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Isoflurophate
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DRUG INFO
Isoflurophate
Drug Name:
Isoflurophate
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Indication: For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
Pharmacology: Isoflurophate is used as ocular drops in the treatment of chronic glaucoma. Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.
Mechanism Of Action: The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.
Drug Category: Antiglaucomic Agents; Ophthalmics; Cholinesterase Inhibitors; Miotics; Protease Inhibitors; ATC:S01EB
Brand Names/Synonyms: DFP; Diflupyl; Diflurophate; Diisopropoxyphosphoryl Fluoride; Diisopropyl Cyanomethylphosphonate,; Diisopropyl Fluoridophosphate; Diisopropyl Fluorophosphate; Diisopropyl Fluorophosphonate; Diisopropyl Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluorfosfat; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphoric Acid Ester; Diisopropylfluorphosphorsaeureester; Disiopropyl Fluorophosphonate; Dyflos; EA 1152; Floropryl; Fluorodiisopropyl Phosphate; Fluoropryl; Fluostigmine; Fluropryl; HSDB 2133; Humorsol; Isofluorophate; Isofluorphate; Isoflurophate; Isoflurophosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit; O,O-Diisopropyl Fluorophosphate; PF-3; Phospholine Iodide; Rcra Waste No. P043; Rcra Waste Number P043; T-1703; TL 466
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 2-(fluoro-(1-methylethoxy)phosphoryl)oxypropane
Chemical Formula: C6H14FO3P
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00763
CAS Registry Number: 55-91-4
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