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Isosorbide Dinitrate
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DRUG INFO
Isosorbide Dinitrate
Drug Name:
Isosorbide Dinitrate
Indication: For the prevention of angina pectoris due to coronary artery disease
Pharmacology: Isosorbide Dinitrate is a moderate- to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.
Mechanism Of Action: Similar to other nitrites and organic nitrates, Isosorbide Dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Drug Category: Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA08; ATC:D03AX08
Brand Names/Synonyms: Dilatrate; Isochron; Isordil; Titradose; Sorbitrate; Dinitrosorbide; Corosorbide; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Difutrat; Coronex; Flindix; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 87-33-2; AIDS-125686; AIDS125686; Cardio 10; Cardis; Carvanil; Carvasin; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-SR; Dinitrosorbide; Emoper; Flindix; Glucitol, 1,4:3, 6-dianhydro-, dinitrate, D-; Harrical; IBD 20; ISD; ISDN; Ismotic; Iso-Bid; Isoket; Isorbid;; Isordil Tembids; Isosorbide Dinitrate; Isosorbide dinitrate(USAN); Isostat; Isotrate; Korodil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rifloc Retard; Rigedal; Sorbangil; Sorbide T.D.; Sorbide nitrate; Sorbide, dinitrate; Sorbidilat; Sorbidnitrate; Sorbislo; Sorbonit; Sorquad; Tinidil; Vascardin; Vasodilat; Vasorbate; Xanyl
Dosage Forms: Oral tablet
Absorption: Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver.The average bioavailability of isosorbide dinitrate is about 25%
Interactions: DRUG INTERACTIONS
The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators.
Alcohol, in particular, has been found to exhibit additive effects of this variety.
Chemical IUPAC Name: 4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane
Chemical Formula: C6H8N2O8
Half Life: 1 hour
Drug Type: Approved Drug
# Accession No: APRD00455
CAS Registry Number: 87-33-2
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Isosorbide Dinitrate News
(When available)
Pediatric study finds formula for increasing the survival of young ... Jan 3, 2006
Newstarget.com, Although adolescent sports-related deaths are rare, they are commonly caused by cardiovascular problems, such as commotio cardis-cardiac arrest caused by being ...
Holiday giving: What you can do Dec 18, 2005
Providence Journal (subscription), Items may be dropped off at any of the three locations during showroom hours through Friday. Visit cardis.com for more information. ...
Rock groups play for charity Jan 11, 2006
News24, Leningrad Cowboys, Ismo Alanko as well as Freud, Marx, Engels and Jung, among others, will play songs from 13 of AC/DC's 14 albums on February 18 in the Atria ...
All AC/DC songs to be played in Finnish charity event Jan 10, 2006
Newsroom Finland, 17 hours. The Finnish lineup includes Leningrad Cowboys, Quintessence, Emmi, Ismo Alanko and Freud, Marx, Engels & Jung. Live Wire ...
F-Secure Oyj: Announcement pursuant to securities act chapter 2 ... Jan 5, 2006
Kauppalehti (press release), ...from Finnish January 5, 2006 ANNOUNCEMENT PURSUANT TO SECURITIES ACT CHAPTER 2, SECTION 10 F-Secure Corporation has been informed today by Ismo Bergroth that ...
Finnish doctors back health warnings on alcohol bottles Jan 11, 2006
Newsroom Finland, Ismo Tuominen of the Ministry of Health and Social Affairs and Health told the Finnish News Agency (STT) on Tuesday that also the warning label issue was on ...
AC/DC Marathon To Be Held In Finland - Jan. 10, 2006 Jan 10, 2006
Blabbermouth.net, 17 hours. The Finnish lineup includes LENINGRAD COWBOYS, QUINTESSENCE, EMMI, ISMO ALANKO AND FREUD, MARX, ENGELS and JUNG. LIVE ...
Only seven more for the Disaster Victim Identification team Dec 20, 2005
Helsingin Sanomat, ...a container bound for Finland nearly carried two bodies from another country, but we managed to stop it in time", admits Detective Inspector Ismo Kopra, the ...
Take heart, you needn’t spend much on clot bustin’ Jan 12, 2006
Economic Times, Clot busting pill Sorbitrate may become cheaper soon. ... The move could, however, affect the bottomline of Nicholas Piramal India, the maker of Sorbitrate. ...
Christmas tree pickup established at 3 parks Dec 27, 2005
Beaumont Enterprise, Trees stripped of their stands, decorations and any plastics can be left at Rogers Park at Dowlen and Gladys; Sprott Park at Usan and Virginia; and Magnolia ...
Clemson 52, Winthrop 51 Dec 20, 2005
Gainesville Sun, ...usan Yenser's putback in the final second gave Clemson a 52-51 win over Winthrop on Tuesday night. The Lady Tigers (5-6) led 48-37 ...
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