Indication: For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.
Pharmacology: Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
Mechanism Of Action: Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
Drug Category: Serotonin reuptake inhibitor; Anorexigenic Agents; Stimulants; ATC:A08AA02; ATC:A08AA04
Interactions:
DrugBank: Interactions for Fenfluramine
Interactions for Fenfluramine:
Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa,
reserpine.
Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be
additive.
Chemical IUPAC Name: N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine
Chemical Formula: C12H16F3N
Half Life: 20 hours
Drug Type: Approved Drug
# Accession No: APRD00319
CAS Registry Number: 458-24-2
Fenfluramine News (When available)
'I don't want this in my life'Jan 13, 2006 Joplin Globe, ...school counselor from Webb City, is suing the pharmaceuticals company Wyeth for alleged damage to her heart valves caused by the diet drugs Pondimin and Redux. ...
Wyeth 2006 forecast misses Street viewsJan 9, 2006 San Jose Mercury News, ...restructuring the sales staff to increase productivity and progress in resolving the eight-year litigation over Wyeth's withdrawn diet drugs, Pondimin and Redux ...
Pa. Appeals Court Backs Duty to Warn RulingDec 28, 2005 Texas Lawyer (subscription), She alleged that taking the diet drugs Pondimin and Redux caused her heart valves to leak and that Wyeth failed to provide an adequate warning about the ...
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