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Gemfibrozil
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DRUG INFO
Gemfibrozil
Drug Name:
Gemfibrozil
Indication: For treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort
Pharmacology: Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia.
Mechanism Of Action: Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.
Drug Category: Antilipemic Agents; Fribic Acid Derivatives; ATC:C10AB04
Brand Names/Synonyms: Apo-Gemfibrozil; Ausgem; Bolutol; Brozil; CCRIS 318; CHEMBANK796; CI 719; CI-719; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gem-S; Gemd; Gemfibril; Gemfibromax; Gemfibrozil; Gemfibrozil [Usan:Ban:Inn]; Gemfibrozilo [Inn-Spanish]; Gemfibrozilum [Inn-Latin]; Gemlipid; Gemnpid; Gen-Fibro; Genlip; Gevilon; Gevilon Uno; Gozid; Hidil; Hipolixan; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Low-Lip; Micolip; Normolip; Novo-Gemfibrozil; Nu-Gemfibrozil; Pilder; Po-Gemfibrozil; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; TEVA-A; Taborcil; Tentroc; Trialmin; Uno; Wl-Gemfibrozil; [Usan:Ban:Inn]
Dosage Forms: CAPSULE; TABLET
Absorption: Well absorbed from GI after oral administration (within 1-2 hours)
Interactions:
DrugBank: Interactions for Gemfibrozil
Interactions for Gemfibrozil:
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Chemical IUPAC Name: 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Chemical Formula: C15H22O3
Half Life: 1.5 hours
Drug Type: Approved Drug
# Accession No: APRD00293
CAS Registry Number: 25812-30-0
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Gemfibrozil News
(When available)
KANA Response Selected for Integration into Gem Contact Center ... Jan 12, 2006
TMCnet With each client possessing its own service guarantees, working processes and reporting needs, gem’s management must be able to satisfy each of the ...
International Finance Corporation and Kauffman Foundation Launch ... Jan 10, 2006
WebWire (press release), The primary focus of GEM’s work for the first two years is Sub-Saharan Africa. For additional information about IFC-GEM’s programs ...
BETTER BUSINESS BUREAU: Tips on buying jewelry Jan 14, 2006
Asheville Citizen-Times, Make sure the jeweler writes on the sales receipt all the information you relied on when making your purchase, such as the gem’s weight or size. ...
Tanzanian gem sets example for African mining Jan 7, 2006
Business Online, ...local miners as much as the company. The gem’s history reflects that of the country as a whole. Within months of its discovery in ...
Demonic verses Jan 3, 2006
Lucknow Newsline, Shadow in west Imokoi, stood Izakar, the new Dark Tower, an architectural masterpiece built for the new Dark Lord on the foundations of Danh-Gem’s tower by ...
Forever Elegance well tuned Jan 12, 2006
Hindu, Mixed Blessings (Karan) 8 Narasimha 53.5, 7. Pacific Pride (Karan) 1 Shakti 53.5, 8. Symbol Of Speed (Lokanath) 2 C. Stefan 53.5, 9. Amazing Gem (S. Narredu) 6 ...
Part Two of the GameWorld Trilogy Dec 15, 2005
Hindustan Times, Danh-Gem’s heir, Kirin half-ravian, for the very first time. Their secret deliberations this night are going to shake the very foundations of the world. ...
Gem Plumbing institutes long-term wellness plan Dec 30, 2005
Providence Business News, Gem’s 325 employees make for a good-sized company – not too small and not too large – to try new programs that can provide a model for other companies ...
Martin County golf scores: January 12 Jan 12, 2006
Vero Beach Press-Journal (subscription), B Flight, Low Gross: 1, Lou Lipira, 81; 2 (tie), John Vallario, Bill Rezedes, 86; Low Net: 1 (tie), Don Woodworth, Wayne O'Connnor, 67; 2, Don Moraski, 68. ...
St. Lucie County golf scores: January 5 Jan 5, 2006
Vero Beach Press-Journal (subscription), Closest to Pin (4): Lou Lipira, George Zukowski, Dennis Pride, Eileen Eiler. Closest to Pin (7): Jim Koontz, Joe Marmo, Jane Wiersma, Jean Collins. ...
Tatum named new MSSU football coach Dec 14, 2005
Carthage Press, Committee members include players Elbert Johnson and Tyler White; Dean Collins, Tom Cox, John Tupper, Kevin Griem, Dr. Pat Lipira, Dr. Virginia Lass and Robert ...
Unlocking the Diabetes-Heart-Disease Connection Jan 9, 2006
New York Times, Drugs like TriCor and Lopid, cholesterol-lowering drugs called fibrates that are used to treat atherosclerosis, act by regulating lipids. ...
Sison: Bill expands grounds for legal separation Jan 3, 2006
Sun.Star, Bactrim Adult 400/80mg tab, whose generic name is cotrimoxazole; the cardiac drug Adalat Retard 20mg tab (Nifedipine); the liprotropic Lopid 3200mg cap; the ...
Heart attack shock as guard collapses Jan 13, 2006
Electric New Paper, Said cardiologist Dr Low Lip Ping, chairman of the Singapore Heart Foundation: 'Paramedics are trained to look at the recording of the heart rhythm. ...
Puppy fat not cute in adult heart patients Jan 5, 2006
Channel News Asia, ...colorectal cancer. So, it is important to tackle obesity early in life," said the foundation's chairman, Dr Low Lip Ping. The risk ...
Heart Foundation plans more financial help for needy patients Jan 5, 2006
Channel News Asia, Said Dr Low Lip Ping, chairman of the Singapore Heart Foundation, "We find that some patients, after a few events like a heart attack, may need more money to ...
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