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Hesperetin
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DRUG INFO
Hesperetin
Drug Name:
Hesperetin
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Indication: For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again
Pharmacology: Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%
Mechanism Of Action: Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
Drug Category: Anticholesteremic Agents
Brand Names/Synonyms: Cyanidanon 4'-Methyl Ether 1626; Hesperetin; Hesperin; Hesperitin; YSO2
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-chroman-4-one
Chemical Formula: C16H14O6
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00117
CAS Registry Number: 520-33-2
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