Indication: For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna
Pharmacology: Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mechanism Of Action: After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily due to cross-linking of strands of DNA and RNA, as well as inhibition of protein synthesis.
Drug Category: Antineoplastic Agents; Immunosuppressive Agents; ATC:L01AA06
Interactions:
DrugBank: Interactions for Ifosfamide
Interactions for Ifosfamide:
The physician should be alert for possible combined drug actions, desirable or undesirable, involving ifosfamide
even though ifosfamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.
Chemical IUPAC Name: N,3-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine
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