|
Loratadine
resources
|
|
|
|
|
|
DRUG INFO
Loratadine
Drug Name:
Loratadine
Indication: For the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older
Pharmacology: Loratadine, a non-sedating H1-blocker similar in structure to cyproheptadine and azatadine, is used to treat seasonal allergic rhinitis. Unlike other H1-blockers, loratidine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.
Mechanism Of Action: Like other H1-blockers, loratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Loratadine also has a weak affinity for acetylcholine and alpha-adrenergic receptors.
Drug Category: Anti-allergic Agents; Antipruritics; Antihistamines; Histamine H1 Antagonists, Non-Sedating; ATC:R06AX13; ATC:R06AX27
Brand Names/Synonyms: Aerotina; Alarin; Alavert; Alerpriv; Allertidin; Bedix Loratadina; Biloina; Bonalerg; CHEMBANK1389; Civeran; Claratyne; Claratyne Cold; Claratyne Decongestant; Clarinase; Clarinase Reperabs; Clarinex; Claritin; Claritin Reditab; Claritin Reditabs; Claritin-D; Claritine; Clarityn; Clarityne; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina [Spanish]; Loratadine; Loratadine [Usan:Ban:Inn]; Loratadinum [Latin]; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Sanelor; Sensibit; Sinhistan Dy; Sohotin; Tadine; Talorat Dy; Velodan; Versal; Zeos
Dosage Forms: Tablet; Syrup
Absorption: Loratadine was rapidly absorbed following oral administration (40% bioavailability)
Interactions:
DrugBank: Interactions for Loratadine
Interactions for Loratadine:
Loratadine (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and
ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma
concentrations (AUC 0-24 hrs) of loratadine and/or descarboethoxyloratadine were observed following coadministration
of loratadine with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant
changes in the safety profile of loratadine, as assessed by electrocardiographic parameters, clinical laboratory
tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports
of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma
concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that
observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are
summarized in TABLE 1.
| TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Loratadine and
Descarboethoxyloratadine After 10 Days of Coadministration (Loratadine 10 mg) in Normal Volunteers |
| |
Loratadine |
Descarboethoxyloratadine |
| Erythromycin (500 mg q8h) |
+ 40% |
+46% |
| Cimetidine (300 mg qid) |
+103% |
+ 6% |
| Ketoconazole (200 mg q12h) |
+307% |
+73% |
There does not appear to be an increase in adverse events in subjects who received oral contraceptives and
loratadine.
Chemical IUPAC Name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Chemical Formula: C22H23ClN2O2
Half Life: 8.4 hours
Drug Type: Approved Drug
# Accession No: APRD00384
CAS Registry Number: 79794-75-5
|
|
|
|
|
|
Loratadine News
(When available)
Lake Region news Dec 30, 2005
Bradford County Telegraph, ...are unopened over-the-counter medications such as cough syrups, ibuprofen, benedryl, Nyquil, Dayquil,arthritis patches and rubs, milk of magnesia and alavert. ...
[an error occurred while processing this directive]
Northwest briefs Dec 16, 2005
The Olympian, ...about a box of Target Corp. brand cold and al-lergy medicine she bought at Northgate Mall in Seattle. The woman, a registered nurse ...
|
|
|
