Indication: For the management of the manifestations of psychotic disorders
Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Mechanism Of Action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
Drug Category: Antipsychotics; Antipsychotics; Dopamine Antagonists; ATC:N05AH01
Dosage Forms: Tablet; Capsule; Oral Solution; IV Solution; IM Solution
Absorption: Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Interactions:
DrugBank: Interactions for Loxapine
Interactions for Loxapine:
There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant
use of loxapine and lorazepam.
The risk of using loxapine in combination with CNS-active drugs has not been systematically evaluated. Therefore,
caution is advised if the concomitant administration of loxapine and CNS-active drugs is required.
