Indication: For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
Pharmacology: Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprothixene, thiothixene, loxapine, and haloperidol. Unlike other NMDA antagonists, ethopropazine — because of its anticholinergic action — is largely devoid of neurotoxic side effects. Ethopropazine also has a slight antihistaminic and local anesthetic effect.
Mechanism Of Action: Ethopropazine's antiparkinson action can be attributed to its anticholinergic properties. Ethopropazine partially blocks central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity in the basal ganglia; salivation may be decreased, and smooth muscle may be relaxed. Drug-induced extrapyramidal symptoms and those due to parkinsonism may be relieved, but tardive dyskinesia is not alleviated and may be aggravated by anticholinergic effects. Ethopropazine's local anesthetic effect is due to its antagonism of the NMDA glutamate receptor. Glutamate is recognized as an important transmitter in nociceptive pathways, and the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor, in particular, has been implicated in the mediation of neuropathic pain. Excessive release of glutamate at NMDA receptors on dorsal horn neurons of the spinal cord results in hyperactivation and hypersensitivity of these receptors (perceived as hyperalgesia), thought to be an integral feature of neuropathic pain.
Drug Category: Antiparkinson Agents; Antidyskinetics
Absorption: Well-absorbed from the gastrointestinal tract.
Interactions:
DrugBank: Interactions for Ethopropazine
Interactions for Ethopropazine:
Ethopropazine may interact with alcohol or other CNS depressants, causing
increased sedative effects. It may also interact with amantadine or other anticholinergic drugs or MAOIs, which may
intensify the anticholinergic action. Ethopropazine can interact with chlorpromazine, increasing the metabolism of
chlorpromazine.
Chemical IUPAC Name: N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
Chemical Formula: C19H24N2S
Half Life: 1 to 2 hours
Drug Type: Approved Drug
# Accession No: APRD00729
CAS Registry Number: 1094-08-2
Ethopropazine News (When available)
Parkin happy with Tigers switch16 Jan 2006 Football.co.uk, Hull City's new signing Jon Parkin has expressed his joy at his recent transfer to the KC Stadium from League Two side Macclesfield. ...
Imps miss out on unambitious Elding16 Jan 2006 sportnetwork.net, It is the third player that City have missed out on in the transfer window as Jon Parkin joined Hull City and Keith Alexander ruled out paying £50,000 on ...
Relegation ? - Not Going To Happen16 Jan 2006 Vitalfootball, City again shifted things around for the home game with Crystal Palace, including giving debuts to both new strikers Jon Parkin and Daryl Duffy but he saw his ...
PAT: Statement on registration of sex offenders16 Jan 2006 Politics.co.uk, ...suitability of teachers. PAT General Secretary Philip Parkin said: “There needs to be an end to this confusion. There are worrying ...
Early Goals16 Jan 2006 Vitalfootball, ...early enough. 'If we'd have maybe got some diagonal service to Jon Parkin then it would have caused them a few problems. 'So that's ...
Mothers back at school in drive against teenage pregnancies16 Jan 2006 Yorkshire Post Today, In Mexborough the course is run by school nurse Rachel Parkin who is planning to launch a series of courses at the Doncaster Road Junior School. ...
In the Championship – All going worse for CreweJan 15, 2006 Clarets MAD, They were soon two up through Darren Ward and a Leon Cort own goal but Hull immediately responded with a goal from debutant Jon Parkin. ...
Minstermen get Parkin paybackJan 13, 2006 confguide.com, York City are set to receive a welcome financial boost following the news that former striker Jon Parkin has signed for Coca-Cola Championship outfit Hull City ...
Pre-annexation on council agendaJan 14, 2006 The Register-Mail, Community Development Director Roy Parkin said no further changes have been made to the site plan since Maresh's Dec. 20 presentation. ...
Horton waits on Parkin futureJan 10, 2006 Manchester Evening News, BRIAN Horton will not be adding to the squad while Jon Parkin remains at Moss Rose. ... Horton has said he will only be looking for new signings if Parkin moves. ...
City out of Parkin race......for nowJan 9, 2006 sportnetwork.net, By Nathan Jackson - January 9 2006. Keith Alexander has confirmed that the club have failed in a bid to bring Jon Parkin to the club for the time being. ...
Tigers pounce for ParkinJan 12, 2006 Football.co.uk, Hull City have completed their second signing in as many days after wrapping up a deal for Macclesfield striker Jon Parkin. The ...
Parkin agrees to sign for CityJan 11, 2006 sportnetwork.net, By Nathan Jackson - January 11 2006. Jon Parkin has agreed to join Championship relegation fodder, Hull City leaving the Imps with no known transfer targets. ...
Horton drops Parkin hintsJan 10, 2006 Vitalfootball, Macclesfield Town manager Brian Horton offered hope to Lincoln, and every other club interested in signing Jon Parkin, by revealing he won’t be signing any ...
Parkin's Price SetJan 10, 2006 Vitalfootball, Macclesfield are believed to want £225,000 for leading scorer Jon Parkin, according to the News of the World. Town don't want to ...
Tigers in for ParkinJan 11, 2006 Vitalfootball, Lincoln, and a host of other clubs, look set to miss out on the signing of Macclesfield Town striker Jon Parkin, with Championship side Hull City ready to ...
Shrimpers dismiss Parkin moveJan 9, 2006 Football.co.uk, Southend have completed the signing of Efe Sodje but have dismissed suggestions they have made a bid for Macclesfield's Jon Parkin. ...
John Parkin?Jan 11, 2006 Vitalfootball, It is reported that Macclesfield striker John Parkin is set to sign for the club, in a deal thought to be around the £100,000 mark. ...
Chester submit offer for ParkinJan 4, 2006 BBC Sport, Chester City have tabled a bid with League Two rivals Macclesfield Town for striker Jon Parkin. "We've done everything right as ...
CHESTER'S PARKIN BID REJECTEDJan 4, 2006 Sportinglife.com, Chester have had a bid for Macclesfield striker Jon Parkin rejected, with Silkmen chairman Rob Bickerton insisting the player is not for sale. ...
HORTON BLASTS PARKIN OFFERSJan 5, 2006 Sportinglife.com, Macclesfield manager Brian Horton believes offers the club have rejected for star striker Jon Parkin have been unrealistic. The ...
Parkin muscles in on WycombeJan 2, 2006 Telegraph.co.uk, Macclesfield's Jon Parkin appears to be 6ft 4in of solid muscle and League Two leaders Wycombe, having clawed their way back from 3-0 down to go ahead in a ...
PARKIN FINE AS MACC WIN THRILLERJan 2, 2006 Sportinglife.com, Jon Parkin's late double secured Macclesfield their first away win of the season thanks to an astonishing 5-4 triumph at Wycombe. ...
Parkin eyes January boostJan 4, 2006 Manchester Evening News, ROCHDALE boss Steve Parkin is determined to guide Rochdale back into the promotion frame after the club's rocky festive form. Dale ...
Macclesfield reject Parkin offersJan 5, 2006 BBC Sport, On Wednesday, Chester boss Keith Curle confirmed he was interested in Parkin, 24, who scored 25 goals last season and has netted eight this term. ...
Chester's Parkin bid failsJan 4, 2006 Vitalfootball, Lincoln City target Jon Parkin has been the subject of a £50,000 bid by Chester City. But Parkin's club Macclesfield Town have ...
Imps make Parkin manoeuvreJan 4, 2006 Vitalfootball, With Chester seeing their offer for much-sought-after Jon Parkin rebuffed, Lincoln have now tabled an undisclosed bid for the 24-year-old Macclesfield Town ...
Parkin bid rejectedJan 5, 2006 sportnetwork.net, By Nathan Jackson - January 5 2006. Macclesfield Town have rejected the Imps 6 figure + players transfer offer for prolific striker, Jon Parkin. ...
City make an official bid for Jon ParkinJan 4, 2006 sportnetwork.net, By Nathan Jackson - January 4 2006. Lincoln City have now officially made a bid for Macclesfield Town prolific defender-cum-striker, Jon Parkin. ...
Parkin is still just the ticketJan 5, 2006 ic CheshireOnline, By David Triggs, Chester Chronicle. KEITH Curle has refused to concede defeat in his quest to sign Macclesfield Town striker Jon Parkin. ...
Gorman eyes Parkin in the January salesJan 7, 2006 Bucks Free Press, JOHN Gorman saw two-goal striker Jon Parkin ruin his side's epic comeback on Monday and then admitted he wants to sign him. The ...
Chester pull out of Parkin raceJan 4, 2006 sportnetwork.net, By NatHan Jackson - January 4 2006. Chester have had a £50,000 bid for Jon Parkin rejected leaving only City's offer for the Silkmen to ponder. ...
Curle eyes renewed Parkin bidJan 7, 2006 Vitalfootball, After seeing a £50,000 bid for Lincoln target Jon Parkin turned down, Chester City manager Keith Curle still thinks there is hope of resurrecting a deal ...
Parkin Going Nowhere...Yet!Jan 5, 2006 Vitalfootball, Macclesfield have confirmed that they have recieved enquires for Parkin and turned down two offers from Chester(£50,000) and Lincoln, said to be six figures ...
Macc reveal Parkin bidsJan 5, 2006 Football.co.uk, Macclesfield have confirmed they have received several offers for star striker Jon Parkin but say they are determined to keep hold of the player. ...
Blues table Parkin bidJan 4, 2006 Football.co.uk, The 24-year-old netted 25 times for the Silkmen last season as they made the play-offs and has already notched eight goals since his return from injury a ...
Curle: We must stop Parkin chargeDec 30, 2005 ic CheshireOnline, KEITH Curle knows the Blues must shackle powerful striker Jon Parkin if they are to stand any chance of ending their three-match losing run at Moss Rose ...
Macclesfield decision could see Parkin arriveDec 19, 2005 sportnetwork.net, This could mean that the club will look to quickly offload it's most valuable players, namely, Jon Parkin, who has been linked with the Imps heavily over ...
Parkin blasts refDec 27, 2005 Soccer365, Rochdale boss Steve Parkin has slammed the referee in the wake of his side's 2-1 defeat to Wrexham. He said: "I've been very critical ...
Taylor aims to strike the right balanceJan 13, 2006 Yorkshire Post Today, PETER TAYLOR has this week spent £400,000 and broken the club transfer record to sign Darryl Duffy and Jon Parkin in an attempt to bolster his Hull City ...
Academic freedom issue first-contract hurdleJan 13, 2006 Western News, Western's Director of Faculty Relations and chief negotiator Michele Parkin says the academic freedom language in UWOFA's proposal for the librarians is ...
'I Will Get Goals'Jan 13, 2006 Vitalfootball, Parkin signed for the club on Wednesday in a deal around the £150,000 mark from League 2 side Macclesfield. At 6ft 4ins, he is ...
Parkin signs for HullJan 12, 2006 Manchester Evening News, ...visit of Crystal Palace. Macclesfield manager Brian Horton paid tribute to Parkin's contribution for the Silkmen. "As a manager ...
HULL WELCOME NEW STRIKERSJan 13, 2006 Sportinglife.com, New striker signings Darryl Duffy and Jon Parkin go straight into Peter Taylor's Hull squad for the home clash against Crystal Palace at the KC Stadium. ...
Preview: Macc v Oxford UtdJan 13, 2006 Manchester Evening News, MACC will have to face up to life without Jon Parkin when Oxford United arrive at Moss Rose this weekend. Parkin was snapped up ...
Hull City vs PalaceJan 13, 2006 Vitalfootball, City have two new strikers. Daryl Duffy has signed for £250,000 from Falkirk and John Parkin has signed for £150,000 from Macclesfield. ...
Chris Dagnall SignsJan 13, 2006 Vitalfootball, Steve Parkin has acted quickly to replace the departed Grant Holt. ... Steve Parkin came to watch when I played on Wednesday night in the reserves. ...
Tigers put faith in new boysJan 13, 2006 ic SouthLondon.co.uk, ...goal a season striker. He's pinning his hopes on his two new signings this week -Darryl Duffy and Jon Parkin. Lightning-quick Duffy ...
Preview: Town - BladesJan 13, 2006 sportnetwork.net, ...injury as is Jim Magilton. Adam Proudlock, Nicky Forster and Sam Parkin are all still out. Town manager Joe Royle: “Sheffield ...
Apple users rave over Intel MacsJan 11, 2006 ZDNet UK, ..."I've already asked my bosses for one of the 15-inch MacBooks," said Jim Parkin, an IT worker and Macworld attendee from Provo, Utah. ...
Spend...Spend... Spend...Jan 12, 2006 Vitalfootball, Peter Taylor is rumoured to be close to cpaturing the signature of Macclesfield town striker John Parkin for a fee thought to be around the £150,000 mark. ...
New Commodore banks on warm memories of the '80sJan 9, 2006 Boston Globe, Resurrecting a brand can be risky, said Paul Parkin, a principal with SALT Branding, a San Francisco firm. ... Older brands ''have a kitsch quality," Parkin said. ...
In computing, a blast from the pastJan 11, 2006 International Herald Tribune, ...factor. But resurrecting a brand can be risky, said Paul Parkin, a principal with SALT Branding, a San Francisco company. While ...
JONES FACES FITNESS FIGHTJan 11, 2006 Sportinglife.com, Boss Steve Parkin was keen to play down the extent of the injury, however, preferring to focus on the positive aspects of the midweek trip. ...
Swans set to bid for Dale hitmanJan 6, 2006 Manchester Evening News, Dale manager Steve Parkin is aware of Holt’s value to the side and to what extent his departure would hamstring the club’s bid for promotion. ...
Keith: I want more goalsJan 11, 2006 Vitalfootball, Jon Parkin has been Alexander's number one target for some time now, but he could well be forced to look elsewhere as Macclesfield are holding out for at least ...
PAT: Prime minister's parenting measures welcomeJan 10, 2006 Politics.co.uk, Philip Parkin, the new General Secretary of the Professional Association of Teachers (PAT), has welcomed the Prime Minister's commitment to the importance of ...
Championship Round-UpJan 15, 2006 SkySports, Hull City. Darren Ward and a Leon Cort own goal did the damage, although Jon Parkin marked his Hull debut with a goal. Watford remain ...
'World-class''Jan 13, 2006 Utah Statesman (subscription), Kari Parkin, a sophomore majoring in violin performance, said the hall's sound was wonderful and she was looking forward to the opportunity to perform in it. ...
Friends will rock in Megan's honorJan 6, 2006 Ardmore Main Line Life, ..."She would love this concert," Kelly Parkin said with a smile. "The bands are five of our favorite.". ... The music was their (Parkin's and Hayes') thing. ...
PAT: Head teacher shortage must be addressedJan 11, 2006 Politics.co.uk, General secretary Philip Parkin said a reduction in the number of failing schools of 50 per cent and a reduction by 75 per cent of low-achieving secondary ...
Lee handed Shefki's 32 shirtJan 11, 2006 Scottish Fitba, ...kick-start the Republic of Ireland forwards career, after a stale spell at Cardiff, much in the same way he did Kuqi's: "Nicky Forster and Sam Parkin will look ...
Epic fight ends in tearsJan 5, 2006 Bucks Free Press, ...were still celebrating their own great escape when Danny Whittaker skipped down the left and sent in a cross which the outstanding Jon Parkin flicked over the ...
A Win at Last!Jan 8, 2006 Vitalfootball, Goals from Stewart Talbot, Lee Canoville and Paul Ellender outweighed a single reply from Jonathan Parkin. Macclesfield started ...
Boston United 3 Macclesfield 1Jan 7, 2006 Manchester Evening News, The much sought after Jon Parkin reduced the deficit two minutes after the re-start but the visitors rarely looked like equalising and it was Boston who struck ...
First State follows name change trendJan 3, 2006 Memphis Business Journal, The Parkin, Ark.-based bank also announced plans Tuesday to open a loan production office in Germantown as well as to launch a new trust operation, Evolve ...
PAT: New general secretary announcementJan 4, 2006 Politics.co.uk, The Professional Association of Teachers (PAT) has welcomed its new General Secretary, Philip Parkin, who took up office on 1 January 2006, following the ...
Wycombe Wanderers 4 Macclesfield Town 5Jan 2, 2006 Manchester Evening News, Jon Parkin's stunning 81st-minute header ensured the Silkmen took maximum points for their three games over the festive period and extended their unbeaten run ...
Wycombe lose nine-goal thrillerJan 2, 2006 Times Online, Jon Parkin equalised and the forward added the winner four minutes later. The win moved Macclesfield up two places to sixteenth in the table. ...
MCARDLE EXTENDS SPOTLAND STAYJan 4, 2006 Sportinglife.com, The 18-year-old defender has spent five successful months at Spotland and has become a regular in Steve Parkin's promotion-chasing side. ...
UNITED END MACC RUNJan 7, 2006 Sportinglife.com, Boston ended Macclesfield's 10-game unbeaten run as goals from Stewart Talbot, Lee Canoville and Paul Ellender outweighed a single reply from Jon Parkin in a 3 ...
GORMAN BLAMES SCHEDULE FOR DEFEATJan 3, 2006 Sportinglife.com, Gorman, who has been suffering from a virus, saw his side fight back from 3-0 down to lead 4-3, only to be denied by Jon Parkin's double strike for the Silkmen ...
Striker-light Smith steps up his searchJan 5, 2006 ic NorthWales, Lincoln have also been tracking Chester target Jon Parkin of Macclesfield Town. Both Lincoln and Chester have tabled bids for Parkin ...
York hope for New Year bonusJan 4, 2006 confguide.com, The thisisyork website reports that former City star Jon Parkin is the prime candidate for a move away from Moss Rose to help generate money needed to pay a ...
Swans have Fallon bid rejectedJan 5, 2006 Vitalfootball, To get Holt it sounds as if we'll need to spend the whole of our £400,000 as Rochdale boss Steve Parkin says it'll take a ''substancial bid'' to secure his ...
League Two reviewJan 2, 2006 The Sun, John Parkin's late double sent the hosts to only their third loss this season as MACCLESFIELD'S 5-4 win confirmed their recent improvement. ...
Championship round-upJan 14, 2006 Telegraph.co.uk, Debutant Jon Parkin halved the deficit 60-seconds later with a neat finish but Hull failed to penetrate a well- organised defence. ...
Fireworks to light up AruaDec 28, 2005 The Monitor, Uganda, Asiki said on Tuesday that they had already obtained police permission to display the fireworks and a team of experts from Tomil Fireworks Limited, the ...
Home
Copyright phasechange.org 2006.
All Rights Reserved.
