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Lepirudin
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DRUG INFO
Lepirudin
Drug Name:
Lepirudin
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Indication: For treatment of heparin-induced thrombocytopenia
Pharmacology: Used to break up clots and to reduce thrombocytopenia. Hirudin binds to thrombin and prevents thrombus or clot formation. Hirudin is a highly potent, selective, and essentially irreversible inhibitor of thrombin and clot-bond thrombin. Hirudin requires no cofactor for its anticoagulant action.
Mechanism Of Action: Hirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade.
Drug Category: Anticoagulants; Antithrombotic Agents; unclassified therapeutic agents (92:00.00)
Brand Names/Synonyms: Hirudin variant-1;Lepirudin; Refludan (Berlex Labs)
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Hirudo medicinalis hirudin (variant 1)
Chemical Formula: C288H448N80O110S6
Half Life: ~1.3 hours
Drug Type: Approved Drug
# Accession No: BIOD00024
CAS Registry Number: 120993-53-5
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