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Flupenthixol
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DRUG INFO
Flupenthixol
Drug Name:
Flupenthixol
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Indication: For use in schizophrenia and depression
Pharmacology: Flupenthixol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood.
Mechanism Of Action: Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.
Drug Category: Antipsychotics; Thioxanthenes; Dopamine Antagonists
Brand Names/Synonyms: Depixol; Emergil; FLUPENTHIXOL; Fluanxol; Fluanxol Depot; Flupenthixol; Flupenthixole; Flupentixol; Flurentixol; Fluxanxol; Siplaril; Siplarol
Dosage Forms: TABLET; IM Injection
Absorption: Fairly slow and incomplete after oral administration
Interactions: Drug Interactions:
Flupenthixol may interact with some drugs, like:
- Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics
- Arecoline
- Eproxindine
- Ethanol: Flupenthixol and Ethanol cause additive CNS depression
- Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants
Chemical IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
Chemical Formula: C23H25F3N2OS
Half Life: 19 to 39 hours
Drug Type: Approved Drug
# Accession No: APRD00388
CAS Registry Number: 2709-56-0
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