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Isocarboxazid
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DRUG INFO
Isocarboxazid
Drug Name:
Isocarboxazid
Indication: Isocarboxazid is used to treat depression, especially when the patient is excitable or suffering from phobias (fears).
Pharmacology: Isocarboxazid is a non-selective hydrazine monoamine oxidase (MAO) inhibitor used to treat depression. In vivo and in vitro studies demonstrated inhibition of MAO in the brain, heart, and liver. Depression is a complicated disease that is not fully understood. It is thought that depression may be linked to an imbalance of chemicals within the brain. When depression occurs, there may be a decrease in the amount of chemicals released from nerve cells in the brain. These chemicals are called monoamines. Monoamines are broken down by a chemical called monoamine oxidase. Isocarboxazid prevents monoamine oxidase from breaking down the monoamines. This results in an increased amount of active monoamines in the brain. By increasing the amount of monoamines in the brain, the imbalance of chemicals thought to be caused by depression is altered. This helps relieve the symptoms of depression.
Mechanism Of Action: Isocarboxazid works by irreversibly blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system. MAO subtypes A and B are involved in the metabolism of serotonin and catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine. Isocarboxazid, as a nonselective MAO inhibitor, binds irreversibly to monoamine oxidase–A (MAO-A) and monoamine oxidase–B (MAO-B). The reduced MAO activity results in an increased concentration of these neurotransmitters in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. This increased availability of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors.
Drug Category: Antidepressants; ATC:N06AF01
Brand Names/Synonyms: BMIH; Benazide; CHEMBANK3383; Enerzer; Isocarbonazid; Isocarbossazide; Isocarbossazide [Dcit]; Isocarboxazid; Isocarboxazid [Ban:Inn]; Isocarboxazida [Inn-Spanish]; Isocarboxazide; Isocarboxazide [Inn-French]; Isocarboxazidum [Inn-Latin]; Isocarboxyzid; Maraplan; Marplan; Marplon
Dosage Forms: TABLET
Absorption: Well absorbed from the gastrointestinal tract.
Interactions: Interactions for Isocarboxazid:
Isocarboxazid should be administered with caution to patients receiving Antabuse (disulfiram, Wyeth-Ayerst Laboratories). In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death.
Concomitant use of Isocarboxazid and other psychotropic agents is generally not recommended because of possible potentiating effects. This is especially true in patients who may subject themselves to an overdosage of drugs. If combination therapy is needed, careful consideration should be given to the pharmacology of all agents to be used. The monoamine oxidase inhibitory effects of Isocarboxazid may persist for a substantial period after discontinuation of the drug, and this should be borne in mind when another drug is prescribed following Isocarboxazid. To avoid potentiation, the physician wishing to terminate treatment with Isocarboxazid and begin therapy with another agent should allow for an interval of 10 days.
Chemical IUPAC Name: N-benzylamino-5-methyl-oxazole-3-carboxamide
Chemical Formula: C12H13N3O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00701
CAS Registry Number: 59-63-2
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Isocarboxazid News
(When available)
Crime Report for 1/13-1/14 15 Jan 2006
Greenwood Commonwealth, J, shoplifting (arrested by Itta Bena Police Dept.), jailed. Limbrix Conley, 29, 1000 Freedom St., Itta Bena, domestic violence, trespassing, jailed. ...
Price, Valley sink Alcorn; Broomfield boosts MC 15 Jan 2006
Jackson Clarion Ledger, ITTA BENA — Mississippi Valley State made six straight free throws in the final minute to survive Alcorn State's comeback bid Saturday night and the Delta ...
Jaguars top UAPB, 60-58 15 Jan 2006
2TheAdvocate, ...assistant coach Courtney Henderson played on the team as a shooting guard. SU has lost 12 of its last 13 games in Itta Bena, Miss.
Itta Bena looking at charging more for water service Jan 5, 2006
Greenwood Commonwealth, The Mississippi Rural Water Association has been invited to assess Itta Bena's water fees to determine whether they are sufficient. ...
Itta Bena seeks solution for housing inmates Dec 21, 2005
Greenwood Commonwealth, An ongoing debt with Leflore County has Itta Bena aldermen looking for a better solution to housing inmates. The county charges ...
Itta Bena's Toys for Tots Drive ends Friday; donations piling up Dec 16, 2005
Greenwood Commonwealth, ...them are hers. Wrapping presents is Griggs' contribution to Itta Bena's Toys for Tots toy drive, which ends on Friday. The single ...
TxDOT can remove signs blocking the right of way Jan 13, 2006
Victoria Advocate, Area Engineer Randy Bena with the Texas Department of Transportation said he's noticed an increase in the sign problem in the past couple of weeks. ...
France : Natexis gains control over lingerie company Barbara Jan 9, 2006
Fibre2fashion.com, General Manager Hubert Lafont has been promoted to Chief Executive Officer, succeeding Jean-Jacques Bena. Lafont and the founding ...
Martin Luther King Jr. memorial march will be on Sunday Jan 14, 2006
Greenwood Commonwealth, ...others. Also having a holiday will be most employees of the cities of Greenwood and Itta Bena, Leflore County and the state. All ...
Missed free throws doom Alcorn Jan 14, 2006
Alcorn State Sports, ...by Josh Bean/Alcorn State SID. ITTA BENA, Miss. - Alcorn State stepped to the free throw line eight times in the final minute of regulation on Saturday night. ...
Valley knocks off Alcorn Jan 14, 2006
Alcorn State Sports, ...by Josh Bean/Alcorn State SID. ITTA BENA, Miss. - Alcorn State's slide in the SWAC standings continued Saturday night. Mississippi ...
Truck driver electrocuted Jan 8, 2006
Advertiser Adelaide, Gippsland. The accident happened at Bena, near Korumburra, about 120km southwest of Melbourne, about 10.45am (AEDT) today, police said. ...
Truck driver electrocuted Jan 8, 2006
Ninemsn, The accident happened at Bena, near Korumburra, about 120 kilometres south-west of Melbourne, about 10.45am (AEDT)on Monday, police said. ...
WorkSafe to probe electrocution Jan 8, 2006
ABC Regional Online, It is believed the accident happened when the man raised the tray of his tip-truck and hit powerlines while making a delivery to a property at Bena. ...
Truck driver electrocuted Jan 9, 2006
The Age, The accident happened at Bena, near Korumburra, about 120 kilometres south-east of Melbourne, about 10.45am yesterday, police said. ...
Truckie dies in shock Jan 9, 2006
Melbourne Herald Sun, Police said the man, 31, of Giffard West, was delivering lime to a property at Bena, about 120km southeast of Melbourne, when he lost control of his tip-truck ...
Workplace deaths under investigation Jan 9, 2006
ABC Online, A 31-year-old man from Giffard West was electrocuted at Bena in South Gippsland yesterday when the raised tray of his delivery truck brought down powerlines. ...
Laporte loses third straight, fall at Verndale 66-50 Jan 11, 2006
Walker Pilot Independent, It doesn't get any easier for Laporte as they travel to face the undefeated Cass Lake-Bena Panthers Tuesday night (results not known when this issue went to ...
France adopts a lacy, racy lingerie strategy Jan 13, 2006
International Herald Tribune, City, Japan. The Bena family last week sold control of Barbara and Ravage brands to Natexis Private Equity, based in Paris. Making ...
French Bra Makers Fight Chinese Imports With Partners, Ads Jan 12, 2006
Bloomberg Yamaguchi City. The Bena family last week sold control of Barbara and Ravage brands to Paris-based Natexis Private Equity. Making ...
Crime Report for 12/29-12/30 Dec 31, 2005
Greenwood Commonwealth, Paul Pittman, 29, PO Box 293, Morgan City, possession of crack cocaine with intent to distribute (arrested by the Itta Bena Police Department), jailed. ...
People at Play Jan 2, 2006
London Free Press, Mississippi Valley State is a small university of 3,089 undergraduate students attached to an itty-bitty community of 2,200 called Itta Bena -- honest -- in ...
Panthers shoot to avoid near misses Jan 12, 2006
Odessa American, ...“We came in this year and we knew what to do and got it done faster than last year,� said senior Michael Bena-vides, a third-year varsity player who will ...
Vick in the first round? Jan. 10, 2006 Jan 11, 2006
Suffolk News-Herald, ...bena wrote on January 10, 2006 3:24 PM:"I FEEL THAT ANYONE WHO'S NAME APPEARS IN YOUR PAPER UNDER NEWS IS A PUBLIC PERSON AND SHOULD NOT BE CONSIDERED A NON ...
Schools consider random testing Dec 28, 2005
In-Forum (subscription), This week, two Minnesota school districts – Cass Lake-Bena, east of Bemidji, and Forest Lake near the Twin Cities – said they also are considering such a ...
First-year Valley coach forced to shuffle lineup Jan 13, 2006
Jackson Clarion Ledger, ...reasons. It's doubtful either will be in uniform Saturday when Valley (2-10, 2-1 SWAC) hosts Alcorn State (3-10, 3-1) in Itta Bena. ...
Walter 'Bull' Anderson Jan 13, 2006
Greenwood Commonwealth, Lee Anderson of Cedar Rapids; his mother, Emma Glover of Greenwood; nine sisters, Bridget Thomas of Greenwood, Roxanna Coleman of Itta Bena, Deborah Collins ...
Panthers roll past Hillcrest Dec 28, 2005
In-Forum (subscription), Cass Lake-Bena proved Wednesday it can play defense and doesn’t need to score more than 90 points to win games. The run-and-gun ...
Fairbanks gets mad, then even Dec 29, 2005
In-Forum (subscription), Cass Lake-Bena shooting guard Brady Fairbanks wasn’t happy with his team’s performance after Barnesville took a five-point halftime lead Thursday. ...
‘An amazing experience’ Dec 18, 2005
The National, ...our 30th year of Independence, and with the slogan of ‘Putim PNG i go pas’ it was a fitting tribute for a little village, Arufa (in the Bena Bena region of ...
Schools take closer look at random drug testing Dec 27, 2005
Minneapolis Star Tribune (subscription), Supporters plan to ask the Cass Lake-Bena and Forest Lake districts to study the issue. Lawsuits are expected if the policies are approved. ...
Greenwood building gets state landmark designation Dec 19, 2005
Biloxi Sun Herald, Besides the Greenwood building, the Itta Bena City Hall may receive state landmark designation this week. The designation would ...
Zenoba Stuckey Sr. Dec 28, 2005
Greenwood Commonwealth, Services for Zenoba Stuckey Sr., 64, of Itta Bena, who died of heart failure Thursday, Dec. ... Burial will be in Pitts Memorial Gardens in Itta Bena. ...
Man injured in train-auto crash Dec 21, 2005
Walker Pilot Independent, Cass County authorities report a motor vehicle-train collision Sunday morning at about 9:30 am near Bena. The driver was Jesse Seelye, 26, of Bena. ...
Families could get help buying homes Dec 23, 2005
Greenwood Commonwealth, Five Itta Bena families soon could have $75,000 each to place on the purchase of a new home. The Mississippi Development Authority ...
2 school districts consider random drug tests for students Dec 27, 2005
Minneapolis Star Tribune (subscription), ...— Random drug testing could come soon to Cass Lake-Bena and Forest Lake districts as parents and educators look for new ways to combat drug use by teens. ...
Confederate memorial site earns state landmark status Dec 18, 2005
Greenwood Commonwealth, ..."We must keep it not just for the present, but for the future," she said. Itta Bena City Hall could receive its state landmark designation this week. ...
Wrestling Wolves drop two matches Dec 28, 2005
Walker Pilot Independent, The Wrestling Wolves got pins from Nate Higgins, Kyle Sanders and the Crow brothers, but it wasn't enough to hold off Blackduck-Cass Lake-Bena, who got ...
Institute pursues MVSU-Delta connections Dec 20, 2005
Greenwood Commonwealth, ...impacts. Itta Bena Mayor Thelma Collins and the institute are examining whether commerce in downtown Itta Bena is rising or decaying. ...
Attorney pushes to be Native voice in Minnesota Senate Jan 9, 2006
Indian Country Today, ...evening in December, she spoke at a DFL meeting at a bar in Walker before heading to a high school basketball game between archrivals Cass Lake-Bena, her alma ...
Four to interview for superintendent Jan 11, 2006
Lexington Clipper Herald, Chessmore has been the superintendent of three schools and is currently the director of the Cass Lake-Bena school district in Minnesota. ...
COLLEGE WOMEN : UALR falls to Monroe Jan 3, 2006
Arkansas Democrat-Gazette (subscription), Senior Aishie Banks missed the game with a knee injury, while freshman Courtney Carter missed the game with an infection. ITTA BENA, Miss. ... ITTA BENA, Miss. ...
No-frills contracts vital for European operators Jan 9, 2006
Siliconrepublic.com, However, warned Bena Roberts, an analyst specialising in European wireless services for Current Analysis, mobile operators wishing to succeed in 2006 should ...
Laporte holds off scrappy Lady Eagles, 61-57 Jan 11, 2006
Walker Pilot Independent, The Trojans, who came into the game with a big subsection win over Cass Lake-Bena, maintained an eight- to 10-point lead for most of the game. ...
Norman Walker Mangum Jan 8, 2006
Greenwood Commonwealth, ...of Houston, Texas, Steve Mangum of Hong Kong and Carl Britt of Tchula; two sisters, Frances Armstrong of Jackson and Jewell Peoples of Itta Bena; his daughter ...
Megan Zubke achieves 1,000 point milestone Dec 28, 2005
Walker Pilot Independent, ...the 12th Laporte basketball player to score 1,000 points in a career as she scored a career-high 41 points in a 70-56 home win over Cass Lake-Bena last Thursday ...
Crime Report for 12/13-12/14 Dec 15, 2005
Greenwood Commonwealth, Jerrold Hart, 33, 106 Kennedy Drive, Itta Bena, contributing to the delinquency of a minor, false identification, contempt of court, driving with a suspended ...
WHA shows promise, despite lopsided loss to Cass Lake Panthers Dec 15, 2005
Walker Pilot Independent, The Walker-Hackensack-Akeley Wolves showed some promising signs, despite losing their basketball season opener 97-63 to a very talented Cass Lake-Bena (CL-B ...
School board member suggests drug tests for Forest Lake students Dec 15, 2005
Duluth News Tribune, Only the Cass Lake-Bena school district is currently looking at whether to randomly test students in activities. No other school has a drug testing policy. ...
Two Minnesota school districts exploring random drug testing Dec 26, 2005
Minnesota Public Radio, Now, two Minnesota school districts - Cass Lake-Bena and Forest Lake - are exploring the pros and cons of drug testing kids in school. ...
Lakas to discuss FVR proposal on Saturday Jan 10, 2006
Manila Times, BenaÂsing Macarambon of Lanao del Sur, chairman of the Committee on Agriculture, said Ramos might as well focus on helping build a consensus between the House ...
Crime Report from 12/10-12/12 Dec 13, 2005
Greenwood Commonwealth, Belinda Holston, 22, 101 Kristi Lane, Itta Bena, simple assault (arrested by the Itta Bena Police Dept.), jailed. Julia Paulette ...
T-Mobile to Sell Computers Jan 4, 2006
Red Herring, ...“I think that the economics of offering quality laptops with services is a strong upsell possibility,� said Bena Roberts, a Current Analysis analyst who ...
As He Makes Triumphant Entry Into Takoradi Jan 5, 2006
AllAfrica.com, ...people for their support. He also paid a courtesy call on the paramount chief for the Shama area, Nana Kobina Bena. Dressed in local ...
Zubke scores 41, Laporte girls trounce Panthers Dec 28, 2005
Walker Pilot Independent, Seniors Megan Zubke and Stef Smith made sure of that as they combined to score 62 points in a 70-56 win over Cass Lake-Bena last Thursday night. ...
BB King travels road from field to fame Jan 3, 2006
The Express Times, From his earliest boyhood days in Itta Bena on the Mississippi Delta, doing a man's work in the cotton fields at age 7, to the present, King at 80 years young ...
2005 headlines show the year in review Dec 28, 2005
Walker Pilot Independent, WHA boys' and girls' basketball teams play against Cass Lake-Bena at the Target Center. WHA dropped both contests, 45-37 for the girls; and 83-72 for the boys. ...
DELTA DEVILS HOLD OFF GOLDEN LIONS Jan 3, 2006
Pine Bluff Commercial, ITTA BENA, Miss. — Mississippi Valley State University used a huge three-pointer and three clutch free throws during the closing ...
Maurice 'Sonny' Harris Dec 21, 2005
Greenwood Commonwealth, Services for Maurice "Sonny" Harris, 55, of Itta Bena, who died of a heart attack Monday, Dec. 19, 2005, at his home, will be at ...
Competitive spell: Middle School student wins county bee. Dec 17, 2005
Greenwood Commonwealth, Jessica is the daughter of Debra Martin of Itta Bena and Preston Brownlow of Greenwood, and Armena is the daughter of Anne Gamblin and Derrick White, both of ...
Teresa Michelle Harris Dec 16, 2005
Greenwood Commonwealth, 3, 2005, at Arrowhead Medical Center in California, will be at 11 am Saturday at Samuel Chapel United Methodist Church in Itta Bena. She was a homemaker. ...
Top 10 stories for 2005 Jan 1, 2006
Greenwood Commonwealth, Maria Johnson, 22, of Itta Bena and Tiffany Hall, 22, of Greenwood, both MVSU students, were charged with arson in the incident and placed on administrative ...
James McDaniel Jan 4, 2006
Greenwood Commonwealth, Mr. McDaniel retired from General Motors, where he worked for 27 years. He was born in Itta Bena, and moved to St. Louis in 1946. ...
Devils notch first win in SWAC opener Jan 3, 2006
Delta Democrat Times, ITTA BENA - Stanford Speech scored a game-high 17 points, five in the final 39 seconds, to lift Mississippi Valley State to a 68-62 victory over Arkansas-Pine ...
Leflore Democrats try to get going again Dec 15, 2005
Greenwood Commonwealth, Curtis Simmons of Itta Bena, a member of the Leflore County School Board and longtime Democratic activist, said the meeting set a good tone however bringing it ...
Clutch foul shooting carries Jan 3, 2006
Delta Democrat Times, ITTA BENA - Christen West scored 20 points while Portia Wilson added 16 to lead MVSU to a 70-61 victory over Arkansas Pine Bluff on Monday night at the ...
More Indians Taking Part in State Politics Dec 29, 2005
ABC News Irene Folstrom, a Leech Lake tribal member who is running for Minnesota state senate, talks with friends during a basketball game at Cass Lake-Bena High School ...
Indian Women Net ball team arrives Dec 29, 2005
PakTribune.com, Deepali Bisht Player The Pakistan Woman Netball team includes 1. Quratual An Player 2. Naila Farhat Player 3. Aisha Player 4. Bena Chourdy Player 5. Mahreen ...
Relational Says Sovereign Press Release and Sidhu Letter ... Dec 29, 2005
Finanzen.net, Mr. Sidhu praised the credentials of the article's author, BenA. Plotkin, the chairman and CEO of investment banking and brokeragefirm Ryan Beck & Co. ...
Lady Techsters seek to keep momentum going Dec 22, 2005
Shreveport Times, CENTENARY: The Ladies (1-9) will try to break a seven-game winning streak today when they take on Mississippi Valley State (3-3) in Itta Bena, Miss. ...
Laporte boys fall at home to Red Lake, record slips to 3-2 Dec 28, 2005
Walker Pilot Independent, On the other side, Red Lake was simply trying to forget about their 60-point loss to Cass Lake-Bena a week prior, and show they are still a force in the ...
GSU working to solidify non-conference football slate Dec 23, 2005
Monroe News Star, 4). The Tigers are scheduled to travel next year to Alabama A&M in Huntsville (Sept. 9), Mississippi Valley State at Itta Bena (Oct. ...
Krejcir launches book claiming he bribed investigators, judges Dec 12, 2005
Prague Daily Monitor, The most serious charges for which Krejcir is prosecuted are connected to a customs debt of the companies Bena and Tukovy prumysl worth 2.8 billion crowns. ...
Snow gets 24, but Valley stays winless Dec 23, 2005
Jackson Clarion Ledger, ...play. ITTA BENA — The Devilettes (4-3) entered the Christmas break on a winning note, taking an early lead and cruising. Fueled ...
Community Kitchen marks two years' work Dec 23, 2005
Greenwood Commonwealth, The Greenwood-Itta Bena alumnae chapter of Delta Sigma Theta also came out Wednesday to serve hot meals. Members mentor and tutor school-age girls. ...
Spartans tame Lions with victory Dec 28, 2005
Grand Rapids Herald Review, Cass Lake-Bena takes on International Falls in the game’s first semi-final at 6 pm today at the Karen Tomberlin Gymnasium in Coleraine.
AREA WOMEN: Techsters crush Alcorn State Dec 22, 2005
Shreveport Times, CENTENARY 55: At Itta Bena, Miss., playing their fourth game in six days, the Ladies couldn't stay with the Devilettes (4-3) early and suffered their eighth ...
Christmas falls on Sunday Dec 23, 2005
Greenwood Commonwealth, The Rev. Marjorie Walker of Samuel Chapel United Methodist Church in Itta Bena agrees. Her church will have 8 am worship Sunday. ...
Forest Lake student drug tests proposed Dec 15, 2005
Pioneer Press, No Minnesota school now has such a policy, though the Cass Lake-Bena school district is studying whether to randomly test students in extracurricular activities ...
Palmer takes oath Dec 30, 2005
Greenwood Commonwealth, ...hand, too. Greenwood attorney Neysha Sanders, municipal court judge for the city of Itta Bena, administered the oath of office. The ...
St. Peter's curate to be ordained Dec 21, 2005
Albany Times Union, The Rev. David J. Bena, bishop suffragan, will officiate. The sermon will be delivered by the Rev. Michael Lolwerikoi of the Anglican Church of Kenya. ...
Renat Nell Harris Sago Dec 23, 2005
Greenwood Commonwealth, St. Luke Church of God in Christ in Moorhead. Mrs. Sago was the first lady of St. Rest Church of God in Christ in Itta Bena. She ...
Minnesota Fishing Report Dec 16, 2005
In-Forum (subscription), There hasn't been much of a deep water perch bite, but there are walleyes being taken off Bena Bar during the evening hours in 22 to 26 feet of water. ...
Delta duo's bottle tree business growing fast Dec 26, 2005
Jackson Clarion Ledger, It's art," said Sabin, who welds and shapes the trees from iron rods, working inside a farm shop near Mississippi Valley State University at Itta Bena. ...
Cold weather helps some retailers Dec 28, 2005
Greenwood Commonwealth, ...did in 2004. Matlean Bewards of Itta Bena also said her spending patterns haven't changed that much from last year. Bewards was ...
Laporte wins first game of season, beats host Tigers 57-48 Dec 15, 2005
Walker Pilot Independent, Laporte played a solid first half and trailed by only three points against Cass Lake-Bena, the reigning Class A third-place team. ...
Cass County court news Dec 28, 2005
Walker Pilot Independent, ...degree criminal sexual conduct. He sexually assaulted a teenage girl who was walking on a trail near Bena last August. Tammy Jo Newman ...
Higher utility costs coming Dec 16, 2005
Greenwood Commonwealth, This month they met at The Alluvian. The city of Itta Bena is also a member of the agency as are the cities of Canton, Kosciusko, Durant and Leland. ...
Anytown Club to put on first Diversity Day Dec 21, 2005
Paly Voice, January 2005 with the assistance of Kris Brockmann, the advisor for Any Club, the club devoted to promoting Camp Anytown, and Mary Ellen Bena, the secretary of ...
Empowerment Zone operations look promising, director says Dec 17, 2005
Greenwood Commonwealth, Itta Bena received a large portion of Leflore County's MDEZA grant funds. This included $18,119 to the police department and $200,000 to the fire department. ...
Three women drown in EHP Dec 14, 2005
The National, ...and fish ponds. He said the river runs 30km from Kwongi in the upper Asaro valley to Keiya in the Unggai-Bena area. He said the ...
Sleep is the best Rx for cold, flu Dec 20, 2005
Appleton Post Crescent, ...class (MAOI). Examples are isocarboxizide (Marplan), phenelzine (Nardil), tranylcypromine (Parnate) and St John' s Wort. Cough from ...
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