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Lamivudine
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DRUG INFO
Lamivudine
Drug Name:
Lamivudine
Indication: For the treatment of HIV infection and chronic hepatitis B (HBV)
Pharmacology: Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
Mechanism Of Action: Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Drug Category: Anti-HIV Agents; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF05
Brand Names/Synonyms: 3TC; Combivir; DRG-0126; Epivir; Epivir-Hbv; GR 109714X; HSDB 7155; Hepitec; Heptovir; LAMIVUDINE; Lamivudine; Lamivudine [Usan:Ban:Inn]; Trizivir; Zeffix
Dosage Forms: SOLUTION; TABLET
Absorption: Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.
Interactions:
DrugBank: Interactions for Lamivudine
Interactions for Lamivudine:
Lamivudine is predominantly eliminated in the urine by active organic cationic secretion. The possibility of
interactions with other drugs administered concurrently should be considered, particularly when their main route of
elimination is active renal secretion via the organic cationic transport system (e.g., trimethoprim).
TMP 160 mg/SMX 800 mg once daily has been shown to increase lamivudine exposure (AUC) by 44%. No change in dose of
either drug is recommended. There is no information regarding the effect on lamivudine pharmacokinetics of higher
doses of TMP/SMX such as those used to treat Pneumocystis carinii pneumonia. No data are available regarding
interactions with other drugs that have renal clearance mechanisms similar to that of lamivudine.
Lamivudine and zalcitabine may inhibit the intracellular phosphorylation of one another. Therefore, use of
lamivudine in combination with zalcitabine is not recommended.
Chemical IUPAC Name: 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1H-pyrimidin-2-one
Chemical Formula: C8H11N3O3S
Half Life: 5 to 7 hours
Drug Type: Approved Drug
# Accession No: APRD00681
CAS Registry Number: 134678-17-4
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Lamivudine News
(When available)
ICAAC: Switching from Combivir to Truvada has benefits for ... Jan 11, 2006
Aidsmap, Switching fromTruvada (tenofovir and FTC) to Combivir (AZT and 3TC) increases the chances of a patient achieving a viral load below 50 copies/ml, according to ...
Gilead's Truvada Seen Driving Switchers From Combivir Dec 19, 2005
Forbes ...people ) after data from the COMET (Combination of Efavirenz and Truvada) trial presented a compelling argument for switching to Truvada from Combivir for HIV. ...
AIDS prevention treatment uneven Jan 12, 2006
Toronto Star, The treatment regimen — using commonly prescribed combinations of anti-AIDS drugs known as Combivir and Kaletra — costs about $1,200 for a round of therapy ...
AHF Asks Medi-Cal to Place Restrictions on Glaxo AIDS Drug ... Jan 5, 2006
PR Newswire (press release), Trials Group Study (ACTG 5095) comparing AZT+3TC+abacavir (the components of Trizivir) to other regimens (Trizivir + Sustiva and Combivir + Sustiva) when early ...
Bristol-Myers Squibb and Gilead Announce Data Supporting ... Jan 9, 2006
Finanzen.net, Truvada should not be used with Emtriva or Viread, or other drugscontaining lamivudine, including Combivir(R), Epivir(R),Epivir-HBV(R), Epzicom(TM) or Trizivir ...
Companies Anticipate Filing New Drug Application in Second Quarter ... Jan 9, 2006
Nieuwsbank (persbericht), Truvada should not be used with Emtriva or Viread, or other drugs containing lamivudine, including Combivir®, Epivir®, Epivir-HBV®, Epzicom or Trizivir®. ...
ICAAC: Early trials involving new GSK protease inhibitor have ... Dec 19, 2005
Aidsmap, ...against both resistant and sensitive virus, and is generally well tolerated when boosted by ritonavir and used in combination with Combivir, according to a 24 ...
Government drags its feet on patents for AIDS drugs Dec 26, 2005
Newindpress, The ARVs whose patents are awaiting include Abacavir, Combivir, Trizivir, Kaletra, Lexiva and Efavirenz. Combivir is a triple cocktail ...
Combination HIV Drug Trizivir, Along with Tenofovir, Well ... Dec 22, 2005
DG News ...therapy regimen may be able to manage their disease with a once-daily regimen that includes one tablet combining three antiretrovirals (Trizivir) and one ...
AHF Asks Medi-Cal to Place Restrictions on Glaxo AIDS Drug ... Jan 5, 2006
PR Newswire (press release), After Recent NIH Study Proves Trizivir's Ineffectiveness, Nation's Largest AIDS Group Sends Letter to Medi-Cal Requesting Prior Authorization Status for Drug ...
AHF Asks Medi-Cal to Place Restrictions on Glaxo AIDS Drug ... Jan 5, 2006
Yahoo! News (press release) 5 /PRNewswire/ -- Following the results of a recent government study that questioned the efficacy of GlaxoSmithKline's (GSK) AIDS drug, Trizivir, a three drug ...
Co-Administration of Combination Tablet and Tenofovir Elucidates ... Dec 22, 2005
DG News WASHINGTON, DC -- December 22, 2005 -- When HIV develops resistance to the combination antiretroviral drug Trizivir (zidovudine + lamivudine + abacavir) and ...
Bristol-Myers Squibb and Gilead Announce Data Supporting ... Jan 9, 2006
Finanzen.net, ...should not be used with Emtriva or Viread, or other drugscontaining lamivudine, including Combivir(R), Epivir(R),Epivir-HBV(R), Epzicom(TM) or Trizivir(R). Two ...
Companies Anticipate Filing New Drug Application in Second Quarter ... Jan 9, 2006
Nieuwsbank (persbericht), Truvada should not be used with Emtriva or Viread, or other drugs containing lamivudine, including Combivir®, Epivir®, Epivir-HBV®, Epzicom or Trizivir®. ...
(PRN) - Philadelphia Tribune Releases Annual List of ... Jan 5, 2006
Bolsamania.com, Affairs and Quality ... [+. PRN) - AHF Asks Medi-Cal to Place Restrictions on Glaxo AIDS Drug Trizivir ... [+. PRN) - Nuvelo to ...
(PRN) - R&G Financial Announces Certain Actions Taken in ... Jan 5, 2006
Bolsamania.com, President, Regulatory Affairs and Quality ... [+. PRN) - AHF Asks Medi-Cal to Place Restrictions on Glaxo AIDS Drug Trizivir ... [+.
Government drags its feet on patents for AIDS drugs Dec 26, 2005
Newindpress, ...any objections. The ARVs whose patents are awaiting include Abacavir, Combivir, Trizivir, Kaletra, Lexiva and Efavirenz. Combivir ...
First filing for Novartis' hep B drug Jan 4, 2006
Pharma Times (subscription), ...as a big seller after clinical data suggested it was more effective in tackling chronic hepatitis B than GlaxoSmithKline's Zeffix (lamivudine), currently a ...
Idenix/Novartis: filing for hepatitis hope Jan 4, 2006
Pharmaceutical Business Review DNA and ALT levels after 18 months, while at the same time demonstrating lower viral breakthrough, compared to lamivudine (marketed by GlaxoSmithKline as Zeffix ...
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