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Immune globulin
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DRUG INFO
Immune globulin
Drug Name:
Immune globulin
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Indication: For treatment of immunodeficiencies, thrombocytopenic purpura, Kawasaki disease, gammablobulinemia, leukemia, bone transplant
Pharmacology: Used as a replacement therapy in inherited humoral immunodeficiency disorders such as severe combined immunodeficiency syndrome, x-linked agammaglobulinemia, and Wiskott-Aldrich Syndrome. The immune globulins target, bind and kill bacterial cells as well as viral particles. IgG is the monomeric immunoglobulin of which there are four subclasses (IgG1, IgG2, IgG3 and IgG4) in differing abundances (66%, 23%, 7% and 4%). IgAs represent about 15% of the immunoglobulins in the blood. These target inhaled or ingested pathogens.
Mechanism Of Action: Antibodies prevent infection by attaching to the surface of invading pathogens and aiding in their disposal before they can infect cells. Antibodies remove pathogens via complement activation, agglutination or precipitation, pathogen receptor blocking, macrophage “tagging� or neutralization (via binding) of pathogen toxins.
Drug Category: Immunomodulatory Agents; Anti-infectives; serums (80:04.00)
Brand Names/Synonyms: Ig alpha-2 chain C region; Flebogamma (Instituto Grifols SA); Gamunex (Talecris Biotherapeutics)
Dosage Forms: SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human antibodies
Chemical Formula: C6332H9826N1692O1980S42 >IgA2
Half Life: >20 hours (mammalian reticulocytes, in vitro).
Drug Type: Approved Drug
# Accession No: BIOD00091
CAS Registry Number: Not Available
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