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Floxuridine
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DRUG INFO
Floxuridine
Drug Name:
Floxuridine
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Indication: For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
Pharmacology: Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
Mechanism Of Action: Floxuridine is rapidly catabolized to 5-fluorouracil which is the active form of the drug. Fluorouracil inhibits thymydilate synthase leading to inhibition of DNA synthesis, RNA synthesis and cell death.
Drug Category: Antivirals; Antimetabolites
Brand Names/Synonyms: 5 Fluorodeoxyuridine; 5fdu; Deoxyfluorouridine; FDUR; FUDR; Fdurd; Floxiridina [Inn-Spanish]; Floxuridin; Floxuridine; Floxuridine [Usan:Inn]; Floxuridinum [Inn-Latin]; Fluorodeoxyuridine; Fluoruridine Deoxyribose; HSDB 3227; NSC 27640; NSC-26740; NSC-27640
Dosage Forms: POWDER FOR SOLUTION (500mg vial)
Absorption: Not Available
Interactions: Interactions for Floxuridine:
Combination Therapy: Any form of therapy which adds to the stress of the patient, interferes with nutrition or depresses bone marrow function will increase the toxicity of Floxuridine.
Chemical IUPAC Name: 5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione
Chemical Formula: C9H11FN2O5
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00692
CAS Registry Number: 50-91-9
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