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Levofloxacin
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DRUG INFO
Levofloxacin
Drug Name:
Levofloxacin
Indication: For the treatment of Bacterial infection of; Respiratory tract, Urinary tract, GI, CNS and Immuno compromised patients caused by: S.pneumoniae, H.influenzae, M.catarrhalis, S.aureus, H.parainfluenzae, P.aeruginosa, S.marcescens, E.coli, K.pneumoniae, C.pn
Pharmacology: Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.
Mechanism Of Action: Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
Drug Category: Anti-bacterial Agents; Anti-Infectives; Quinolones; ATC:J01MA12; ATC:S01AX19
Brand Names/Synonyms: Cravit; Cravit Ophthalmic; Elequine; Floxel; IQUIX; Leroxacin; Lesacin; Levaquin Leva-Pak; Levaquin; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Quixin; Reskuin; Tavanic; Volequin
Dosage Forms: TABLET, LIQUID, SOLUTION
Absorption: Absorption of ofloxacin after single or multiple doses of 200to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose.
Interactions: Interactions for Levofloxacin:
Specific drug interaction studies have not been conducted with Levofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.
Chemical IUPAC Name: (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate
Chemical Formula: C36H42F2N6O9
Half Life: 6-8 hours .
Drug Type: Approved Drug
# Accession No: APRD00477
CAS Registry Number: 100986-85-4
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Levofloxacin News
(When available)
KAI Pharmaceuticals, Inc. and Sankyo Company, Limited Enter Global ... Jan 9, 2006
Yahoo! News (press release) ...products on the Japanese market, including the antihypertensive Benicar® (olmesartan medoxomil) and the synthetic antibacterial agent Cravit® (levofloxacin). ...
Daiichi Wins Lawsuit Against Mylan Pharmaceuticals Regarding ... Dec 27, 2005
Japan Corporate News (press release), ...until Daiichi's patent expires. Currently, levofloxacin is marketed under the trade names of Cravit in Japan and Levaquin in the US.
Reasons for `insufficient cell count' Jan 2, 2006
Charlotte Observer, ...humans. Campylobacter infection is usually treatable with fluoroquinolones, a family of antibiotics that includes Cipro and Levaquin. ...
Rex Carr seeking $10 million in med-mal trial Jan 11, 2006
Madison County Record, When Dr. Kanumuri received the results of the urine test, he prescribed a medication called Levaquin to treat the urinary tract infection. ...
DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ... Jan 11, 2006
PR Newswire (press release), Lipitor - Norvasc - Cialis - Zocor - Levitra - Pravachol Mood Women's Health Antibiotic Allergy Migraine - Zyprexa - Fosamax - Levaquin - Zyrtec - Imitrex Oral ...
Switching Fluoroquinolones in Patients with Neutropenia May ... Dec 19, 2005
DG News ...found that moxifloxacin (Avelox) could contribute to an increased rate of Clostridium difficile colitis when compared to levofloxacin (Levaquin) in patients ...
FPL to buy Constellation Dec 19, 2005
Pittsburgh Tribune-Review, ...from selling a generic version of the antibiotic Levaquin until December 2010. ... Ortho- McNeil sells Levaquin in the US under a license from Daiichi. ...
Oddo Lifts Sanofi-Aventis Target Price Jan 3, 2006
New Ratings ...the company should win its US Plavix patent trial following the successes of Johnson & Johnson (JNJ) and Pfizer (PFE) in keeping the Levaquin and Lipitor ...
Northern Monmouth Police Blotter Dec 28, 2005
Asbury Park Press, 12 with unlawful possession of Levaquin, an antibiotic, Lasix, a water pill, and dextrometrophan, a cough suppressant by Patrol Officer Tiffanie Dill. ...
Daiichi Wins Lawsuit Against Mylan Pharmaceuticals Regarding ... Dec 27, 2005
Japan Corporate News (press release), ...until Daiichi's patent expires. Currently, levofloxacin is marketed under the trade names of Cravit in Japan and Levaquin in the US.
Tough organism plagues epidemiologists Dec 14, 2005
Florence Morning News, ...than the previous strains.�. Additionally, he said, it appears to now be resistant to strong drugs such as Levaquin. The good news ...
Grammy Nominees Rascal Flatts To Launch 2006 Tour In February Jan 9, 2006
Top40-Charts.com, ...dates through March. 'We could not be more happy to get back out on the road to see our fans,' says lead singer Gary LeVox. 'We aim ...
Rascal Flatts Me & My Gang Tour Jan 9, 2006
Net Music Countdown ...dates through March. "We could not be more happy to get back out on the road to see our fans," says lead singer Gary LeVox. "We aim ...
Rascal Flatts & The Gang Jan 9, 2006
Pollstar ...the tour. "We could not be more happy to get back out on the road to see our fans," Rascal Flatts lead singer Gary LeVox said. "We ...
Grammy's best song nominees come from many genres Jan 7, 2006
Reuters ...tune -- written by Bobby Boyd, Jeff Hanna and Marcus Hummon -- is the group's favorite ballad on "Feels Like Today," with band member Gary LeVox proclaiming it ...
Grammy‘s best song nominees come from many genres Jan 7, 2006
Herald News Daily, ...written by Bobby Boyd, Jeff Hanna and Marcus Hummon -- is the group‘s favorite ballad on "Feels Like Today," with band member Gary LeVox proclaiming it a ...
'Skin' cuts to the bone Dec 24, 2005
Aspen Times, Band member Gary LeVox said the band was deeply affected by the song in part because some of them had lost relatives to cancer, "So we're really in touch with ...
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