Indication: For treatment of serious infections caused by susceptible strains of the following microorganisms: P.aeruginosa, Proteus species (indole-positive and indole-negative), E.coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcu
Pharmacology: Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Mechanism Of Action: Aminoglycosides like Gentamicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Absorption: Injections lead to peak serum concentrations in 30-60 minutes. May also be applied as a topical cream or ophthalmic. The drug is actively transported across the bacterial membrane
Interactions:
DrugBank: Interactions for Gentamicin
Interactions for Gentamicin:
No information provided.
Chemical IUPAC Name: 2-[4,6-diamino-3-[3-amino-6-(1-methylaminoethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-methylamino-tetrahydropyran-3,5-diol
Chemical Formula: C21H43N5O7
Half Life: 3-3.5 hours
Drug Type: Approved Drug
# Accession No: APRD00214
CAS Registry Number: 1403-66-3
Gentamicin News (When available)
Apogen TechnologiesJan 2, 2006 Washington Post, How to submit your rsum: Mail to 7450-B Boston Blvd., Springfield, Va. 22153 or apply online at company Web site. Benefits, compensation ...
Apogen chooses director of civilian governmentJan 4, 2006 FCW.com Tim Green, the group manager of Apogen Technologies' defense systems group, has been promoted to group vice president and general manager of the company’s ...
Entrepreneur donates $1M to D-Day MuseumJan 13, 2006 BizNewOrleans.com, Savoie retired in August, 2004 as CEO of Science & Engineering Associates (SEA) and vice-chairman of its parent company, Apogen Technologies. ...
Tech council schedules homeland security eventJan 13, 2006 BizNewOrleans.com, ...conference is the fifth in a series offered by the Technology Council and is sponsored by Rivada Networks, the Whitney National Bank, Apogen Technologies and ...
IAC forms new interest groupsDec 30, 2005 Washington Technology, ...(vice chair). Homeland Protection: Tom Ragland, Apogen Technologies Inc. (chair) and Chris D’Ascenzo, Lockheed Martin Corp. (vice chair). ...
UT sweetens VAT pillDec 16, 2005 Chandigarh Newsline, LIFE-SAVING drugs like intravenous fluids, injections of Texamethasone and Betamethasone and injectible antibiotics like Gentamysin, Metronidizole, and ...
Allergic ReactionsJan 12, 2006 TheHorse.com, ...hypersensitivity. Attard immediately started the horse on IV fluids and banamine, with gentocin and atropine administered to the irritated eyes. ...
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