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Gallamine Triethiodide
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DRUG INFO
Gallamine Triethiodide
Drug Name:
Gallamine Triethiodide
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Indication: For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Pharmacology: Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.
Mechanism Of Action: It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.
Drug Category: Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Skeletal Muscle Relaxants; ATC:M03AC02
Brand Names/Synonyms: 3697 R.P.; Benzcurine Iodide; Benzkurin; CHEMBANK1257; F 2559; Flacedil; Flaxedil; Fourneau 2559; G104; Gallaflex; Gallamin; Gallamin Triethiodide; Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triethiodide; Gallamine Triiodoethylate; Gallamine-3eti; Gallamone Triethiodide; Gallamonum; HL 8583; Miowas G; Parexyl; Pirolakson; Pyrolaxon; RP 3697; Relaxan; Remyolan; Retensin; Sincurarine; Syncurarine; Tricuran; Triiodoethylate de Gallamine
Dosage Forms: LIQUID
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: N-[2-[2,3-bis(2-diethylaminoethoxy)phenoxy]ethyl]-N-ethyl-ethanamine
Chemical Formula: C24H45N3O3
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00712
CAS Registry Number: 65-29-2
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