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Isoflurane
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DRUG INFO
Isoflurane
Drug Name:
Isoflurane
Indication: For induction and maintenance of general anesthesia
Pharmacology: Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism Of Action: Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Category: Anesthetics; General Anesthetics; ATC:N01AB06
Brand Names/Synonyms: Aerrane; Compd 469; Compound 469; Ethane; Forane; Forene; Isoflurane; Isoflurane [Usan:Ban:Inn:Jan]; Isofluranum [Inn-Latin]
Dosage Forms: LIQUID
Absorption: Not Available
Interactions:
DrugBank: Interactions for Isoflurane
Interactions for Isoflurane:
Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle
relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N2O. See CLINICAL PHARMACOLOGY.
Chemical IUPAC Name: 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane
Chemical Formula: C3H2ClF5O
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00212
CAS Registry Number: 26675-46-7
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Isoflurane News
(When available)
Mangalam supremo MCVarghese is dead Jan 9, 2006
Newindpress, ...morning following a heart attack. The funeral will be held at Lourdes Forane Church cemetery at 4 pm on Tuesday. The body will be ...
MC Varghese laid to rest Jan 10, 2006
Newindpress, The mortal remains of the vernacular media baron was laid to rest at the cemetery of the Lourdes Forane Church here on Tuesday. ...
ACTION BRIEFING Jan 3, 2006
Desert Dispatch, Police could not locate the source of the shots. * At 1:25 am in the 1600 block of Forane Street, police received reports of a woman lying on the ground. ...
(China) Baxter launches generic anesthetic product in China Dec 13, 2005
Biotecheast.com, ...means Baxter is the only company that offers all three modern inhaled anesthetics globally - sevoflurane, Suprane (desflurane, USP) and Forane (isoflurane, USP ...
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