Indication: For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS).
Pharmacology: Ganciclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), Ganciclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Ganciclovir into Ganciclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Ganciclovir triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Mechanism Of Action: Ganciclovir stops replication of herpes viral DNA in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. Ganciclovir targets HSV and VSV thymidine kinase
Drug Category: Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB06; ATC:J05AB14;
Dosage Forms: CAPSULE; IMPOLANT; POWDER FOR SOLUTION
Absorption: Poorly absorbed orally, bioavailability is 6% to 9%
Interactions:
DrugBank: Interactions for Ganciclovir
Interactions for Ganciclovir:
No drug interactions have been observed with the Vitrasert Implant. There is limited experience with use of
retinal tamponades in conjunction with the Vitrasert Implant.
Chemical IUPAC Name: 2-[(2-amino-6-hydroxy-purin-9-yl)methoxy]propane-1,3-diol
Chemical Formula: C9H13N5O4
Half Life: 2.5 to 3.6 hours
Drug Type: Approved Drug
# Accession No: APRD00263
CAS Registry Number: 82410-32-0
Ganciclovir News (When available)
Detecting "Masked" Hypertension16 Jan 2006 Saturday Evening Post, Appetizers: enjoy low-fat crackers and cheese, and fresh vegetables with a healthy yogurt dip mixed with dill, basil, or pre-mixed low-sodium seasonings. ...
Nutrition Notes: Men: What Eating Group Are You In?16 Jan 2006 Kansas City infoZine, Their excessive sodium intake (from many processed foods) and low potassium intake (from few vegetables and fruits) are probably related. ...
Light and Easy Lemon Chicken16 Jan 2006 Arizona Republic, Each serving contains approximately: 247 calories; 8 g fat; 104 mg cholesterol; 149 mg sodium; 4 g carbohydrates; 41 g protein; negligible fiber.
For Women: Friends and pets are Good for the Heart16 Jan 2006 Saturday Evening Post, Avoid salt. Read food labels carefully and check your medicine cabinet--Alka-Seltzer, Aleve, and most antacids contain forms of sodium. ...
The Amazing Heart16 Jan 2006 Saturday Evening Post, ...right). The electrical impulse is due to the flow of ions, mainly sodium, potassium, and calcium, in and out of the cells. This ...
Recipe: Shortbread cookies16 Jan 2006 The Grand Rapids Press, ...per each 1-inch square: 22 calories, 0 grams protein, 1 gram fat, 3 grams carbohydrate, 0 grams fiber, 2 milligrams cholesterol, 12 milligrams sodium.
Desktop diners should keep food safety in mind16 Jan 2006 Toledo Blade, Dash. The 2005 USDA Dietary Guidelines urged Americans to decrease sodium consumption to no more than 2,300 mg per day. Currently ...
Genelabs suffers setback on lupus drug16 Jan 2006 Pharma Times (subscription), And earlier in 2005, La Jolla Pharmaceuticals had to shed staff after failing to win approval fort Riquent (abetimus sodium), a treatment for lupus kidney ...
Fastlane: Recipes for busy cooks16 Jan 2006 The Courier-Journal, ...its parts. The secret to its flavor boost: reducing a lot of low-sodium chicken broth to a highly flavorful one-half cup. You could ...
Recipe: White chocolate cranberry cheesecake16 Jan 2006 The Grand Rapids Press, Nutrition information: 411 calories, 7 grams protein, 29 grams fat, 30 grams carbohydrate, 0 grams fiber, 126 milligrams cholesterol, 302 milligrams sodium. ...
GMT: Monday, Jan. 1616 Jan 2006 WFAA (subscription), It makes no sense! Choose either lotion-based cleansers or gel cleansers that avoid the harsh ingredient, Sodium Laureth Sulfate. ...
Oatmeal Pancakes16 Jan 2006 Kansas City infoZine, Per pancake: 78 calories, 1 g. total fat (less than 1 g. saturated fat), 13 g. carbohydrate, 4 g. protein, 1 g. dietary fiber, 157 mg. sodium.
Lamb chops teriyaki16 Jan 2006 Munster Times, Nutrition information per serving: 390 cal., 8 g total fat (3 g saturated), 90 mg chol., 615 mg sodium, 52 g carbo., 6 g dietary fiber, 27 g pro.
DRAXIS Receives FDA Approval for Diagnostic Iodine I-131 CapsulesJan 13, 2006 CNW Telbec (Communiqués de presse), DAX) (NASDAQ: DRAX) has received approval from the US Food and Drug Administration (FDA) regarding its supplemental new drug application for Sodium Iodide I ...
Patrol Identifies Victim In Tanker CrashJan 13, 2006 Yankton Daily Press, Highway Patrol on Friday released the name of a Washington state man who was killed when his pickup truck collided with a tanker carrying liquid sodium cyanide ...
First-Time Generic Approvals: Phenergan Tablets, Floxin Otic ...Jan 4, 2006 Medscape (subscription) ...ofloxacin 0.3% otic solution for the treatment of certain ear infections caused by designated strains of susceptible microorganisms; and sodium bicarbonate 7.5 ...
Company Says FDA OKs Sodium Level DrugDec 30, 2005 Los Angeles Times, WASHINGTON -- The FDA has approved an intravenous drug for hospital patients suffering from potentially life-threateningly low sodium levels, the drug's ...
Sodium Intake Far Too High for AmericansDec 19, 2005 Newswise (press release) Newswise — Despite counseling by physicians, Americans still consume far too much sodium, putting them at risk for high blood pressure, heart disease and ...
Gold Miners and Sodium CyanideDec 27, 2005 Kommersant, ...“This mining company, a consumer and importer of sodium cyanide, believes that there are no grounds ... Korund is the sole Russian producer of sodium cyanides. ...
Too much sodium ingested in USDec 20, 2005 United Press International ATLANTA, Dec. 20 (UPI) -- A study finds that sodium intake is far too high in the United States, and counseling by doctors appears to make little difference. ...
Company Gets FDA Approval for Drugs to Treat Low-SodiumDec 30, 2005 All Headline News Inc. said Friday that the FDA has approved a new drug for hospital patients suffering from life-threatening low sodium levels. The ...
Company Says FDA Has OK'd its Sodium Treatment DrugDec 31, 2005 HealthCentral.com US Food and Drug Administration has approved an intravenous drug for hospital patients suffering from potentially fatal depressed levels of sodium, the drug's ...
Many diuretics users lack key mineralsJan 13, 2006 Monsters and Critics.com, But diuretics can also cause potentially severe health problems in some people by stripping the body of sodium and potassium, according to a new study in the ...
Too Much Sodium!Dec 25, 2005 Ivanhoe, ...(Ivanhoe Newswire) -- A new study reveals Americans consume far too much sodium, even if they already have high blood pressure and despite getting advice from ...
Synthetic Sodium TransporterDec 28, 2005 Chemical & Engineering News Researchers have taken a step closer to a new type of synthetic ion channel with a G-quadruplex that acts as a sodium transporter (J. Am. Chem. Soc. ...
DRAXIS Receives FDA Approval for Diagnostic Iodine I-131 CapsulesJan 13, 2006 PharmaLive.com (press release), ...has received approval from the US Food and Drug Administration (FDA) regarding its supplemental new drug application for Sodium Iodide I-131 Capsules USP ...
Making Lemonade Out of Real Lemons Ross E. GetmanJan 14, 2006 Opinion Editorials, There is speculation that the benzene traces originated from the sodium benzoate by way of photolytic degradation. Koala Springs ...
Keeping a stealth killer at bayJan 13, 2006 Frontiersman (subscription), People with hypertension can help keep their blood pressure levels by adhering to a diet low in sodium (which causes fluid retention and thereby boosts blood ...
One in five patients on commonly prescribed diuretics have ...Jan 11, 2006 I-Newswire.com (press release) 21 per cent of patients on commonly prescribed diuretics for blood pressure and heart problems end up with lowered sodium and potassium levels, which can lead ...
US court approves Wyeth-Teva settlement on EffexorJan 15, 2006 Globes, Teva has also announced tentative FDA approval for its Divalproex Sodium Delayed-Release Tablets USP, 125 mg, 250 mg and 500 mg. ...
Company Says FDA OKs Sodium Level DrugDec 30, 2005 MSN Money WASHINGTON (AP) - The FDA has approved an intravenous drug for hospital patients suffering from potentially life-threateningly low sodium levels, the drug's ...
Company Says FDA OKs Sodium Level DrugDec 30, 2005 ABC News WASHINGTON Dec 30, 2005 — The FDA has approved an intravenous drug for hospital patients suffering from potentially life-threateningly low sodium levels, the ...
Americans Consume Far Too Much Salt and SodiumDec 20, 2005 MedIndia, Americans consume far too much sodium, putting them at risk for high blood pressure, heart disease and stroke, according to a new study published in the ...
Three steps to better healthJan 14, 2006 Scotsman, Sodium is the component in salt that gives cause for concern, as it contributes to high blood pressure, heart disease and strokes. ...
Diuretics may decrease electrolytes levelJan 14, 2006 MedIndia, Thiazide diuretics which are prescribed for preventing strokes have been found to reduce electrolytes sodium and potassium which may cause low blood pressure ...
DRAXIS Receives FDA Approval for Diagnostic Iodine I-131 CapsulesJan 13, 2006 Yahoo! News (press release) NASDAQ: DRAX - News) has received approval from the US Food and Drug Administration (FDA) regarding its supplemental new drug application for Sodium Iodide I ...
Meals on Wheels seeks volunteersJan 13, 2006 Johnson County Sun, ...clients. * Lowered sodium - 800 milligrams or less of sodium per day. No high sources of sodium such as ham or sausage. * Carbohydrate ...
Buying Meat: Are You Getting What You Pay For?Jan 13, 2006 CBS4Boston, All types of cuts are now enhanced with a mixture of water, salt and sodium phosphate. ... Another concern is the high level of sodium in this solution. ...
Laser Vision Lets Astronomers See Clearer, FainterJan 13, 2006 Newswise (press release) Newswise — A new sodium laser is giving 50 times more sky coverage to the atmospheric-correcting technology known as adaptive optics on the Keck II telescope ...
Fears raised over diuretic drugsJan 11, 2006 Health Sentinel Doctors are being urged to monitor people to whom they prescribe diuretics after a study linked the drugs to low sodium and potassium levels. ...
Foods that once were bad are now goodJan 9, 2006 Newsday, Now, it has turned out that sodium nitrate in preserved meats may help preserve the people who eat it, that ice cream improves your mood, that popcorn counts ...
Try pork: It's fast-cooking comfort foodJan 10, 2006 Richmond Times Dispatch, ...unseasoned grill and oven-ready pork tenderloins that are, according to one label, "enhanced with up to 10 percent of a solution of water, sodium lactate, salt ...
INTERTRIGO COMES FROM SKIN RUBBING AGAINST SKINJan 4, 2006 Charlotte Sun-Herald, Also, is it safe to drink water to which sodium has been added? ... The sodium question depends on how much sodium the water softener adds to the water. ...
Health Stocks in MotionJan 13, 2006 TheStreet.com Shares of Draxis Health (DRAX:Nasdaq - commentary - research - Cramer's Take) rose 2% after the company's new drug application for diagnostic sodium iodide I ...
Wyo. crash spills toxic chemicalJan 13, 2006 Rapid City Journal, CASPER, Wyo. (AP) - A crash involving a pickup truck and a tanker truck carrying toxic liquid sodium cyanide killed ... Sodium cyanide can be fatal if ingested. ...
Regional News BriefsJan 13, 2006 Milwaukee Journal Sentinel (subscription), ...old girl at his Mequon home in 2001 and 2002; tried to persuade a 20-year-old woman last September to touch her tongue with a tablet of sodium hydroxide, an ...
Group To Investigate Fatal Wastewater Plant ExplosionJan 14, 2006 Local6.com, Plant when employees who were working to repair a metal roof damaged by last year's hurricanes, used a cutting torch near methanol and sodium sulfate tanks. ...
Weekly calendarJan 14, 2006 Durham Herald Sun, Will discuss and sign, "The Rice Diet Solution: The World-Famous Low-Sodium, Good-Carb, Detox Diet for Quick and Lasting Weight Loss." Thursday, 7 pm. ...
Rick SteelhammerJan 14, 2006 Charleston Gazette (subscription), ...vogue. This time, the trend favored thick glasses, receding hairlines, relaxed-fit Dockers, and high-sodium salt-and-pepper hair. ...
Baking soda has its purposes, but no substituteJan 15, 2006 Scripps Howard News Service, Baking soda, also known as sodium bicarbonate, has a number of functions in baking: it acts as a leavener as well as a browning agent. What does that mean? ...
Lantibio, Inc. and TRB Chemedica Announce Agreement for US ...Jan 12, 2006 CNW Telbec (Communiqués de presse), ...supply/manufacturing agreement for the US development and marketing of VISMED(R). VISMED(R) is a patented formulation containing sodium hyaluronate, currently ...
Science casts mushrooms in healthful lightJan 15, 2006 Kentucky.com, These noodles contain no cholesterol, yet they have the same taste and texture as egg noodles; they also are low in fat and sodium. ...
A sparkling ideaJan 14, 2006 Louisville Courier-Journal, If you keep track of such things, a 240-milliliter serving contains 8 milligrams of sodium and 3 percent of daily recommended calcium. ...
Connie Aclin: Food safety important for moms-to-beJan 13, 2006 Shreveport Times, Serve over rice. Approximate values per 1 cup serving: 274 calories, 8 g fat, 77 mg cholesterol, 30 g protein, 17 g carbohydrates, 187 mg sodium. ...
Rainwater capture can aid with gardening in dry timesJan 14, 2006 Lufkin Daily News, ...for a water softener. Rainwater is also ideal for those on low-sodium diets, since it contains no salt. Plants respond to rainwater ...
Health & Fitness News in BriefJan 14, 2006 Bryan College Station Eagle, Herbs are a healthy substitute for salt if you are watching sodium intake. These will add low-calorie, low-sodium flavor to foods. ...
Newton works to shed light on situationJan 15, 2006 Boston Globe, The city knew about the Walnut Road blackout and ordered high-pressure sodium lamps and other replacement parts on Nov. 21, Solomon said. ...
New sanitizing spray gentleJan 14, 2006 Akron Beacon Journal, The product contains sodium hypochlorite, the same compound used in household bleach but in a much lower concentration that's more akin to pool water. ...
Secrets of the sea Body care Follow-up Healing touchJan 15, 2006 Calcutta Telegraph, ...sea level contains essential minerals like potassium that regulates osmosis and water balance, magnesium that affects cell metabolism, sodium that influences ...
Pet Ecology Brands, Inc. Announces Gross Revenue and Earnings ...Jan 11, 2006 Market Wire (press release) ...launching its fat free cat treats and vitamin enhanced dog treats by the end of March, and also a line of reduced fat and sodium microwavable gourmet cat ...
Salt is salt, despite the typeJan 11, 2006 The Grand Rapids Press, According to the "Food Lover's Companion" by Sharon Tyler Herbst, all salt (sodium chloride) comes either from salt mines or from the sea. ...
Health Alert: Food labelsJan 9, 2006 WIS, ..."I always read the labels because I don't want too much sodium. That's the first thing I look for.". ... And sodium caseinate is a milk protein. ...
Hot and spicy in the freezerJan 12, 2006 Miami Herald, Green Guru's (10 ounces, $3.39) has an acceptable 339 calories and 5 grams of fiber, but 820 milligrams sodium and 18 fat grams. ...
Get with the panJan 11, 2006 Shreveport Times, Approximate values per serving: 803 calories, 40 g fat, 212 mg cholesterol, 33 g protein, 77 g carbohydrate, 4 g fiber, 943 mg sodium. ...
Goodbye Cyanide, Hello Mystery ProcessJan 11, 2006 Boise Weekly, Desert Mineral CEO Dan Terzo told BW his company has long had plans to use sodium bromide rather than cyanide but only recently decided to change course. ...
220 closed at 10 amJan 15, 2006 The Casper Star Tribune, 10 miles west of Casper at mile marker 104, would be closed at approximately 10 am for about four hours while a load of liquified sodium cyanide from a wrecked ...
School hostel food scareJan 5, 2006 Namibian, Namibian warned that the meat products such as mince and sausage supplied to most of Namibia's hostels contained dangerously high levels of sodium (salt) that ...
Injections at SRNH found contaminatedJan 12, 2006 Hindustan Times, ...recently. Three 2 ml viols of dexamethasone sodium phosphate injection have been found containing fungus and dust particles. The ...
Antibiotic Growth Promoters on Their Way OutJan 12, 2006 PR Newswire (press release), The last four antibiotics currently being used as growth promoters - flavophospholipol, monensin sodium, salinomycin sodium and avilamycin - will be completely ...
Rt. 220 closed near Casper following deadly crashJan 12, 2006 Billings Gazette, CASPER -- A crash involving a pickup truck and a tanker truck carrying toxic liquid sodium cyanide killed one person and closed Wyoming 220 south of here. ...
PR Pharmaceuticals (PRP) Announces Collaboration With OSI ...Jan 11, 2006 PR Newswire (press release), ...agreement with OSI Pharmaceuticals to collaborate on the development of a sustained release formulation of Macugen(R) (pegaptanib sodium injection), a novel ...
FDA Approves Astellas' Vaprisol® For Treatment Of Euvolemic ...Jan 1, 2006 Medical News Today (press release), ...indicated for the treatment of euvolemic hyponatremia, a potentially life-threatening condition that occurs when the body's blood sodium level falls ...
Ministry to investigate hostel foodJan 8, 2006 Namibian, ...on Friday exposed how the Catering Association of Namibia (CAN) and its seven member companies were using seaweed-derived products, namely sodium alginate and ...
The X-pert Files: James WatsonJan 3, 2006 New Zealand Herald, It outlines how farmers of the era raced to embrace sodium chlorate as a ragwort killer. Unfortunately, when mixed with the cotton ...
A" Means "One-and-Only-OneJan 5, 2006 Mondaq News Alerts, ...calcium source and at least one phosphoric acid source free of uncombined water as dry ingredients; and a solution consisting of water and a sodium phosphate ...
Watershed council focuses on winter's de-icers as chlorine sourceJan 11, 2006 Gaylord Herald Times, Although sodium chloride is an inexpensive and effective choice, concerns are frequently raised about its potential negative impacts, particularly from chloride ...
ACE Inhibitors Slow Progression of Chronic Renal DiseaseJan 11, 2006 MedPage Today, ...the recommended salt intake (documented by periodic 24-hour urine testing) is approximately 90 to 120 meq per day (approximately 2 to 3 g of sodium per day). ...
Soup is an easy and inexpensive mealJan 11, 2006 Hagerstown Morning Herald, Soup is a tasty way to eat lots of healthy vegetables and beans and you can control the sodium and fat content. Watching your weight? Soups can help. ...
Label LingoJan 2, 2006 Winnipeg Free Press (subscription), Under the rules, labels must state the number of calories, the amount of total fat, saturated and trans fats, cholesterol, sodium, carbohydrate, fibre, sugars ...
Penwest Announces Results of Phase IIa Trial for PW2132Dec 20, 2005 PR Newswire (press release), ...- Torsemide ER Indicates Better Sodium Excretion in Congestive Heart Failure Patients Than Immediate Release Product - DANBURY, Conn., Dec. ...
ISTA Pharmaceuticals Announces Acceptance of ISTA's European ...Jan 12, 2006 PR Newswire (press release), Vitragan is ISTA's proprietary formulation of highly purified ovine hyaluronidase which is commonly known in the US as Vitrase(R). A vitreous hemorrhage occurs ...
ISTA's eye treatment under EU reviewJan 12, 2006 Pharmaceutical Business Review 12 Jan 2006, 17:44 GMT - Vitragan is ISTA's proprietary formulation of highly purified ovine hyaluronidase, which is commonly known in the US as vitrase. ...
pSivida Completes Acquisition of Control Delivery SystemsJan 3, 2006 Business Wire (press release), ...pSivida now owns the only two FDA approved sustained release drug delivery systems for the back of the eye, being Vitrasert(TM)and Retisert(TM). ...
pSivida completes acquisition of US drug delivery firmJan 6, 2006 In-PharmaTechnologist.com, ...now also owns the only two Food and Drug Administration (FDA) approved sustained release drug delivery systems for the back of the eye, Vitrasert and Retisert. ...
