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Fluorouracil
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DRUG INFO
Fluorouracil
Drug Name:
Fluorouracil
Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
Pharmacology: Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
Mechanism Of Action: Fluorouracil inhibits thymidylate synthetase, leading to inhibition of DNA and RNA synthesis and cell death.
Drug Category: Immunosuppressive Agents; Antimetabolites; Antimetabolites; Antineoplastic Agents; ATC:L01BC02
Brand Names/Synonyms: 5 Fluorouracil; Adrucil; Arumel; Carac; Carzonal; Effluderm; Efudex; Efudix; Efurix; FT-207; FU; Fluoroblastin; Fluoroplex; Fluorouracil; Fluracil; Fluracilum; Fluri; Fluril; Fluro Uracil; Ftoruracil; Kecimeton; NSC 19893; NSC-19893; Phthoruracil; Phtoruracil; Queroplex; Timazin; U 8953; U-8953; URF; Ulup
Dosage Forms: Topical preparations, Solution for injection
Absorption: 28-100%
Interactions:
DrugBank: Interactions for Fluorouracil
Interactions for Fluorouracil:
No information available.
Chemical IUPAC Name: 5-fluoro-1H-pyrimidine-2,4-dione
Chemical Formula: C4H3FN2O2
Half Life: 10-20 minutes
Drug Type: Approved Drug
# Accession No: APRD00516
CAS Registry Number: 51-21-8
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Fluorouracil News
(When available)
PETA , Rising Coal Prices Are Grounding Santa‘s Sleigh Dec 18, 2005
Halifax Live, 1) Due to new regulations passed by the Canadian Aviation Regulation Advisory Council (CARAC), all transports that rely solely on reindeer or similar species ...
GOUT COMES FROM URIC ACID CRYSTALS IN JOINTS Dec 19, 2005
Charlotte Sun-Herald, Another treatment is fluorouracil cream, which is self-applied. Treatment continues for two to four weeks. Two brand names are Efudex and Fluoroplex. DEAR DR. ...
GOUT COMES FROM URIC ACID CRYSTALS IN JOINTS Dec 19, 2005
Charlotte Sun-Herald, Another treatment is fluorouracil cream, which is self-applied. Treatment continues for two to four weeks. Two brand names are Efudex and Fluoroplex. DEAR DR. ...
Ankara hosts TESEV symposium on ‘Democratizing Security and the ... Dec 17, 2005
Turkish Daily News (subscription), While State Minister Atalay delivered a keynote speech, DCAF Deputy Director Dr. Philipp Fluri also made a presentation on the topic of “Media, Security and ...
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