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Enprofylline
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DRUG INFO
Enprofylline
Drug Name:
Enprofylline
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Indication: For management of symptoms of Asthma
Pharmacology: Enprofylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mechanism Of Action: Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. Enprofylline also binds to the adenosine A(2B) receptor which prevents adenosine induced bronchoconstriction.
Drug Category: Antiarrhythmic Agents; Anti-asthmatic Agents; Bronchodilator Agents; Anti-inflammatory Agents;
Brand Names/Synonyms: A018; D-4028; ENPROFYLLINE; Enprofilina [Inn-Spanish]; Enprofylline [Usan:Inn]; Enprofyllinum [Inn-Latin]; Nilyph; Oxeze
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 3-propyl-3,7-dihydropurine-2,6-dione
Chemical Formula: C8H10N4O2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00273
CAS Registry Number: 41078-02-8
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