Indication: For the treatment of insomnia and jet lag
Pharmacology: Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag.
Mechanism Of Action: Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.
Drug Category: Free Radical Scavengers; Antioxidants; Anticonvulsants; Adjuvants, Immunologic; ATC:N05CM17
Absorption: The absorption and bioavailability of melatonin varies widely.
Interactions:
DrugBank: Interactions for Melatonin
Interactions for Melatonin:
Melatonin may interact with the following drugs: aspirin and other NSAIDs (may
lower melatonin levels), fluvoxamine (bioavailability of oral melatonin is increased with coadministration), beta
blockers (may decrease melatonin levels), fluoxetine (reports of psychotic episodes when coadministered), progestin
(coadministration of melatonin with progestin can inhibit ovarian function in women), benzodiazepenes and other
sedating drugs (may result in additive sedation and an increased incidence of adverse effects), and corticosteroids
(coadministration of melatonin and corticosteroids may interfere with the efficacy of the corticosteroids).
Chemical IUPAC Name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ethanamide
Sleep pillow feels just right for good night's restJan 12, 2006 Scripps Howard News Service, By CATHIE FILIAN and STEVE PIACENZA. With just three natural ingredients and a little stitch of know-how, you can craft your way to a great nights sleep. ...
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Help child do best on testsJan 12, 2006 Honolulu Advertiser, Prepare for the test. Make sure your child has a good night's rest before the test and eats a hearty breakfast the morning of the test. ...
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Boy, 16, smiling at end of his Iraq escapadeJan 2, 2006 Miami Herald, ...``I hope to get a good night's rest.''. Even before Farris landed, there was talk of who would land his first post-war-zone interview. ...
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New inn ushers in a brand new yearJan 1, 2006 Burlington Hawk Eye, ...located at one spot — and it's very safe.". The final bonus is a free breakfast offered after a good night's rest in a guest suite.
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A visit with Father FrostDec 22, 2005 Juneau Empire, After a good night's rest, we arrived at 10 am and were met by my friend, Vladimir Latyntsev, a talented oil painter from Vologda. ...
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