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Flucloxacillin
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DRUG INFO
Flucloxacillin
Drug Name:
Flucloxacillin
Indication: For bacterial infection
Pharmacology: Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through Flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Flucloxacillin interferes with an autolysin inhibitor.
Drug Category: Anti-bacterial Agents; Penicillins; ATC:J01CF05
Brand Names/Synonyms: BRL 2039; FLOXACILLIN; Floxacillin; Floxacillin [Usan]; Floxapen; Fluclox; Flucloxacilina [Inn-Spanish]; Flucloxacillin; Flucloxacillin Sodium; Flucloxacillin-Sodium; Flucloxacilline [Inn-French]; Flucloxacillinum [Inn-Latin]; Sesamol
Dosage Forms: LIQUID
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 7-[3-(2-chloro-6-fluoro-phenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid
Chemical Formula: C19H17ClFN3O5S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00609
CAS Registry Number: 5250-39-5
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Flucloxacillin News
(When available)
Police arrest man over medicine theft Dec 28, 2005
The Nation, Malawi, Some of the drugs alleged to have been found with Manda are Chloramphenicol Sodium, Ampicillin Sodium, Flucloxacillin Sodium, Amoxilin capsules and TB drugs. ...
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