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Filgrastim
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DRUG INFO
Filgrastim
Drug Name:
Filgrastim
Indication: Increases leukocyte production, for treatment in non-myeloid cancer,neutropenia and bone marrow transplant
Pharmacology: Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.
Mechanism Of Action: Filgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase
Drug Category: Immunomodulatory Agents; Anti-infective Agents; Antineutropenic Agents; hematopoietic agents (20:16.00)
Brand Names/Synonyms: Granulocyte colony-stimulating factor precursor;G-CSF;Pluripoietin;Filgrastim;Lenograstim; Neupogen (Amgen Inc.)
Dosage Forms: SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human granulocyte colony stimulating factor
Chemical Formula: C845H1343N223O243S9
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00072
CAS Registry Number: 143011-72-7
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Filgrastim News
(When available)
Autologous Stem Cell Transplants: Less Toxic Consolidation Therapy ... Jan 10, 2006
Cancer Consultants (press release), ...daunomycin. Autologous peripheral blood stem cells were harvested after cytarabine, daunomycin and Neupogen® (filgrastim). Table ...
Superiority of Alkeran®, Thalidomid® Prednisone Regimen for ... Jan 5, 2006
Cancer Consultants (press release), ...or a regimen of VAD (vincristine, doxorubicin, dexamethasone) followed by mobilization of stem cells with cyclophosphamide and Neupogen® (filgrastim) and ...
Drug duo: New hope in cancer fight Dec 18, 2005
Macon Telegraph, ...again. Doctors have routinely given transplant patients a drug called Neupogen to coax the bone marrow to produce more stem cells. ...
CSI: Your Portfolio Jan 4, 2006
Motley Fool I'm that guy. The biotech giant behind Epogen and Neupogen was one of the better performing stocks of that decade, but you wouldn't know it from my account. ...
Abraxane™ Safe When Used in Dose-Dense Therapy Regimen for ... Dec 19, 2005
Cancer Consultants (press release), Twenty-seven out of 29 patients were able to receive Abraxane, with one-third of these patients receiving Neupogen® (filgrastim). ...
Thalidomide Improves Initial—not Overall—Response Rate in ... Dec 29, 2005
Cancer Consultants (press release), ...assigned to receive three cycles of VAD versus three cycles of TAD, followed by CAD (cyclophosphamide, doxorubicin, and dexamethasone) with Neupogen® for the ...
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