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Etanercept
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DRUG INFO
Etanercept
Drug Name:
Etanercept
Indication: For treatment of severe adult and juvenille rheumatoid arthritis
Pharmacology: Used in the treatment of rheumatoid arthritis and the reduction of the adverse effects of tumor necrosis factor (TNF). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors.
Mechanism Of Action: There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation.
Drug Category: Immunomodulatory Agents; Antirheumatic Agents; unclassified therapeutic agents (92:00.00)
Brand Names/Synonyms: Tumor necrosis factor receptor superfamily member 1B precursor;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;p75;p80 TNF-alpha receptor;CD120b;Etanercept[Contains: Tumor necrosis factor binding protein 2;TBPII;TBP-2]; Enbrel (Immunex Corp)
Dosage Forms: KIT;LIQUID;POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human tumor necrosis factor receptor fusion protein
Chemical Formula: C2224H3475N621O698S36
Half Life: 102 +/- 30 hrs
Drug Type: Approved Drug
# Accession No: BIOD00052
CAS Registry Number: 185243-69-0
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Etanercept News
(When available)
Biotechs find themselves more coveted 15 Jan 2006
Philadelphia Inquirer, ...buy Immunex Corp. and its Enbrel medicine, approved to treat rheumatoid arthritis and the skin disease psoriasis. Amgen paid $1.4 ...
New treatments for rheumatoid arthritis Jan 14, 2006
Packet Online, ...new advances in RA treatment involve a new group of anti-inflammatory medications called biologic response modifiers, including Enbrel, Humira, Kineret and ...
Wyeth signs three biotech product deals Jan 9, 2006
philly.com, Currently, Wyeth sells seven biologic drugs, including the widely prescribed monoclonal antibody Enbrel for rheumatoid arthritis and the pneumococcal vaccine ...
Wyeth forecasts 10 percent EPS growth in 2006 Jan 9, 2006
Reuters Wyeth said it expects international revenue growth for the arthritis drug Enbrel to be in excess of 30 percent in 2006. Wyeth has ...
Wyeth, Trubion target arthritis, cancer Jan 3, 2006
Reuters ...$800 million. Wyeth's array of medicines includes the popular monoclonal antibody Enbrel for rheumatoid arthritis. Trubion's most ...
Trubion Starts New Year With Potential $840M Wyeth Deal Jan 3, 2006
BioWorld Online (subscription), In fact, both companies have on their development teams researchers and management responsible for developing Enbrel (etanercept), a blockbuster drug for ...
Psoriasis Drug May Also Clear Up Depression and Fatigue Dec 15, 2005
CNN 15 - At the same time that Enbrel (etanercept), a tumor necrosis factor-alpha (TNF-a) inhibitor, relieves the clinical symptoms of psoriasis, it may also clear ...
Psoriasis drug may also cut depression: study Dec 15, 2005
Reuters.uk, LONDON (Reuters) - Amgen Inc.'s psoriasis drug Enbrel appears to reduce depression and fatigue, as well as improving symptoms of the chronic skin disease ...
Psoriasis drug may treat depression, fatigue Dec 20, 2005
myDNA.com, A new study shows that the psoriasis drug called Enbrel (etanercept), made by the California-based Amgen company, appears to also reduce depression and fatigue ...
Wyeth, Trubion forge drug-development deal Jan 3, 2006
Reuters Wyeth, whose wide product line includes the popular rheumatoid arthritis drug Enbrel, said Trubion's most important product is an experimental drug for the ...
Outlook For Drugmakers Is Mixed Jan 12, 2006
TheDay (subscription), ...be driven by sales of Aranesp, a treatment for anemia in people with chronic renal failure and cancer patients on chemotherapy, as well as Enbrel, a treatment ...
News For Your Web Site Jan 9, 2006
dBusinessNews Seattle (press release), Dr. Smith and Dr. Ray Goodwin, a member of VLST's scientific advisory board, were co-inventors of Enbrel(R), a multi-billion-dollar biologic therapy developed ...
Amgen, Wyeth win court ruling on patent for arthritis drug Dec 24, 2005
Ventura County Star (subscription), Amgen Inc. and Wyeth won a court ruling that will end a lawsuit by an Israeli company seeking royalties on the arthritis treatment Enbrel. ...
Drug May Cut Psoriasis Depression Dec 15, 2005
WebMD Dec. 15, 2005 -- Enbrel, a drug approved to treat rheumatoid and psoriatic arthritis, might also help psoriasis patients mentally and physically. ...
Bristol Climbs on FDA Approval Dec 27, 2005
Red Herring, However, the company faces competition from some older medications, such as Johnson & Johnson’s Remicade and Amgen’s Enbrel. ...
Bristol-Myers gets FDA approval for arthritis drug Dec 24, 2005
Economic Times, ...therapies. Older treatments include Abbott Laboratories Inc's Humira, Johnson & Johnson's Remicade and Amgen Inc's Enbrel. Three ...
Wyeth 2006 forecast misses Street views Jan 9, 2006
San Jose Mercury News, Essner noted Effexor, Enbrel for rheumatoid arthritis and Wyeth's infant formula and other nutritional products all should report $1 billion in revenues from ...
Seattle biotech strikes deal with drug giant Jan 4, 2006
Seattle Post Intelligencer Several executives and researchers from the two companies worked together to develop Enbrel, the rheumatoid arthritis drug developed in the Seattle ...
Medicare expands tier pricing system Jan 3, 2006
USA Today ...most commonly pay 25% to 33% of the cost of the drug rather than a flat dollar amount — are such expensive treatments as Remicade and Enbrel for rheumatoid ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), 2003, biologic drugs approved for psoriatic arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab, sold ...
Trigger for Common Skin Disease Found Jan 10, 2006
Newswise (press release) Current treatments for psoriasis such as the drug Enbrel focus on these inflammatory hormones, but the researchers were able to stop the development of ...
Bristol-Myers Squibb Receives US Approval for Arthritis Drug Dec 23, 2005
New York Times, ...status. Orencia will compete with Enbrel by Amgen, Remicade by Johnson & Johnson and Humira by Abbott - all called anti-TNF agents. ...
Amgen acquires Abgenix Dec 15, 2005
Boston Globe, The acquisition would be Amgen's biggest since it bought Immunex in 2002 for $8.8 billion, gaining the rheumatoid arthritis drug Enbrel. ...
Amgen to acquire Abgenix for $2.2bn Dec 15, 2005
New Ratings The acquisition marks the largest one since Amgen took over Immunex in 2002 for $8.8 billion to gain the rheumatoid arthritis drug Enbrel. ...
FDA OKs Bristol-Myers rheumatoid arthritis drug Dec 23, 2005
Herald News Daily, ...one or more other therapies. Older tre - ) Humira, Johnson & Johnson‘s (NYSE: - ) Remic - ) Enbrel. Three Bristol-Myers studies ...
Biologic drugs the latest psoriasis weapon Dec 20, 2005
United Press International It as well as Amevive, Enbrel, Humira and Raptiva have been approved to treat psoriasis and psoriatic arthritis since 2003, the newspaper reported. ...
Commercial Insight: Disease Modification in Rheumatoid Arthritis ... Dec 20, 2005
Pharmaceutical Business Review However, the recent launch of Enbrel and forecast launch of Humira in this market is expected to push the biologic class above traditional DMARDs by 2010 in ...
Amgen Buys a Potential Blockbuster Dec 15, 2005
BusinessWeek As one analyst in the post-deal call pointed out, when Amgen bought Immunex in 2002 for $10 billion, it predicted that Immunex's drug Enbrel for rheumatoid ...
Local Residents needed for dermatology studies Dec 14, 2005
KOLO, Iinjectable drugs..Raptiva and Enbrel have been shown to be very affective at treating psoriasis. ... Betty has found relief with the drug Enbrel. ...
Easing psoriasis blues Dec 16, 2005
Health24.com, Etanercept, which goes under the brand name Enbrel, works by blocking a protein called tumour necrosis factor-alpha (TNF-alpha), which is produced by the body ...
Amgen to Buy Abgenix, Getting Complete Control of New Colon Cancer ... Dec 14, 2005
New York Times, ...discovery prowess. In 2002, it paid about $10 billion for Immunex to obtain the big-selling rheumatoid arthritis drug, Enbrel. The ...
Wyeth's Biotech Bet Jan 4, 2006
Motley Fool Several of them worked on Enbrel, the monoclonal antibody for rheumatoid arthritis now marketed by Wyeth and Amgen (Nasdaq: AMGN). ...
US okay for B-MS' blockbuster candidate Jan 2, 2006
Pharma Times (subscription), ...such as methotrexate but also the new anti-tumor necrosis factor products such as Johnson & Johnson's Remicade (infliximab), Wyeth's Enbrel (etanercept) and ...
Business news in brief Dec 24, 2005
Philadelphia Inquirer, Bloomberg News. Amgen Inc. and Wyeth won a ruling that would end a lawsuit by an Israeli company seeking royalties on the arthritis treatment Enbrel. ...
Psoriasis Drug May Also Fight Depression Dec 14, 2005
HealthCentral.com Etanercept, which goes under the brand name Enbrel, works by blocking a protein called tumor necrosis factor-alpha (TNF-alpha), which is produced by the body ...
Bristol-Myers Shares Gain in Europe After US Clears Drug Dec 27, 2005
Bloomberg It is more disabling than the more common osteoarthritis form of the disease. Existing treatments for rheumatoid arthritis include Enbrel, sold by Amgen Inc. ...
Bristol-Myers shrs up 2 pct after Orencia approval Dec 27, 2005
Washington Post, ...treatments. Those treatments include big-selling drugs, such as Amgen Inc.'s Enbrel and Johnson & Johnson Inc.'s Remicade. "The ...
Bristol-Myers shrs up 2 pct after Orencia approval Dec 27, 2005
Reuters Those treatments include big-selling drugs, such as Amgen Inc.'s (AMGN.O: Quote, Profile, Research) Enbrel and Johnson & Johnson Inc.'s (JNJ.N: Quote, Profile ...
Bristol-Myers Wins FDA Approval for Orencia Treatment (Update2) Dec 23, 2005
Bloomberg Existing treatments for rheumatoid arthritis include Enbrel, sold by Amgen Inc. and Wyeth, Johnson & Johnson's Remicade and Abbott Laboratories' Humira. ...
Abgenix German Shares Jump on Amgen's $2.2 Billion Cash Offer Dec 15, 2005
Bloomberg It would be Amgen's biggest transaction since the company bought Immunex in 2002 for $8.8 billion, gaining the rheumatoid arthritis drug Enbrel. ...
S&P Upgrades Univision to Strong Buy Dec 27, 2005
BusinessWeek However, its potential is limited by the FDA's restriction of the drug to patients who fail to respond to existing drugs, such as Enbrel and Remicade. ...
Amgen initiated with "buy" Dec 16, 2005
New Ratings ...this morning, the analyst mentions that the performance of Amgen's core business remains robust, driven by the company's Aranesp, Neulasta and Enbrel drugs. ...
Zacks.com announces that Nadine Wong highlights: Abgenix and Amgen Dec 21, 2005
Business Wire (press release), ...growth. Despite changes to Medicare reimbursement, the company will remain competitive in the EPO and Enbrel markets. Successful ...
Wyeth opens Dublin drug discovery research facility Dec 22, 2005
DrugResearcher.com, With more than $17.4 billion in revenue this includes such innovative products as the rheumatoid arthritis drug Enbrel (etanercept), ReFacto (antihemophilic ...
Duke in the News: Dec. 15, 2005 Dec 15, 2005
Duke University, 14 -- The psoriasis drug Enbrel appears to reduce depression and fatigue, as well as improving symptoms of the chronic skin disease, Duke researchers say. ... ...
Juvenile Arthritis - A Niche In The Market Dec 20, 2005
Pharmaceutical Business Review ...for tax credit and marketing incentives, and all three biologic TNF-inhibitors currently have orphan designation in the US but only Enbrel (etanercept) is ...
Wyeth to establish a Bio-therapeutic Drug Discovery Research ... Dec 21, 2005
Biotechnology Ireland, Crohn's disease and a range of other complaints; Fusion Proteins, which is a class of drugs that is exemplified by Wyeth's flagship product, Enbrel, used for ...
Amgen's blockbuster anemia drugs facing patent challenge Dec 24, 2005
Providence Journal (subscription), But Amgen, the world's largest biotechnology company, which manufactures the rheumatoid arthritis drug Enbrel in West Greenwich, will not give up its empire ...
Biotechs find themselves more coveted Jan 15, 2006
Philadelphia Inquirer, ...developing together. The acquisition was the third major purchase for Amgen since 2002, when it paid $11 billion to buy Immunex Corp. and ...
News For Your Web Site Jan 9, 2006
dBusinessNews Seattle (press release), Dr. Gillis, a biotech pioneer, co-founded both Immunex and Corixa and served as chairman and chief executive officer of both companies. ...
Seattle biotech strikes deal with drug giant Jan 4, 2006
Seattle Post Intelligencer Founded in 2002 by former executives of Chiron, Immunex and Xcyte Therapies, Trubion employs just 40 people at its downtown Seattle headquarters. ...
Trubion Starts New Year With Potential $840M Wyeth Deal Jan 3, 2006
BioWorld Online (subscription), Enbrel was first developed at Immunex Corp., of Seattle, in collaboration with American Home Products. Immunex later merged with ...
Wyeth, Trubion target arthritis, cancer Jan 3, 2006
Reuters He noted that several top executives of Trubion once worked at Immunex, the US biotech company that developed Enbrel with Wyeth, which was then called American ...
Amgen Buys Abgenix for $2.2B Dec 16, 2005
Red Herring, The two companies have been partnering on developing a cancer treatment known as panitumumab since 2002, when Amgen acquired Immunex. ...
Amgen Buys a Potential Blockbuster Dec 15, 2005
BusinessWeek ..."A WONDERFUL ACHIEVEMENT." As one analyst in the post-deal call pointed out, when Amgen bought Immunex in 2002 for $10 billion, it predicted that Immunex's ...
Amgen to Buy Abgenix, Getting Complete Control of New Colon Cancer ... Dec 14, 2005
New York Times, In 2002, it paid about $10 billion for Immunex to obtain the big-selling rheumatoid arthritis drug, Enbrel. The Immunex acquisition ...
Amgen to Acquire Abgenix for $2.2 Billion in Cash (Update3) Dec 14, 2005
Bloomberg The acquisition would be Amgen's biggest since it bought Immunex in 2002 for $8.8 billion, gaining the rheumatoid arthritis drug Enbrel. ...
Abgenix German Shares Jump on Amgen's $2.2 Billion Cash Offer Dec 15, 2005
Bloomberg It would be Amgen's biggest transaction since the company bought Immunex in 2002 for $8.8 billion, gaining the rheumatoid arthritis drug Enbrel. ...
Ex-Dendreon exec joins VLST Corp. Jan 6, 2006
Seattle Post Intelligencer ...executive chairman. Gillis, co-founder of Immunex and Corixa, is a partner in the Seattle office of ARCH Venture Partners. Simonetti's ...
Simonetti, Gillis join VLST Jan 6, 2006
Seattle Post Intelligencer ...executive chairman. Gillis, co-founder of Immunex and Corixa, is a new partner in the Seattle office of Arch Venture Partners. Arch ...
Biotech behemoth beefs up Dec 15, 2005
Los Angeles Daily News, After buying Immunex in 2002, Thousand Oaks-based Amgen began working closely with Abgenix on a development and commercialization strategy for panitumumab. ...
Amgen to acquire Abgenix for $2.2bn Dec 15, 2005
New Ratings The acquisition marks the largest one since Amgen took over Immunex in 2002 for $8.8 billion to gain the rheumatoid arthritis drug Enbrel. ...
Amgen seals deal to buy Abgenix for $2.2 billion Dec 15, 2005
9NEWS.com, ...a drug for colon, head and neck cancers the companies have been developing jointly since 2002 under an agreement Amgen assumed with its purchase of Immunex. ...
Amgen to Buy Drug Firm Dec 15, 2005
Los Angeles Times, The acquisition confirms Amgen's enthusiasm for Panitumumab, a drug that came to Amgen as a result of its 2002 purchase of Immunex Corp., Abgenix's original ...
Amgen to acquire biotech working on cancer drugs Dec 15, 2005
Seattle Times, ...are developing. Abgenix had earlier sold half the drug's future profits to Seattle's Immunex, which Amgen acquired in 2002. Amgen ...
Amgen to acquire Abgenix for $2.2 billion Dec 15, 2005
San Jose Mercury News, The drug would have been Abgenix's first commercial product. Abgenix had been developing panitumumab with Immunex, which Amgen acquired in 2002. ...
Psoriasis Drug May Also Clear Up Depression and Fatigue Dec 15, 2005
CNN ...patients with psoriasis with high levels of depression and fatigue," they said. The study was funded by Immunex, which markets Enbrel.
Amgen Offers To Buy Out Abgenix For $2.2B In Cash Dec 14, 2005
BioWorld Online (subscription), ...a monoclonal antibody for colorectal cancer partnered with Amgen, which began working with Abgenix on the compound after acquiring Immunex Corp., of Seattle ...
Amgen to buy Abgenix Dec 14, 2005
Providence Journal (subscription), Abgenix had earlier sold half the drug's future profits to Immunex Corp., which Amgen acquired in 2002. Abgenix is also developing an osteoporosis drug. ...
Amgen to purchase Abgenix Dec 15, 2005
Contra Costa Times, Amgen's partnership with Abgenix began in 2002, when the Thousand Oaks-based company took over co-development of panitumumab from Immunex Corp. ...
Amgen to Acquire Abgenix for $22.50 Per Share; Provides Amgen With ... Dec 14, 2005
Finanzen.net, ...panitumumab.Working closely with Abgenix under a co-development agreement thatAmgen assumed as a result of its acquisition of Immunex Corporation in2002, Amgen ...
Psoriasis drug may also cut depression: study Dec 14, 2005
Herald News Daily, Enbrel was originally discovered by Immunex, now part of Amgen, and jointly developed with Wyeth, which markets the product outside North America.
Study reveals how second-hand smoke damages the health of children ... 16 Jan 2006
Newstarget.com, ...children do in school.". In the study, researchers examined the gene called tumor necrosis factor (TNF) alpha. This particular gene ...
Calorie Restricters Seem Young at Heart Jan 13, 2006
CNN They also measured inflammatory markers, including C-reactive protein, tumor necrosis factor-alpha, and transforming growth factor-beta1. ...
Caloric Restriction Appears To Prevent Primary Aging In The Heart Jan 13, 2006
Science Daily (press release) ...group. Their serum levels of a pro-inflammatory molecule called tumor necrosis factor-alpha (TNFa) were significantly lower. They ...
Drug Combo Works Best for Rheumatoid Arthritis Jan 9, 2006
Forbes 9 (HealthDay News) -- A combination of anti-TNF (tumor necrosis factor) and DMARD (disease-modifying antirheumatic drug) therapies achieved remission of early ...
Fish Oil Supplements Prevent Exercise Airway Constriction in ... Jan 9, 2006
Medscape (subscription) ...supplemented diet was associated with a significant drop in a number of sputum inflammatory mediators, such as leukotriene C4 and tumor necrosis factor-alpha. ...
Pretreating with Aspirin can induce cancer cells previously ... Jan 8, 2006
Xagena.it, ...researchers at the University of Pittsburgh, report that Aspirin, combined with a promising new cancer therapy known as tumor necrosis factor-related apoptosis ...
Recent Advances in Biologic Therapies Jan 6, 2006
Medscape (subscription) The tumor necrosis factor (TNF) inhibitors are highly effective, but, unfortunately, as with other disease-modifying antirheumatic drugs (DMARDS), a number of ...
Early Rheumatoid Arthritis Treatments Weighed Dec 29, 2005
Journal of American Medical Association (subscription), ...drugs (DMARDs), either sequentially or in a step-up combination (with or without a corticosteroid) or coupled with a tumor necrosis factor antagonist biologic. ...
Secondhand Smoke Affects Some Kids More Dec 26, 2005
Ivanhoe, ...(Ivanhoe Newswire) -- Secondhand smoke affects all children, but a new study reveals children who possess a gene called tumor necrosis factor 308A are affected ...
US okay for B-MS' blockbuster candidate Jan 2, 2006
Pharma Times (subscription), ...drugs for RA, including the disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate but also the new anti-tumor necrosis factor products such as ...
Bristol-Myers Squibb Company Announces Submission of ORENCIA ... Jan 4, 2006
PharmaLive.com (press release), ...had an inadequate response to one or more disease-modifying anti-rheumatic drugs (DMARDs), such as methotrexate (MTX) or tumor necrosis factor (TNF) antagonists ...
Evidence supports combination therapy for achieving remission of ... Jan 8, 2006
News-Medical.net, ...issue of Arthritis & Rheumatism presents the first study to compare the effectiveness of DMARD therapy alone, anti-TNF (tumor necrosis factor) therapy alone ...
Second-Hand Smoke Hits Genetically Susceptible Kids Harder Dec 20, 2005
Newswise (press release) They found that genetic susceptibility caused by a variant genotype called “tumor necrosis factor 308A� influences the risk of respiratory-related school ...
New evidence to support combination therapy for achieving ... Jan 3, 2006
EurekAlert (press release), ...wiley.com/journal/arthritis) presents the first study to compare the effectiveness of DMARD therapy alone, anti-TNF (tumor necrosis factor) therapy alone, and ...
News tips from the Journal of Neuroscience Jan 4, 2006
EurekAlert (press release), The authors report that TACE, the tumor necrosis factor-á converting enzyme, is required for the TGFá–erB1 signaling in hypothalamic astrocytes. ...
Study This Jan 7, 2006
Bryan College Station Eagle, ...an anti-inflammatory) and prednisone; or (4) a combination of methotrexate and infliximab, a drug that blocks a substance (tumor necrosis factor) that causes ...
Bristol Climbs on FDA Approval Dec 27, 2005
Red Herring, He added that Orencia was only likely to be used by patients that fail with Enbrel or another anti-TNF (tumor necrosis factor) drug, and that will make it a ...
Two drugs better than one for RA: study Dec 30, 2005
Reuters.uk, ...study. Humira is a human antibody designed to block a protein known as tumor necrosis factor, which plays a key role in inflammation. ...
FDA OKs New Rheumatoid Arthritis Drug Dec 27, 2005
WebMD ...the patients had tried methotrexate and biologic drugs such as anti-TNF drugs that target an inflammatory protein called TNF (tumor necrosis factor). ...
FDA approves Orencia Dec 29, 2005
myDNA.com, ...had an inadequate response to one or more disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX) or tumor necrosis factor (TNF) antagonists ...
FDA OK's Bristol Myers' arthritis drug Dec 27, 2005
United Press International T-cell activation, the company said, and is also the first RA therapy proven safe and effective for patients for whom tumor necrosis factor (TNF) antagonists ...
Global Inflammation: a Cardiovascular Risk Marker in Women Dec 28, 2005
Medscape (subscription) No clusters of these or other markers, including tumor necrosis factor alpha, were independently associated with angiographic coronary artery disease. ...
Investigative Antiviral Agent Aplaviroc Lowers Viral Load without ... Dec 22, 2005
DG News ...interleukin-8 (IL-8), membrane cofactor protein-1 (MCP-1), and T helper 1 (TH 1) and T helper 2. The cytokines consisted of tumor necrosis factor-alpha (TNF ...
Psoriasis drug may treat depression, fatigue Dec 20, 2005
myDNA.com, Dec. 15. Enbrel works by blocking tumor necrosis factor-alpha (TNF-alpha), which is produced by the body during inflammation. High ...
Secondhand smoke makes kids sick Dec 18, 2005
myDNA.com, ...children do in school.". In the study, researchers examined the gene called tumor necrosis factor (TNF) alpha. This gene is linked ...
Second-Hand Smoke Poses Increased Risk of Respiratory Problems to ... Dec 20, 2005
Newsinferno.com, In the study, researchers from the Keck School of Medicine of the University of Southern California looked at tumor necrosis factor (TNF) alpha, a gene ...
TNF- -induced chemokine production and apoptosis in human neural ... Dec 20, 2005
Journal of Leukocyte Biology In this study, the effects of tumor necrosis factor (TNF- ) on cytokine and chemokine production by human NPCs (>98% nestin- and >90% A2B5-positive), obtained ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), Remicade, Enbrel and Humira aim at a different player, a protein called TNF-alpha, for tumor necrosis factor-alpha, that is an important immune activator in ...
FDA Approvals: Orencia and Revlimid Dec 29, 2005
Medscape (subscription) ...who have had inadequate response to one or more disease-modifying antirheumatic drugs (DMARDS) such as methotrexate or tumor necrosis factor (TNF) antagonists. ...
Aspirin may help cancer drug work Dec 18, 2005
Pittsburgh Post Gazette, ...week in the Journal of Biological Chemistry that aspirin appears to sensitize certain cancer cells to a protein called tumor necrosis factor-related apoptosis ...
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