Indication: For use as a female contraceptive (depot)
Pharmacology: Etonogestrel is used as a female contraceptive. Etonogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Etonogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Mechanism Of Action: Etonogestrel binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like etonogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
Interactions:
DrugBank: Interactions for Etonogestrel
Interactions for Etonogestrel:
Etonogestrel may interact with the following medications: acetaminophen
(Tylenol), antibiotics such as ampicillin and tetracycline, anticonvulsants (Dilantin, Phenobarbital, Tegretol,
Trileptal, Topamax, Felbatol), antifungals (Gris-PEG, Nizoral, Sporanox), atorvastatin (Lipitor), clofibrate
(Atromid-S), cyclosporine (Neoral, Sandimmune), HIV drugs classified as protease inhibitors (Agenerase, Crixivan,
Fortovase, Invirase, Kaletra, Norvir, Viracept), morphine (Astramorph, Kadian, MS Contin), phenylbutazone,
prednisolone (Prelone), rifadin (rifampin), St. John's wort, temazepam, theophylline (Theo-Dur), and vitamin C.
Chemical IUPAC Name: 13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Chemical Formula: C22H28O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00766
CAS Registry Number: 54048-10-1
Etonogestrel News (When available)
OR Provider numberJan 10, 2006 AustralianDoctor.com (subscription), By Bianca Nogrady. IMPLANON’S design has been altered to help doctors check the contraceptive implant has been correctly inserted. ...
New pill changes perception of birth controlDec 19, 2005 Hagerstown Morning Herald, A contraceptive product called Implanon is still being researched. Implanon is a single, plastic rod inserted under the skin in the upper arm. ...
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