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Fluoxetine
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DRUG INFO
Fluoxetine
Drug Name:
Fluoxetine
Indication: For the treatment of depression; Obsessive compulsive disorder; Bulimia nervosa
Pharmacology: Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Mechanism Of Action: Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Drug Category: Antidepressants, Second-Generation; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB03
Brand Names/Synonyms: Animex-On; Deprex; Eufor; Fluctin; Fluoxeren; Fluoxetina [Inn-Spanish]; Fluoxetina [Spanish]; Fluoxetine; Fluoxetine Hcl; Fluoxetine Hydrochloride; Fluoxetine Hydrochloride: Adofen; Fluoxetinum [Inn-Latin]; Fluval; Fontex; Foxetin; HSDB 6633; Portal; Prozac; Prozac Weekly; Pulvules; Reneuron; Sarafem
Dosage Forms: CAPSULE; LIQUID; SOLUTION
Absorption: 72%
Interactions: Do not take this medicine with thioridizine, or within 5 weeks of taking fluoxetine.
Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin
or azithromycin. This medicine should not be taken with MAO inhibitors.
Caution should be exercised when taking this medicine certain antibiotics, such as erythromycin,
clarithromycin, or azithromycin. This medicine should not be taken with MAO inhibitors. If you
think you are taking an MAO inhibitor talk to your doctor or pharmacist. Do not take this medicine
with St. John's Wort because of the additive effects of sertonin.
This medication should not be taken with MAO inhibitors. Your doctor or pharmacist can give you more information
on MAO inhibitors. Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor. Wait 2
weeks after stopping an MAO inhibitor before starting escitalopram.
If you are taking medications for migraines such as Imitrex, talk to your doctor before starting this medicine.
If you are taking a tricyclic antidepressant, talk to your doctor before taking this medicine.
St. JohnˇŻs Wort should be avoided while taking this medicine due to the additive effects of serotonin.
Tell your doctor if you are taking any of the following drugs:
blood thinners (Coumadin)
other antidepressants
metoprolol
antihistamines
carbamazepine (Tegretol)
cimetidine (Tagamet)
estrogens
fluoxetine (Prozac)
intraconazole (Sporanox)
ketoconazole (Nizoral)
levodopa
lithium
muscle relaxants
birth control pills
sleeping pills
thyroid medications
Chemical IUPAC Name: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
Chemical Formula: C17H18F3NO
Half Life: 1 to 3 days
Drug Type: Approved Drug
# Accession No: APRD00530
CAS Registry Number: 54910-89-3
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Fluoxetine News
(When available)
Did Lincoln need Prozac? You might after depressing biopic 16 Jan 2006
Salt Lake Tribune, By David Kronke. Just a theory, but maybe any given portrait of Abraham Lincoln reflects at least as much on the person assembling ...
Ask Dr. H | Old-timey ailments with quaint names 16 Jan 2006
Philadelphia Inquirer, ...or tincture. Before Elavil and Prozac, the herbs skullcap and mugwort were often combined to aid in treating depression. St. Vitus ...
Omnicare subpoenaed in generic drug probe 16 Jan 2006
Louisville Business First, ...heartburn drug Zantac. Giving tablets instead of capsules of Fluoxetine, a generic form of the antidepressant Prozac. Substituting two ...
Drugs and electroconvulsive therapy best treatment for severe ... 16 Jan 2006
News-Medical.net, ...decade, two treatments which are often castigated in the media, and have raised both public and professional concern, antidepressants such as Prozac and Seroxat ...
Doctors, Studies Say Anti-depressants Work 16 Jan 2006
13WHAM-TV, A review in the British Journal Lancet reported that for the most common types of depression, medications like Prozac are still the most effective treatments. ...
MMC Speaker 'Millenials' Plagued By Mental Health Issues 16 Jan 2006
Yankton Daily Press, ...years lead to a lot of mental health problems," said South Dakota State University professor Ruth Harper Friday at a presentation titled "Prozac Nation Goes To ...
Antidepressants still the answer despite risks (Australian) 16 Jan 2006
AustralianDoctor.com (subscription), A new review of evidence by Scottish doctors in the Lancet says drugs such as Prozac and electroconvulsive therapy remain the most effective treatments for all ...
It's a SAD season : When gloomy mood matches the weather, begin ... 16 Jan 2006
Jackson Sun, Antidepressants like Prozac work in 50 percent to 60 percent of people, and light therapy is effective in as many as 70 percent of patients, says Dr. Alireza ...
When you're feeling SAD 16 Jan 2006
The News Journal, Antidepressants like Prozac are the main choice for people who want a quick, convenient option and whose insurance does not pay for light units or counseling ...
Prozac counters emotional turmoil after stroke Jan 13, 2006
Reuters NEW YORK (Reuters Health) - The antidepressant Prozac (fluoxetine) may help relieve certain emotional disturbances in patients who've suffered a stroke, Korean ...
DOCS DEBUNK SUICIDE RISK OF PROZAC Jan 9, 2006
New York Post, The study also linked Prozac and other selective serotonin re-uptake inhibitors with a faster decline in the rate of suicidal behavior than older drugs.
Joe Hart: If Favre retires, better pass the Prozac Jan 2, 2006
The Capital Times, ...surrounding this franchise, and with many pink slips soon to be delivered, the only issue fans truly care about is this: Will there be enough Prozac to go ...
Antidepressants (Eli Lilly & Co.'s Prozac) don't cause suicide ... Jan 3, 2006
EnjoyFrance.com, Antidepressants such as Eli Lilly & Co.'s Prozac don't appear to cause a higher risk of suicide by those taking them in the six months after they're prescribed ...
Prozac in motion Jan 5, 2006
Ha'aretz (subscription), 1 user of Prozac in the country. It was 15 years ago. ... After she finished laughing at my ignorance, she said: "So maybe if you take Prozac you'll finally write. ...
'Prozac Nation' Presentation Set For MMC Jan 6, 2006
Yankton Daily Press, The Mount Marty College Enrollment Management Committee is sponsoring a presentation by Ruth Harper, entitled "Prozac Nation: The Mental Health Issues of ...
eet Larry King on Prozac Dec 28, 2005
National Review Online, So while Russert wouldn't devote a whole show to nothing but softball questions for a politician or CEO, he turns into Larry King on Prozac when interviewing ...
Tough times for Prozac Democrats Dec 21, 2005
Washington Times, ...major stress factor. If I were a liberal who derived my primary hope from government, I'd be ready for some Prozac, too. And herein ...
Antidepressants still the answer despite 'risks' Jan 15, 2006
Australian, But a new review of evidence by Scottish doctors says drugs such as Prozac and electroconvulsive therapy remain the most effective treatments for all but ...
Electric shock and drugs 'are best hope for depressives' Jan 13, 2006
Times Online, TWO treatments that have been castigated in the media, electroconvulsive therapy (ECT) and antidepressants such as Prozac and Seroxat, remain the best hope for ...
Through the Times With Peter Kramer, MD Jan 12, 2006
Psychiatric Times, Indirectly, the "Practicing" column also led to the publication of Kramer's bestseller Listening to Prozac (New York: Viking, 1993; second edition, Penguin ...
FDA Warns Against Two Brazilian Diet Pills Jan 13, 2006
All Headline News Associated Press. The are advertised as all-natural, but they may contain controlled substances like Librium and Prozac. These can ...
FDA warns consumers to avoid Brazilian diet pills Jan 13, 2006
KTVO, The agency says they're billed as all-natural but may contain active ingredients normally found only in prescription drugs like Librium and Prozac. ...
Ask Dr. H Jan 13, 2006
Fort Wayne News Sentinel, ...tincture. Before Elavil and Prozac, the herbs skullcap and mugwort were often combined to aid in the treatment of depression. St. ...
Doctor calls Demeniuk 'controlling' Jan 14, 2006
St. Augustine Record, The section dealt with a young man who was taking Prozac, another SSRI. "Prozac would be out of the question," Kirwin wrote. "It ...
Sadness, Gladness—and Serotonin Jan 1, 2006
Commentary, Against Depression, 1 Peter D. Kramer, a clinical professor at Brown University, has written a kind of sequel to his pathbreaking Listening to Prozac of twelve ...
FDA Warns Consumers on Brazilian Diet Pills Jan 13, 2006
ABC News ...are billed as all-natural but may contain active ingredients, including controlled substances, normally found only in prescription drugs like Librium and Prozac ...
Making Peace with My Emotions Jan 11, 2006
ChristianityToday.com, She suggested a prescription antidepressant, such as Prozac, about which I'd need to speak to my medical doctor. ... The Prozac was working! ...
When the Blues go bad Jan 11, 2006
Utah Statesman (subscription), According to a study conducted in June of 2001 by Express Scripts, a pharmacy benefit management firm, more Utahns take Prozac-style drugs than any other state ...
Levy scores one for older folks Jan 15, 2006
Buffalo News, Just because you're beyond 75 doesn't mean you're ready for the scrap heap. Bills owner Ralph Wilson cracks Prozac jokes at 87. ...
"What questions have disappeared?" Jan 15, 2006
The Common Voice, Prefer "The Matrix" or "You've Got Mail'? Eminem or Sophie B. Hawkins? Been to Ibiza or Cool Britannia? Taking Prozac or Wellbutrin for the depression? ...
Woman Loses Custody of Children to County Jan 10, 2006
WNEP-TV, Then there's 80 milligrams of Prozac, legally I don't think I could sign anything legally being on all these crazy pills for depression and anxiety," Baggett ...
Even Hamsters Get the Blues, Scientists Find Jan 10, 2006
WZZM, ...less and appeared more anxious. The study is continuing, with lab assistants trying to treat the depressed hamsters with Prozac.
Thoughts for 2006 Jan 9, 2006
Electric New Paper, ...cents? People used to take acid to make the world weird. Now the world is weird and people take Prozac to make it normal. Maybe ...
Mental health topic of Mount Marty presentation Jan 12, 2006
Sioux Falls Argus Leader, The college's Enrollment Management Committee is sponsor of the presentation, "Prozac Nation: The Mental Health Issues of Today's College Students," by Ruth ...
Does Abortion Impact the Mental Health of Women? Jan 15, 2006
Scoop.co.nz (press release), If this were Prozac or Vioxx, reports of associated harm would be taken much more seriously with more careful research and monitoring procedures.". ...
TeenScreen - New York Times - Danger Signs Dec 17, 2005
OpEdNews The truth is that in 1987, Prozac, the first in a stream of SSRI antidepressants, hit the market which necessitated a heavy-duty plan for legal drug pushing. ...
Depression Drugs Safe, Beneficial, Studies Say Dec 31, 2005
Washington Post, Antidepressants, such as Prozac and similar drugs, help many patients overcome their often disabling psychiatric disease and do not increase the risk for ...
Antidepressants Don't Appear to Raise Suicide Risk, Study Shows Jan 1, 2006
Bloomberg 1 (Bloomberg) -- Antidepressants such as Wyeth's Effexor and Eli Lilly & Co.'s Prozac don't appear to pose a higher risk of suicide in the six months after they ...
Studies find antidepressants safe Jan 2, 2006
Newsday, WASHINGTON - Antidepressants such as Prozac and similar drugs help many patients overcome disabling psychiatric disease and do not increase the risk for suicide ...
Antidepressants don't raise risk of suicide, studies say Jan 1, 2006
Indianapolis Star, WASHINGTON -- Antidepressants, such as Indianapolis-based Eli Lilly's Prozac and similar drugs, help many patients overcome their often disabling psychiatric ...
Insanity Plea Considered in Sex Attack Case Jan 5, 2006
New York Times, Mr. Braunstein's mother, Angele, told The New York Sun in November that her son had been taking Prozac to treat depression. She ...
Cameron exploits his disabled son, says Hewitt Jan 7, 2006
Independent, She hinted at a huge expansion of counsellors and therapists who will take the place of Prozac and other anti-depressant medication. ...
Studies Back Antidepressants Jan 1, 2006
Hartford Courant, WASHINGTON -- Antidepressants, such as Prozac and similar drugs, help many patients overcome their often disabling psychiatric disease and do not increase the ...
Study counters past data linking antidepressants to increased ... Jan 1, 2006
Baltimore Sun, The controversy has raged since the 1980s when critics alleged that Prozac, the first in a new class of medications, prompted some adults to commit violence ...
Antidepressants do not encourage suicidal tendencies: Study Jan 8, 2006
What is the Word, Around 122 million prescriptions were written for drugs such as Prozac in America last year. The current study also said that the ...
Update 1-Omnicare says gets subpoena from US Attorney Jan 13, 2006
Reuters ...drug Zantac; tablets for capsules of Fluoxetine, the generic version of Eli Lilly and Co's (LLY.N: Quote, Profile, Research) antidepressant Prozac; and the ...
Ruth Wajnryb: A daring word collector finds endless rewards Jan 13, 2006
Sydney Morning Herald, ...friends. "Gloom" and cousin "glumness" are far heavier round the shoulders. Gloom and glumness might need a kick-start of Prozac. Life ...
The fool's gold that heals Jan 13, 2006
Guardian Unlimited, In clinical trials for depression, people taking Prozac improved on average by 8.3 percentage points on a standard scale that quantifies the severity of the ...
The Agony and the Ecstasy Jan 4, 2006
New City Chicago, ..."Shit! Prozac!" I remembered and reached for an orange bottle, popped a couple into my mouth and swallowed them down with a gulp of wine. ...
FDA warns 2 Brazilian diet pills contain amphetamines Jan 13, 2006
WTOP, ...the FDA confirmed on Friday the pills contain a type of amphetamine as well as tranquilizers (the generic for Librium) and antidepressants (generic Prozac). ...
Change of plea is anticipated Jan 13, 2006
The Republican, He said he was currently taking Prozac, an anti-depressant drug. "I am not confused at all," Dubuc told Rup. "I'm doing this of my free will.".
Studies: antidepressants are effective, don't add suicide risk Jan 1, 2006
philly.com, 2 large projects on drugs such as Prozac prompted some to call on the FDA to rethink its warnings. By Rob Stein and Marc Kaufman. ...
Only the lonely Jan 14, 2006
Austin American-Statesman (subscription), ...the kind of ironic self-pity that marks the slacker novel, and, despite suffering from depression so radiant that they could star in Prozac commercials, they ...
Obsession on looks breeds shallowness Jan 12, 2006
Dallas Voice, ...(Of course, this is the same movie that interviews Dr. Jeffrey Satinover, a quack that says Prozac may “cure� homosexuals.) In vivid detail, the film shows ...
Another eyesore bites the dust Jan 13, 2006
Portland Tribune, I looked around the house and finished off a bottle of merlot, a bottle of white zinfandel, a bottle of Kahlua, the remainder of my old Prozac prescription, a ...
Protein Linked to Depression Jan 5, 2006
Forbes A target of the antidepressants called selective serotonin reuptake inhibitors (SSRIs), which include Prozac, serotonin has been linked to depression and ...
A New Year's Top 10 list for the left Jan 1, 2006
Globe and Mail, By JIM STANFORD. As a die-hard socialist living in pretty capitalistic times, I take a good shot of left-wing Prozac with my orange juice every morning. ...
Sometimes, you let leaping dogs fly Jan 8, 2006
Boston Globe, Years of pleading with her to behave never worked. Nor did the Prozac the vet prescribed. Only old age slowed her down. And only death stopped her. ...
Antidepressants don't add to suicide risk, studies say Jan 1, 2006
Austin American-Statesman (subscription), WASHINGTON — Antidepressants, such as Prozac and similar drugs, help many adult and teen patients overcome their often disabling psychiatric diseases and do ...
Shakeup brings team into a new golden age Jan 6, 2006
Rochester Democrat and Chronicle, ...(January 6, 2006) — ORCHARD PARK — Ralph Wilson told the media he had to up his Prozac dosage because this season had been so depressing. ...
Today's top stories Jan 1, 2006
Arizona Republic, New findings on drugs, suicide: Antidepressants, such as Prozac, help many patients overcome their often debilitating psychiatric disease and do not increase ...
Discovery could lead to new treatments for depression Jan 5, 2006
St. Petersburg Times, Most depression medications used today are members of the Prozac family that work by making more serotonin available to brain cells. ...
Every now and then, we win a battle or two Jan 3, 2006
Rabble.ca, As a die-hard socialist living in pretty capitalistic times, I take a good shot of left-wing Prozac with my orange juice every morning. ...
Buffalo Bills Insider Jan 6, 2006
Buffalo Bills Insider, Democrat & Chronicle: Ralph Wilson told the media he had to up his Prozac dosage because this season had been so depressing. The ...
A New Year’s Resolution Jan 4, 2006
PR Web (press release), Although medications such as Effexor, Prozac, Paxil, Wellbutrin, Zoloft and Celexa are considered non-addictive, there are many people who describe vast swings ...
Antidepressants Don’t Increase Suicide Risk Jan 3, 2006
Christian Broadcasting Network, But new government-sponsored studies on some of the most popular antidepressants, such as Prozac, Zoloft, Celexa, and others, such as Paxil, Lexapro, Effexor ...
Messengers of the Brain Jan 1, 2006
About - News & Issues, You're taking Prozac, and you've heard it described as an SSRI. Maybe you know that SSRI stands for Selective Serotonin Reuptake Inhibitor. ...
Diary - William Leith Jan 5, 2006
New Statesman, We are a nation of shopaholics, and we have become like those alcoholics who think that the wine bottles are getting smaller. My advice: buy shares in Prozac. ...
Applying the Benedictine rule Jan 4, 2006
Stuff.co.nz, ...died of thirst. The barman was incompetent. He dished out drinks with all the vigour of a sloth on Prozac. And he approached the ...
BOOKS: Frey’s Memoirs Join Others Whose Veracity is in Dispute Jan 12, 2006
HNN Huntingtonnews.net, Lauren Slater, whose first book was an account of her depression, "The Prozac Diaries," followed with "Lying: A Metaphorical Memoir" in which she admitted that ...
Flashback: Frey's Incredible Suffering Not So Credible Jan 10, 2006
Village Voice, It could be given a room next to Infinite Jest, or sneak out to meet Prozac Nation in the woods. Actually, there is such a place. It’s called editing.
SSRIs Boost Brain Growth, Hopkins Scientists Report Dec 24, 2005
Medical News Today (press release), Antidepressants, such as Prozac, Zoloft and Paxil, have long been thought to exert their clinical effects by increasing synaptic concentrations of serotonin ...
Antidepressants May Boost Brain Growth Dec 28, 2005
WebMD One was Prozac, an SSRI drug that increases serotonin. ... Despite their different actions, both Prozac and tianeptine made the rats' brains more dense. ...
In these SAD times of the year, follow the sun Jan 11, 2006
USA Today Antidepressants such as Prozac work in 50% to 60% of people, and light therapy is effective in as many as 70% of patients, says Alireza Amirsadri, a ...
Acne medication can cause depression Jan 10, 2006
Newsday, Of these, 72 were linked to Accutane. The next highest number of drug-linked suicides in that period - 55 - involved Prozac (fluoxetine). ...
Gray Matters Dec 31, 2005
Entrepreneur ...advantages. By now, everybody's heard of the antidepressant Prozac and other new drugs and supplements that tinker with brain workings. ...
Therapies offer hope for SAD sufferers Jan 10, 2006
Wilkes Barre Times-Leader, Anti-depressants such as Prozac work in 50 percent to 60 percent of people, and light therapy is effective in as many as 70 percent of patients, says Dr ...
Financial Relations Board Names Scott Eckstein as Director for ... Jan 9, 2006
Market Wire (press release) Eckstein also provided counsel on corporate re-branding for Eli Lilly in advance of the patent expiration of Prozac; coordinated Cendant Corporation's outreach ...
TeenScreen's Pseudo-Scientific Basis Jan 6, 2006
SierraTimes.com ...all of its diagnoses are merely syndromes [or disorders], clusters of symptoms presumed to be related, not diseases.� – from Prozac Backlash: Overcoming ...
Natural approaches for psychological disorders Jan 10, 2006
The South African Journal of Natural Medicine (subscription), Instead of blocking serotonin as many drugs such as Prozac do, the practitioner can use one of these amino acids to increase serotonin production by increasing ...
Deep Thoughts Revealed: Inside the Minds at the Alito Confirmation ... Jan 12, 2006
DeadBrain.us (satire) ...loose bowels. And I mean, for Christ’s sake, she’s got the personality of Laura Bush before her morning dose of Prozac. Just ...
Light, dark and hamster happiness Jan 10, 2006
Columbus Dispatch, And the research isn’t ready to be applied to humans just yet. The next step: Student lab assistants are trying to treat the depressed hamsters with Prozac. ...
Genes’ influence on common drugs may affect health-care quality ... Jan 9, 2006
innovations report, Among these drugs are fluoxetine (Prozac™), metoprolol (a beta-blocker), diltiazem (used to treat high blood pressure), and warfarin (an anticoagulant). ...
Natural Remedies Blow Colds Away Jan 10, 2006
Open PR (press release), In Germany, where it's currently the leading treatment, physicians write some three million prescriptions a year-25 times the number they write for Prozac.". ...
CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment Jan 12, 2006
Psychiatric Times, ...evaluated the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine (Prozac), cognitive-behavioral ...
Atomic Hangover Jan 12, 2006
North Bay Bohemian, Prozac was there to help the transition, but the best elixir seemed to be the Glasnost promise of the Internet, at least for those of us who sold out before ...
Stem-Cell Researcher Hwang to Quit Over Faked Study (Update3) Dec 23, 2005
Bloomberg Michael Hunt, the chief executive officer of ReNeuron Group Plc, a UK stem cell research company, said Hwang's research may hurt the public's view of the ...
Good counsel: Premenstrual disorders Dec 22, 2005
Rochester Democrat and Chronicle, Medications have been found to be helpful. Antidepressants known as SSRIs, such as Sarafem, Zoloft and Paxil, are approved by the FDA to treat this condition. ...
Premenstrual Syndrome Fact Sheet Dec 18, 2005
Community Dispatch (press release) The Food and Drug Administration (FDA) has approved two such medications to date for treatment of PMDD - sertraline (Zoloft) and fluoxetine (Sarafem).
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