Indication: For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Pharmacology: Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Mechanism Of Action: Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Drug Category: Antipruritics; Histamine H1 Antagonists; Anxiolytics sedatives and hypnotics; ATC:N05BB01
Absorption: Rapidly absorbed from the gastrointestinal tract
Interactions:
DrugBank: Interactions for Hydroxyzine
Interactions for Hydroxyzine:
THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL
NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore when central
nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.
Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned
against driving a car or operating dangerous machinery while taking Atarax. Patients should be advised against the
simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased.
Chemical IUPAC Name: 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
Chemical Formula: C21H27ClN2O2
Half Life: 20 to 25 hours
Drug Type: Approved Drug
# Accession No: APRD00688
CAS Registry Number: 68-88-2
Hydroxyzine News (When available)
15-day-old baby needs helpJan 10, 2006 Visayan Daily Star, ...child. Dr. Lily Alamon, resident-in-charge of the CLMMRH nursery, said John Jedrick was delivered Dec. 13 through Ceasarian section. ...
Army seals off the W. Bank, bars in PalestiniansJan 13, 2006 International Middle East Media Center, ...figured it out at the permanent so-called "portable checkpoints" that barred them over the past four weeks from traveling south from the Za'atara junction in ...
Later-baby mothers earn 10% moreDec 17, 2005 The Sunday Times, Miller is hesitant about identifying the perfect age for motherhood but Atara, her younger sister, has given considerable thought to the subject. ...
Israel braced for loss of its grandfatherJan 5, 2006 Guardian Unlimited, ...memories. "If he dies, I won't be upset," said 18- year-old Daniel Slomnicki, a religious student sipping coffee at Cafe Atara. ...
Twilight Zone / Theater of the absurdDec 15, 2005 Ha'aretz (subscription), Tour and enjoy. The checkpoint at the exit from Bir Zeit is not manned today; there is increased easing of the closure. The Atara bridge. ...
Rollercoaster Tycoon 3: Wild! Update 2Dec 20, 2005 Boomtown, Atara is ready with a new patch for the expansion pack Wild!, for their Rollercoaster Tycoon 3 game. This new patch adresses a series ...
Protalix Biotherapeutics raises $7.6mDec 26, 2005 Globes, ...led by Tamares Capital (controlled by Poju C. Zabludowicz) , Docor International BV (a subsidiary of the Van Leer Foundation), and Atara Technology Ventures Ltd ...
Reimbursement Regulations Underline the Need for Innovative ...Jan 9, 2006 PR Newswire UK (press release), Moroever, the existing restraints in the market can be overcome if efforts are made to develop better links with the Association for Parenteral and Enteral ...
Tainted pet food raising concernsJan 14, 2006 Gainesville Times, ..."This particular dog is on total parenteral nutrition (being fed through a stomach tube) because he had so much vomiting," Sanderson said. ...
FDA Sends Warning for WinRho SDF (Rho(D) Immune Globulin ...Jan 6, 2006 PharmaLive.com (press release), ...pyrroloquinolinequinone (GDH-PQQ) or glucose-dye-oxidoreductase methods) in patients who have received maltose-containing parenteral products including WinRho ...
FDA Approves Taclonex(R) - Once Daily Therapy for Treatment of ...Jan 10, 2006 PR Newswire (press release), Headquartered in Denmark, LEO Pharma is among the world's leading companies in topical dermatology and parenteral treatment of thromboembolic disorders. ...
Baxa announces EU switch in sales and marketingJan 9, 2006 In-PharmaTechnologist.com, ...provides systems and products that streamline pharmacy operations for oral liquid delivery, sterile IV preparation and mixing multi-source parenteral solutions ...
Immersion Medical Joins with PICC Excellence to Promote Training ...Jan 9, 2006 Business Wire (press release), Peripherally inserted central catheters are used to provide prolonged intravenous access for dispensing total parenteral nutrition to neonates, and antibiotics ...
Update on Gout and Other Crystal-Induced ArthritidesJan 5, 2006 Medscape (subscription) First, dietary hypomagnesemia was identified as a significant risk factor for chondrocalcinosis in subjects on long-term parenteral nutrition, even with ...
Androgen Deprivation Affects Memory in Prostate Cancer PatientsJan 4, 2006 Cancerpage.com, ..."While it is premature to recommend parenteral estradiol as an alternative to conventional androgen deprivation therapy, these data support the further study ...
Flexpoint Partners Announces Acquisition of Midatlantic Home ...Jan 5, 2006 PR Newswire (press release), ...has particular expertise in treating complex patients requiring inotropic/cardiac therapies, intravenous immunoglobulin (IVIG), total parenteral nutrition and ...
Figures hard to digestDec 19, 2005 Belfast Telegraph, Furthermore, a report by the British Association of Parenteral and Enteral Nutrition claims about 30% of patients in nursing homes and hospitals are clinically ...
Wyeth and Progenics Pharmaceuticals Announce Worldwide ...Dec 23, 2005 Business Wire (press release), Progenics will lead the US development of subcutaneous and intravenous MNTX, while Wyeth will lead development of these parenteral products outside the US ...
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