|
Glimepiride
resources
|
|
|
|
|
|
DRUG INFO
Glimepiride
Drug Name:
Glimepiride
Indication: For concomitant use with insulin for the treatment of noninsulin-dependent (Type II) diabetes mellitus; For the treatment of hyperglycemia that cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent
Pharmacology: Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.
Mechanism Of Action: The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.
Drug Category: Immunosuppressive Agents; Hypoglycemic Agents; Antiarrhythmic Agents; Sulfonylureas; ATC:A10BB12
Brand Names/Synonyms: Amarel; Amaryl; CCRIS 7083; CHEMBANK1624; Endial; Glimepirid; Glimepirida [Spanish]; Glimepiride; Glimepiride [Usan:Ban:Inn]; Glimepiridum [Latin]; Glimepride; HOE 490
Dosage Forms: Oral tablets with various strengths
Absorption: completely (100%) absorbed
Interactions: Many other medicines may increase or decrease the effects of glimepiride or affect your condition. Before taking
glimepiride, tell your doctor if you are taking any of the following medicines:
¡¤ aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others),
choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);
¡¤ a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen
(Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin),
nabumetone (Relafen), oxaprozin (Daypro), and naproxen (Anaprox, Naprosyn, Aleve);
¡¤ a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin),
or sulfasalazine (Azulfidine);
¡¤ a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil);
¡¤ a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor),
and others;
¡¤ a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others;
¡¤ a steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone
(Prelone, Pediapred, others), and others;
¡¤ a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine),
promethazine (Phenergan), and others;
¡¤ phenytoin (Dilantin);
¡¤ isoniazid (Nydrazid);
¡¤ rifampin (Rifadin, Rifamate); or
¡¤ over-the-counter cough, cold, allergy, or weight loss medications.
You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with glimepiride or affect your condition. Talk to your doctor
and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Chemical IUPAC Name: 3-ethyl-N,N-bis(3-ethyl-4-methyl-2-oxo-5H-pyrrol-2-yl)-4-methyl-2-oxo-5H-pyrrole-1-carboxamide
Chemical Formula: C24H34N4O5S
Half Life: ~5 hours following single dose
Drug Type: Approved Drug
# Accession No: APRD00381
CAS Registry Number: 93479-97-1
|
|
|
|
|
|
Glimepiride News
(When available)
It’s all in the name Dec 28, 2005
Calcutta Telegraph, ...changed. As it happened when the diabetes drug Amaryl was confused with the Alzheimer’s medicine Reminyl, and one person died. ...
A Quick Guide for using www.medicare.gov Dec 27, 2005
Paynesville Press, ...a day for his heart; furosemide (40 mg) twice a day for his heart; coumadin (5 mg) once a day for atrial fibrilation and to prevent heart failure; amaryl (4 mg ...
|
|
|
