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Gramicidin D
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DRUG INFO
Gramicidin D
Drug Name:
Gramicidin D
Indication: For treatment of skin lesions and surface wounds
Pharmacology: Gramicidin is particularly effective against gram-positive bacteria. Because the drug is highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment. It is used primarily in the treatment of infected surface wounds, and in eye, nose, and throat infections. It is normally given with two other antibiotics (neomycin and polymixin B) as an ophthalmic solution
Mechanism Of Action: Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization. This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.
Drug Category: Antibiotic Agents; Anti-Infectives
Brand Names/Synonyms: Neosporin; Neosporin (Pfizer)
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Bacillus brevis gramicidin D
Chemical Formula: C99H140N20O17
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00036
CAS Registry Number: 1405-97-6
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Gramicidin D News
(When available)
Woman to serve 2 years Jan 11, 2006
Lynchburg News and Advance, ...incontinent. She also said she treated her mother’s bedsores with Neosporin and took her mother to the doctor regularly. Assistant ...
Physician and student travel to DR on medical trip Jan 9, 2006
Dominican Today, ...medicines, vitamins (child, adult, pre-natal, calcium chews), personal hygiene items and first aid supplies (like plastic bandages, Neosporin, alcohol swabs ...
Cutting a deal Jan 4, 2006
Flint Journal, ...pain. I can hurt myself and then make myself feel better.' I'd meticulously take care of my wounds with peroxide and Neosporin.".
Keep right medications in cabinet Dec 31, 2005
Daily News Journal (subscription), Those are antiseptic rinses. Then you put on some Neosporin.". To top off those surface wounds, basic adhesive bandages in various sizes are also a must-have. ...
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