Isoproterenol resources

DRUG INFO
Isoproterenol

Drug Name: Isoproterenol


Indication: For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis



Pharmacology: Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Mechanism Of Action: The pharmacologic effects of Isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Drug Category: Cardiotonic Agents; Bronchodilator Agents; Sympathomimetic; ATC:R03AC

Brand Names/Synonyms: A 21; Aerolone; Aleudrin; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Dihydroxyphenylethanolisopropylamine; Epinephrine Isopropyl Homolog; Euspiran; IPA; Isadrine; Isonorene; Isonorin; Isoprenalin; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol; Isoproterenol Chloride; Isoproterenol Hcl; Isorenin; Isuprel; Isuprel Mistometer; Isupren; L-Isopropylnoradrenaline; L-Isoproterenol; Lomupren; Medihaler-Iso; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Neo-Epinine; Neodrenal; Norisodrine; Norisodrine Aerotrol; Novodrin; Proternol; Respifral; Saventrine; Vapo-Iso; WIN 5162

Dosage Forms: LIQUID

Absorption: Not Available

Interactions: DrugBank: Interactions for Isoproterenol

Interactions for Isoproterenol:

Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias. The drugs may, however, be administered alternately provided a proper interval has elapsed between doses.

ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.





Chemical IUPAC Name: 4-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,2-diol

Chemical Formula: C11H17NO3

Half Life: Not Available

Drug Type: Approved Drug

# Accession No: APRD00182

CAS Registry Number: 7683-59-2