Indication: For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Mechanism Of Action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Drug Category: Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents; ATC:L01BB05
Dosage Forms: TABLET; POWDER FOR SOLUTION; IV Solution
Absorption: Not Available
Interactions:
DrugBank: Interactions for Fludarabine
Interactions for Fludarabine:
The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe
pulmonary toxicity.
Chemical IUPAC Name: [5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid
Chemical Formula: C10H13FN5O7P
Half Life: 20 hours
Drug Type: Approved Drug
# Accession No: APRD00594
CAS Registry Number: 75607-67-9
Fludarabine News (When available)
New Study Reinforces Increased Life Expectancy with MabCampath(R) ...Dec 13, 2005 PR Newswire UK (press release), ...antibody approved for CLL and the first drug with proven efficacy in CLL patients who have failed both alkylating agents and Fludara (fludarabine phosphate ...
New Study Reinforces Increased Life Expectancy with MabCampath(R) ...Dec 13, 2005 PR Newswire UK (press release), ...approved for CLL and the first drug with proven efficacy in CLL patients who have failed both alkylating agents and Fludara (fludarabine phosphate) treatment. ...
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