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Ketamine
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DRUG INFO
Ketamine
Drug Name:
Ketamine
Indication: For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation
Pharmacology: Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems).
Mechanism Of Action: Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, Ketamine does not interact with GABA receptors.
Drug Category: Anesthetics; Analgesics; General Anesthetics; ATC:N01AX03; ATC:N01AX14
Brand Names/Synonyms: CI 581 base; CLSTA 20; Esketamine; Ketaject; Ketalar; Ketalar base; Ketamine; Ketamine Base; Ketamine HCL; Ketanest; Ketolar; l-Ketamine; (-)-Ketamine; (S)-(-)-Ketamine; (S)-Ketamine
Dosage Forms: SOLUTION
Absorption: Rapidly absorbed following parenteral administration
Interactions: Interactions for Ketamine:
Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine.
Ketamine is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.
Chemical IUPAC Name: 2-(2-chlorophenyl)-2-methylamino-cyclohexan-1-one
Chemical Formula: C13H16ClNO
Half Life: ~2.5 3 hours.
Drug Type: Approved Drug
# Accession No: APRD00493
CAS Registry Number: 6740-88-1
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Ketamine News
(When available)
Special K party drug reclassified Dec 31, 2005
DeHavilland, ...health risk. The drug was used in US field hospitals during the Vietnam war and was sold under the brand name Ketalar. Heavy doses ...
Horse tranquilliser used by clubbers is added to banned list Dec 28, 2005
Scotsman, ...as a veterinary tranquilliser it was used in US field hospitals in the Vietnam War and is still used medically for humans under the brand name Ketalar. ...
Horse tranquilliser 'club drug' to be banned Dec 28, 2005
Telegraph.co.uk, ...as a veterinary tranquilliser it was used in American field hospitals in the Vietnam war and is still used medically for humans under the brand name Ketalar. ...
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