...
Doc faces new claims he gave painkillers to wifeJan 6, 2006 Glasgow Evening Times, Lawrence, an ex-consultant at Glasgow's Victoria Infirmary, was disciplined in 2003 after admitting prescribing his wife Anne pethidine for migraines. ...
India sends over $15mln relief supplies for quake-victims in ...Jan 7, 2006 GreaterKashmir.com (press release), Blankets 25500, Tents 2200, Sleeping Bags 15200, Plastic/FRP Sheets 41500, Medicines 30 tonnes, Anti-Tetanus Injections 10000, Pethidine Injection 10000 and ...
India has sent relief material to Pak worth Rs 69 crore so farJan 6, 2006 Webindia123, 25,500), Tents (2,200), Sleeping Bags (15,200), Plastic/FRP Sheets (41,500), Medicines (30 tonnes), Anti-Tetanus Injections (10000), Pethidine Injection (10,000 ...
Euthanasia's Growing AcceptanceJan 8, 2006 Zenit News Agency, In March 2003 she gave her mother an injection of insulin, and about eight months later injected her father with insulin and pethidine and put a plastic bag ...
Legal case reopens euthanasia debateDec 20, 2005 ABC Online, ...father's suicide. This included injecting morphine and pethidine into her father, and tying a plastic bag over his head. Despite ...
What a doula doesDec 18, 2005 The Herald, Pain: say what kinds of pain relief you want to use, if any, and in what order (for example, you might prefer to try pethidine before an epidural). ...
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