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Foscarnet
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DRUG INFO
Foscarnet
Drug Name:
Foscarnet
Indication: For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Pharmacology: Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarnet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.
Mechanism Of Action: Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.
Drug Category: Antivirals; Reverse Transcriptase Inhibitors; ATC:J05AD01
Brand Names/Synonyms: Carboxyphosphonic Acid; Dihydroxyphosphinecarboxylic Acid Oxide; FOSCARNET; FOSCARNET SODIUM; Formic Acid, Phosphono-; Forscarnet Sodium; Foscarmet; Foscarnet; Foscarnet Sodium; Foscavir; PFA; Phgosphonocarboxylic Acid; Phosphonoformate; Phosphonoformic Acid; Triapten
Dosage Forms: INJECTION
Absorption: Poorly absorbed after oral administration (bioavailability from 12 to 22%).
Interactions:
DrugBank: Interactions for Foscarnet
Interactions for Foscarnet:
A possible drug interaction of FOSCAVIR and intravenous pentamidine has been described. Concomitant
treatment of four patients in the United Kingdom with FOSCAVIR and intravenous pentamidine may have caused
hypocalcemia; one patient died with severe hypocalcemia. Toxicity associated with concomitant use of aerosolized
pentamidine has not been reported.
Because of foscarnet's tendency to cause renal impairment, the use of FOSCAVIR should be avoided in combination
with potentially nephrotoxic drugs such as aminoglycosides, amphotericin B and intravenous pentamidine unless the
potential benefits outweigh the risks to the patient.
Abnormal renal function has been observed in clinical practice during the use of FASCAVIR and ritonavir, or
FOSCAVIR, ritonavir, and saquinavir.
Since FOSCAVIR decreases serum concentrations of ionized calcium, concurrent treatment with other drugs known to
influence serum calcium concentrations should be used with particular caution.
Ganciclovir The pharmacokinetics of foscarnet and ganciclovir were not altered in 13 patients receiving
either concomitant therapy or daily alternating therapy for maintenance of CMV disease.
Chemical IUPAC Name: phosphonomethanoicacid
Chemical Formula: CH3O5P
Half Life: 3.3 to 6.8 hours
Drug Type: Approved Drug
# Accession No: APRD00669
CAS Registry Number: 63585-09-1
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Foscarnet News
(When available)
Formic acid makes airport runways safe for winter take-offs and ... Dec 29, 2005
WebWire (press release), So that planes can take off and land safely airports spray de-icing agents containing formic acid salts on runways, so-called formiates. ...
Making Connections-Tekion "Formira" fuel cells using Colder ... Jan 10, 2006
Fuel Cell Works The Formira fuel cell uses formic acid instead of the usual methane as an H2 agent chiefly because of its higher power density, Man explains. ...
A Cautionary Tale Jan 12, 2006
Philadelphia Inquirer, ...chemical name for NutraSweet, which is found in Jell-O and a whole host of other "sugarless" products, can degrade to methanol, formic acid and formaldehyde ...
Viaspace Subsidiary Direct Methanol Fuel Cell Corporation to Begin ... Jan 11, 2006
Fuel Cell Today, ...larger ones. DMFCC also plans to develop cartridges for other fuels such as formic acid or ethanol, as customers require. DMFCC ...
IRSG announces BASF, IRCo, AFE join panel of Associates Dec 15, 2005
European Rubber Journal (subscription), In a statement announcing BASF's membership, the IRSG said, "It is specifically the manufacturing, marketing and sales of Formic Acid to the Rubber Industry ...
That drinking feeling Dec 12, 2005
Scotsman, ...bloodstream and transported to your liver, which begins to break down the alcohol (ethanol) into substances which include methanol, acetaldehyde and formic acid ...
Understanding the chemistry of a cup of kindness. Dec 29, 2005
Advertiser Adelaide, But it is methanol, ethanol's evil cousin, which does the damage. It's found in many drinks. And your liver turns it into formic acid. Ant sting! ...
Thinking green is a grave undertaking Dec 30, 2005
Yorkshire Post Today, ...country. remain unembalmed instead of being treated with formaldehyde, which oxidises into formic acid and makes the soil toxic. ...
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