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Epoetin alfa
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DRUG INFO
Epoetin alfa
Drug Name:
Epoetin alfa
Indication: For treatment of anemia (from renal transplants or certain HIV treatment)
Pharmacology: Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Mechanism Of Action: Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Drug Category: Antianemic Agents; hematopoietic agents (20:16.00)
Brand Names/Synonyms: Erythropoietin precursor;Epoetin; Epogen (Amgen Inc.); Epogin (Chugai); Epomax (Elanex); Eprex (Janssen-Cilag. Ortho Biologics LLC); NeoRecormon (Roche); Recormon (Roche); Procrit (Ortho Biotech)
Dosage Forms: SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human erythropoietin
Chemical Formula: C815H1317N233O241S5
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00103
CAS Registry Number: 11096-26-7
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Epoetin alfa News
(When available)
3 murder suspects escape 15 Jan 2006
Bradenton Herald, ...continued searching for them. The two still on the run were Johnny Earl Jones, 17, and Lamar Elan Benton, 19. Russell Sheriff Tommy ...
National Semiconductor Says China Sales Growth to Double to 20% 15 Jan 2006
Bloomberg The US chipmaker is targeting a rate higher than China's industry average of more than 10 percent for analog chips, Elan Lee, National Semiconductor's China ...
What's in store 15 Jan 2006
Detroit Free Press, Played with sharp, deadpan elan by Trenton native Mary Lynn Rajskub, Chloe has become the MVP of supporting players on "24." She even had a chance to grab a ...
Letterkenny's students show plenty of investment team spirit 15 Jan 2006
Unison.ie, The common thread between the leading entries in both sections is their choice of the top two best shares, Elan (up 78pc) and Marks & Spencer (45.5pc). ...
Test of fire for Bangalore City police 15 Jan 2006
Deccan Herald, Not for any spiritual gains, but to overcome fear and build confidence. The policemen from the Bangalore East Division performed it with elan. ...
'Star Spangled' show will return to Greensboro 15 Jan 2006
Greensboro News Record, The Allied drive into North Korea, started with such elan and expectations, had foundered when Chinese Communist Forces entered the war in huge numbers: In ...
Elan Announces Webcast of Fourth Quarter and Full Year 2005 ... Jan 13, 2006
Genetic Engineering News, Elan Corporation, plc announced today that it will host a conference call on Tuesday, January 31, 2006 at 8:30 am Eastern Standard Time (EST), 1:30 pm ...
ELAN HOME SYSTEMS ANNOUNCES THP800C POINTABLE HOME THEATER ... Jan 12, 2006
Home Toys (press release), LEXINGTON, KY -- ELAN Home Systems, a leading manufacturer of award-winning Multi-Room audio/video and home automation systems, announced today that the ...
Wife stops murdered doctor's cremation Jan 14, 2006
Trinidad & Tobago Express, Sumatie Elan, the woman claiming to be the wife of murdered city doctor, Ravi Maharaj, has filed an injunction against his relatives preventing them from ...
Elan downgraded to "add" Jan 13, 2006
New Ratings LONDON, January 13 (newratings.com) - Analyst Ian Hunter of Goodbody Stockbrokers downgrades Elan (ELN.NYS) from "buy" to "add." The target price is set to ...
MARKET COMMENT: Dublin Stocks End Flat, Elan +3.1% Jan 12, 2006
New Ratings Elan +3.1% as investors await more news on the FDA's review of MS drug Tysabri. Financials mixed: Anglo Irish Bank -1.4%, Irish Life & Permanent +1.3%. ...
Senior Synchronized Skating Team Grabs First at the Mid-America ... Jan 14, 2006
Miami Redhawks, ...second place Team Fusion. Team Elan of the Detroit Skating Club finished third followed by the University of Michigan. "I was very ...
My baby? It's a mixed basket of Ireland Inc Jan 14, 2006
Irish Independent, However, I invested in only one company, Elan, to express that view. ... The whole sector did not collapse because Elan had company and product-specific problems. ...
Elan and EntreMed tie up technology deal Jan 10, 2006
RTE.ie, Elan has entered into a license agreement in which EntreMed will use its nanocrystal technology to develop its oncology drug Panzem. ...
Elan and EntreMed agree NanoCrystal technology deal Jan 11, 2006
In-PharmaTechnologist.com, 11/01/2006 - EntreMed have entered into a new agreement with Elan, which allows the clinical-stage pharmaceutical company to utilise Elan's NanoCrystal ...
Ex-Biogen counsel to pay $3m Jan 13, 2006
Boston Globe, Ten days later, Biogen Idec and its partner, Elan Corp., made the stunning disclosure that they were suspending sales of Tysabri. ...
Elan, EntreMed Ink License Pact Jan 10, 2006
TheStreet.com Elan (ELN:NYSE ADR - commentary - research - Cramer's Take) signed a license agreement granting EntreMed (ENMD:Nasdaq - commentary - research - Cramer's Take ...
Elan and EntreMed Execute License Agreement for Proprietary ... Jan 10, 2006
PharmaLive.com (press release), DUBLIN, Ireland and ROCKVILLE, Md., January 10, 2006 /PRNewswire-FirstCall/ -- Elan Corporation, plc and EntreMed, Inc. today announced ...
ELAN AND ENTREMED EXECUTE LICENSE AGREEMENT Jan 10, 2006
Small Times Jan. 10, 2006 - Elan Corp. plc (NYSE: ELN) and EntreMed Inc. ... Additionally, Elan will receive royalty payments based on sales of Panzem NCD. ...
Elan drives market advance Jan 11, 2006
IrishExaminer.com, THE Irish market increased on the back of strong gains in Elan. The ISEQ Index finished up 19.20 points at 7494.37. AIB rose by ...
Elan Tysabri Could Hit $1.8B Sales - NCB Jan 11, 2006
New Ratings ...negative sentiment." Maintains at buy. Elan +3.3% at EUR12.25. (QAF). Contact us in London. +44-20-7842-9464 Markettalk.eu@dowjones.com.
Accent Supplies Caliper Elan Overlay Tool to AMD Inc. Jan 9, 2006
Business Wire (press release), ...leading supplier of lattice engineering and photolithography process control tools, today announced the successful deployment of its Caliper elan 300mm overlay ...
Roller-coaster ride for Elan shareholders on back of Tysabri Jan 3, 2006
Biotechnology Ireland, Shareholders in Elan are getting used to a roller-coaster ride when it comes to the performance of the pharmaceutical company. The ...
Loving Elan's Latest Comeback Jan 4, 2006
Forbes ...tracking and analysis service Marketocracy, recommends buying the American depositary receipts for shares of Irish biotechnology and drug delivery company Elan ...
Elan shares buoyed by hopes for Tysabri Dec 16, 2005
Reuters DUBLIN (Reuters) - Shares in Irish drug maker Elan (ELN.I: Quote, Profile, Research) rose in Dublin on Friday, playing catch-up on a jump overnight in New York ...
ISEQ up as Elan continues recovery Dec 16, 2005
Ireland Online, Pharmaceutical giant Elan continued its remarkable recovery today as the ISEQ index shot up 95.64 points to 7254.89 today to end the week on a high. ...
Elan, financials drag ISEQ down Dec 19, 2005
Ireland Online, Insurer FBD was up €1.08 (3%) at €37.23. The group today issued a promising pre-close trading statement. The financials, however, had a poor day. ...
Michael Jahn Joins ELAN GMK Dec 26, 2005
PR Web (press release), Simi Valley, CA. (PRWEB) December 26, 2005 -- ELAN GMK, the global authority on imaging, printing and digital document delivery solution, today announced the ...
Elan to Present at Healthcare Conferences in January 2006 Dec 22, 2005
Business Wire (press release), DUBLIN, Ireland--(BUSINESS WIRE)--Dec. 22, 2005--Elan Corporation, plc announces that it will present at two healthcare conferences in January 2006. ...
Elan to Present at Healthcare Conferences in January 2006 Dec 22, 2005
Finanzen.net, On January 5, 2006, Elan will present at the Morgan StanleyPharmaceutical CEO's Unplugged Conference in New York at 8:00 amEastern Standard Time (EST), 1:00pm ...
Elan shares surge 8pc on Dublin market Dec 16, 2005
Unison.ie, SHARES in drugmaker Elan finished the day higher on the Irish market yesterday. Elan stock closed up over 8pc at €11.69. The shares ...
Elan "buy" Dec 28, 2005
New Ratings LONDON, December 28 (newratings.com) - Analyst Ian Hunter of Goodbody Stockbrokers maintains his "buy" rating on Elan Corp Plc (DRX.FSE). ...
Elan share price may drift on a lack of news Dec 29, 2005
Unison.ie, SHARES in Elan are set to fall back in January following a strong run in early December which saw the stock's value rise by 38pc in just 15 days, a leading ...
Elan Nutrition, Inc. Develops Award Winning Bar Dec 29, 2005
NPIcenter (press release), Elan Nutrition, Inc., a leading developer and contract packer of nutrition bars based in Grand Rapids, Michigan, was recently honored with a CSP Retailer ...
Ryanair and Elan lead ISEQ recovery Dec 21, 2005
Irish Examiner, THE ISEQ index recovered yesterday led by gains in Ryanair and Elan. At the closing bell, the Dublin Exchange had risen 49.51 points to 7226.79. ...
Elan Nutrition Receives NSF Certification Dec 29, 2005
NPIcenter (press release), Elan Nutrition has received notification that the company’s facility in Grand Rapids , Michigan has passed the NSF GMP Certification for functional foods and ...
Merrill Lynch issues 'sell' rating on Elan Dec 24, 2005
Unison.ie, IN a major new report on the biotech sector, international investment bank, Merrill Lynch, has recommended selling Elan shares as its top European sell idea ...
Elan "sell" Dec 20, 2005
New Ratings NEW YORK, December 20 (newratings.com) – Analysts at Merrill Lynch reiterate their "sell" rating on Elan Corp (ELN.NYS). In a ...
Sharp fall in Elan as Merrill says 'sell' Dec 20, 2005
Unison.ie, SHARES in Elan fell sharply yesterday after US investment house Merrill Lynch advised investors to sell the drug company's shares. ...
Elan Momentum Seen Easing Over Holidays Dec 19, 2005
New Ratings 1229 GMT [Dow Jones] Elan -4.2% at EUR11.20 in profit-taking after a 30%-plus gain since the start of December, says Goodbody Stockbrokers' Ian Hunter. ...
Elan plunges 462 places on BusinessWeek's Global 1200 company ... Dec 19, 2005
FinFacts Ireland, Some big companies such as Google are not part of this index. The magazine says: Pity the shareholders of Irish drugmaker Elan Corp., for example. ...
Elan Etap Moody Oyster and Shipman lead in Awards Dec 16, 2005
Sail World, The Croatian Elan 434, ‘Unsinkable’ Etap46DS from the Netherlands, the British Moody 49 and Oyster 72 are the sailing boats over 40ft short-listed to take ...
Local artists’ work at Chateau Elan Dec 15, 2005
The Citizen.com, The League of Fine Artists South (LOFAS) will exhibit in the gallery at The Winery -Chateau Élan in December. Five fine artists ...
Braselton plans visitors bureau to market town Jan 12, 2006
Main Street Newspapers, Braselton already receives a five percent hotel/motel tax for room lodging from the town’s three hotels — The Inn at Chateau Elan, Holiday Inn Express at ...
Doctor beaten to death Jan 12, 2006
Trinidad News, ...gun. Maharajh’s common-law-wife, Sumatie Elan, found him lying unconscious and face down on the floor at about 1 pm yesterday. ...
UPDATE 1-Ex-Biogen exec to pay $3 mln for insider trading Jan 12, 2006
Reuters The case stems from Biogen's suspension last February of the multiple sclerosis drug Tysabri after the company along with development partner Elan Corp. ...
XM-R3™ TRIPLE SATELLITE AUDIO RECEIVER FROM ELAN® HOME SYSTEMS ... Dec 12, 2005
Home Toys (press release), Lexington, KY-- ELAN® Home Systems, a leading manufacturer of award-winning Multi-Room audio/video and home control systems, announced today that the company ...
Elan Ships Triple XM Receiver Dec 13, 2005
Designtechnica, Elan Home Systems, a manufacturer of multi-room audio/video and home automation systems, recently announced a new receiver component geared towards XM ...
UK's Stocks Decline, Paced by Shire, Vodafone; ISEQ Advances Jan 13, 2006
Bloomberg The FTSE All-Share Index slid 0.6 percent to 2886.64. Ireland's ISEQ Overall Index rose 10.94, or 0.2 percent, to 7532.99, buoyed by Elan Corp. ...
Elan and EntreMed Execute License Agreement for Proprietary ... Jan 9, 2006
TMCnet 10, 2006 -- Elan Corporation, plc (NYSE: ELN) and EntreMed, Inc. ... Additionally, Elan will receive royalty payments based on sales of Panzem(R) NCD. ...
Elan and EntreMed Execute License Agreement for Proprietary ... Jan 9, 2006
PR Newswire (press release), DUBLIN, Ireland and ROCKVILLE, Md., Jan. 10 /PRNewswire-FirstCall/ -- Elan Corporation, plc (NYSE: ELN) and EntreMed, Inc. (Nasdaq ...
Elan and EntreMed Execute License Agreement for Proprietary ... Jan 9, 2006
Finanzen.net, Elan Corporation, plc (NYSE: ELN) and EntreMed, Inc.(NASDAQ: ENMD) today announced that they have entered into a LicenseAgreement in which EntreMed has been ...
Amerin stock surges by 20pc on drug results Jan 13, 2006
Unison.ie, AMERIN, the drug company chaired by former Elan finance director Tom Lynch, saw its shares rise 20pc in early trading on the Nasdaq last night. ...
IFG climbs 16pc on broker reports Jan 13, 2006
Unison.ie, It was followed by drug manufacturer Elan which gained 13pc. Elan shares gained after an investor conference at its Tysabri research partner Biogen. ...
Back in hot seat with quiver full of gold-tipped arrows Jan 14, 2006
Unison.ie, Thanks to a sharp recovery by Elan late in the year, George's stocks ended up just about in positive territory, with an average gain of 2.4 per cent. ...
Approval to restart Phase IIa trial in MS patients Jan 12, 2006
Biotech Intelligence (press release), This trial was voluntarily halted by Antisense Therapeutics in March 2005 in light of safety issues associated with Biogen Idec and Elan Corporation's multiple ...
Manpower Inc. to Announce 4th Quarter and Full-Year 2005 Earnings ... Jan 12, 2006
Finanzen.net, In addition to the Manpower brand, the company operates under the brand names of Right Management Consultants, Jefferson Wells and Elan. ...
Belleayre Shows Its Appreciation Jan 12, 2006
OnTheSnow.com, Consumer demo days are Saturday and Sunday, with reps from Atomic, Blizzard, Elan and Dynastar on hand to hypnotize you with their latest gear. ...
Elan to Present at Healthcare Conferences in January 2006 Dec 22, 2005
PharmaLive.com (press release), DUBLIN, Ireland--(BUSINESS WIRE)--Dec 22, 2005 - Elan Corporation, plc announces that it will present at two healthcare conferences in January 2006. ...
Elan to Present at Healthcare Conferences in January 2006 Dec 22, 2005
Genetic Engineering News, On January 5, 2006, Elan will present at the Morgan Stanley Pharmaceutical CEO's Unplugged Conference in New York at 8:00 am Eastern Standard Time (EST), 1 ...
XM-R3 Triple Satellite Audio Receiver From ELAN Home Systems Now ... Dec 14, 2005
eHomeUpgrade, ELAN® Home Systems, a leading manufacturer of award-winning Multi-Room audio/video and home control systems, announced today that the company has begun ...
UPDATE 1-Wyeth plans trials of 3 Alzheimer drugs in 2006 Jan 13, 2006
Reuters The two other Wyeth medicines already in human trials are being developed under a 50/50 partnership with Irish drugmaker Elan Corp. ...
Winemakers begin to take advantage of court ruling Jan 12, 2006
Bothell Herald, For a small winery such as Elan, which makes about 1,000 cases a year, being able to ship is crucial, said owner Linda Elliott-Smith, who has had 15 cases of ...
Former National City, KeyCorp execs form new manager Jan 11, 2006
Pensions & Investments, Giesen. Mr. Giesen will be joined by former National City colleagues Mitchell Krahe and Ori Elan. Mr ... Messrs. Giesen and Elan. The ...
News In Brief Jan 11, 2006
Unison.ie, ELAN has entered into a licensing agreement in which EntreMed will use its nanocrystal technology to develop its oncology drug Panzem. ...
What's your winter wonderland? Jan 10, 2006
ic Wales, The usual suspects of Snowdon, Gower and the Elan Valley featured strongly but it was Tenby that was declared the surprise winner in terms of votes cast. ...
Biogen: FDA to rule on Tysabri Jan 10, 2006
MarketWatch Biogen and partner Elan Pharmaceuticals voluntarily pulled Tysabri from the market in February 2005 after three cases of PML were reported. ...
European Stocks Fall in Week; Stoxx 600 Snaps 11-Week Advance Jan 14, 2006
Bloomberg Standard & Poor's raised its outlook on the company's debt to stable from negative on better earnings prospects. Elan Corp. surged 13 percent to 13.14 euros. ...
Volunteer Opportunities Jan 13, 2006
Boston Globe, ...and Brockton. Please contact Elan Babchuck at 617-457-8669 or ebabchuck@jcrcboston.org. MATCH-UP Interfaith Volunteers Inc. needs ...
Injury time looms on Big Brother Jan 14, 2006
Telegraph.co.uk, ...nightmares. No Englishman would have survived them, and I hope his dignity and elan continue to put us to shame for years to come.
Where does the other half live? Jan 14, 2006
Unison.ie, ...addresses. Kelly Martin, the former Merrill Lynch investment banker who runs Elan, gives his address as 1040 Fifth Avenue, New York. ...
Top tournament in North Wales Jan 14, 2006
Wrexham Evening Leader, Ruthin have four players with Sioned Roberts and Elan Iorwerth in the under 16s and Llyr Iorwerth and Sarah Delonger in the 18s. ...
Hate the old kitchen? Love the new one Jan 14, 2006
DesMoinesRegister.com, Davis suggested the heavy, comfortable bar chairs from Elan Contemporary Furnishings in Omaha that surround the eating part of the kitchen island. ...
ISEQ breaches 7500 threshold Jan 9, 2006
Ireland Online, AIB rose 4c to €18.49 and Bank of Ireland rose 1c to €13.83. Pharmaceutical company Elan also recorded heavy gains, finishing up 36c to €12.02. ...
ISEQ falls just short of 7500 mark Jan 11, 2006
Ireland Online, The Dublin market closed up 71.41 points at 7494.37 as Elan led the charge, up 69c, almost 6%, to €12.55. It was a mostly positive day for the financials. ...
10.45am Markets Update Jan 10, 2006
RTE.ie, Shares in Ryanair were down 11 cent to €7.98 after a broker downgrade, while Elan shares lost 12 cent to stand at €11.90 after it announced a new ...
Schaeffer's Top and Bottom Ranked Stocks (CEPH, ELN, HSY) Jan 9, 2006
Schaeffers Research, ...trading opportunities. The stocks appearing on today's list of top and bottom ranked stocks are Cephalon, Elan, and Hershey. Not ...
Live at MacWorld: EVDO to Upgrade for MacBook Pro Jan 11, 2006
Gizmodo.com, ...updated as news comes in. The EVDOinfo forum reports a USB 2.0 dongle sold by Elan Digital Systems. EVDOinfo’s ExpressCard page ...
New drugs use saliva to help relieve pain Jan 10, 2006
Auburn Citizen, ...about. Recently, new drugs have been added to the market, exenatides (Byetta/Amylin Lilly) and ziconotides (Prialt/Elan). These ...
Irish stock exchange on course to be European favourite Dec 31, 2005
The Sunday Times, The main laggards were: Elan, where concerns over Tysabri affected investor sentiment; Waterford Wedgwood, which was dogged by weak sales in America; and Iona ...
2005 Gave Nanotech Investors Plenty to Chew On Jan 6, 2006
Motley Fool American Pharmaceutical's success was closely followed by an announcement that Roche had signed a deal with Elan (NYSE: ELN) to apply Elan's nanocrystal ...
Sharewatch: Desmond piles up the chips on Amarin’s march to ... Dec 31, 2005
The Sunday Times, The drug development company spun out of Elan raised $26.4m (€22.3m) just days before Christmas to fund what it hopes will be the final phase of trials for ...
CES Day Two: Must-Haves For Homebodies Jan 6, 2006
KLAS-TV, ...all into one system.". Elan's home systems aren't just for the rich and famous building a brand new custom home. "About 50-percent ...
UK Stocks Climb, Paced by Royal Bank of Scotland; P&O Surges Jan 11, 2006
Bloomberg Ireland's ISEQ Overall Index gained 0.8 percent to 7481.25, buoyed by shares of Elan Corp. ... Shares of Elan increased 3.7 percent to 12.3 euros in Dublin. ...
Joshi, Dhruv in title clash Jan 13, 2006
Rediff, In the semi-finals, Maharashtra's Joshi, potting with elan, displayed silken touch to wallop Rupesh Shah of Gujarat 1498-832, while promising Dhruv halted the ...
Brockton girls are doubles trouble Jan 12, 2006
Boston Globe, Bay Independent: With 10 seconds left in regulation, junior Elan Ziff (15 points) made two free throws to give Gann (3-4) a 56-54 victory over BU Academy. ...
Rivals Laying Siege to Amgen's Near Monopoly in Anemia Drugs Dec 23, 2005
The Ledger, Amgen's next challenge will come from Roche, which already sells a version of EPO, called NeoRecormon, in Europe based on patents obtained there by Genetics ...
Computer Modeling Suggests Cost-Effectiveness of Once Weekly ... Jan 13, 2006
Cancer Consultants (press release), Aranesp is a new erythropoiesis-stimulating protein that has a longer half-life than rHuEPO (Procrit®) and can be administered less frequently. ...
A new meaning of ‘giving’ Jan 13, 2006
Cincinnati Catholic Telegraph, She is not on dialysis but does receive regular Procrit shots and iron supplements delivered intravenously to keep her one kidney functioning at its current ...
A Biotech Battle Royal Dec 22, 2005
New York Times, Collectively, they will spend about $7 billion this year for Epogen and Aranesp and for the Johnson & Johnson drug Procrit, which is sold under license from ...
Amgen CEO expects more Epogen patent battles Jan 9, 2006
Reuters ...conference have been speculating that Johnson & Johnson (JNJ.N: Quote, Profile, Research), which has rights to sell Epogen under the brand name Procrit in the ...
Amgen patent attacked Dec 24, 2005
Los Angeles Daily News, Collectively, they will spend more than $7 billion this year for Epogen and Aranesp and for Johnson & Johnson's Procrit, which is sold under license from Amgen ...
Medicare expands tier pricing system Jan 3, 2006
USA Today ...of the cost of the drug rather than a flat dollar amount — are such expensive treatments as Remicade and Enbrel for rheumatoid arthritis, Procrit and Aranesp ...
Drug business making Johnson & Johnson sluggish Dec 18, 2005
Chicago Tribune, Big seller Procrit is losing share to Amgen's competing anemia drugs, and new generic challengers have emerged for such products as the Duragesic patch for ...
'Normal weekend' for police, fire Dec 26, 2005
Jacksonville Daily News, Southeastern Nephrology Associates on Doctors Drive in Jacksonville was broken into and a medication called Procrit was stolen. ...
TPG Ventures benoemt Simba Gill, Ph.D. tot partner en intern ... Dec 20, 2005
Netherlands Corporate News (persbericht), These positions included joint Global Product Manager for its lead therapeutic product Recormon as well as being part of the leadership team that developed and ...
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