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Mecamylamine
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DRUG INFO
Mecamylamine
Drug Name:
Mecamylamine
Indication: For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Pharmacology: Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers.
Mechanism Of Action: Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
Drug Category: Antihypertensive Agents; Nicotinic Receptor Antagonist ATC:C02BB01
Brand Names/Synonyms: Versamine; Inversine; Revertina; Inversine hydrochloride; Mecamilamina; Mecamine; Mecamine hydrochloride; Mecamylamine Hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 2-Norbornanamine, N,2,3,3-tetramethyl-; 2-Norbornanamine, N,2,3,3-tetramethyl-, hydrochloride; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride
Dosage Forms: Tablets
Absorption: Mecamylamine is almost completely absorbed from the gastrointestinal tract
Interactions: Interactions for Mecamylamine:
Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers.
The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.
Chemical IUPAC Name: N,2,3,3-tetramethylnorbornan-2-amine
Chemical Formula: C11H21N
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00458
CAS Registry Number: 60-40-2
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Mecamylamine News
(When available)
Targacept and AstraZeneca Announce Global License and Research ... Dec 31, 2005
Drug Newswire (press release), Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ...
Targacept, AstraZeneca Enter TC-1734 Deal For Up To $300M Dec 28, 2005
BioWorld Online (subscription), Targacept has one marketed product, Inversine (mecamylamine hydrochloride), which was acquired from Sunnyvale, Calif.-based Layton Bioscience Inc. ...
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