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Enoxaparin
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DRUG INFO
Enoxaparin
Drug Name:
Enoxaparin
Indication: For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism
Pharmacology: Enoxaparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Enoxaparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Enoxaparin is a well known and commonly used anticoagulant which has antithrombotic properties. Enoxaparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Enoxaparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Enoxaparin acts at multiple sites in the normal coagulation system. Small amounts of Enoxaparin in combination with antithrombin III (Enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of Enoxaparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Enoxaparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Mechanism Of Action: The mechanism of action of Enoxaparin is antithrombin-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of Enoxaparin is well correlated to the inhibition of factor Xa. Enoxaparin interacts with Antithrombin III, Prothrombin and Factor X.
Drug Category: Fibrinolytic Agents; Anticoagulants; Heparins; ATC:B01AB05
Brand Names/Synonyms: Enoxaparin; Enoxaparin Sodium; Heparin; Heparin Sodium; Heparin Sodium Salt; Lovenox; Lovenox Hp; Low Molecular Weight Heparin Sodium
Dosage Forms: Solution for subcutaneous injection
Absorption: ~100% following subcutaneous injection
Interactions:
DrugBank: Interactions for Enoxaparin
Interactions for Enoxaparin:
Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation
of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including
acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If
co-administration is essential, conduct close clinical and laboratory monitoring.
Chemical IUPAC Name: 6-[5-acetylamino-4,6-dihydroxy-2-(sulfooxymethyl)tetrahydropyran-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxy-tetrahydropyran-2-yl)oxy-6-(hydroxymethyl)-3-sulfoamino-4-sulfooxy-tetrahydropyran-2-yl]oxy-4-hydroxy-5-sulfooxy-tetrahydropyran-2-carboxylicacid
Chemical Formula: (C26H40N2O36S5)n
Half Life: 4.5 hours
Drug Type: Approved Drug
# Accession No: APRD00068
CAS Registry Number: 9005-49-6
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Enoxaparin News
(When available)
Sharon's treatment after stroke questioned Jan 12, 2006
Miami Herald, ...said caused Sharon's first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States. But some experts questioned ...
Sharon's Treatment After Stroke Questioned Jan 12, 2006
ABC News ...hole in Sharon's heart they said caused Sharon's first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States.
Cerebral Amyloid Angiopathy, Found in Sharon, Explains Many ... Jan 13, 2006
MedPage Today, ...of CAA is usually contraindicated, but Sharon’s doctors gave him Clexane (enoxaparin), a low-molecular-weight heparin that is marketed as Lovenox in the US ...
SCCM: Heparin-Xigris Duo Appears Safe for Sepsis Jan 13, 2006
MedPage Today, XPRESS (Xigris and Prophylactic Heparin in Severe Sepsis trial, 976 patients were given Xigris plus unfractionated heparin or enoxaparin (Lovenox) and 959 ...
Debate intensifies over Sharon doctors’ decisions Jan 13, 2006
Corvallis Gazette Times, ...caused Sharon’s first stroke. Clexane, or enoxaparin, is sold as Lovenox in the United States. But some experts questioned that ...
More flow for antithrombotics Dec 30, 2005
Med Ad News (subscription), Promising new drugs are being developed as potential successors to the blockbuster brands Plavix and Lovenox. by Gina-Louise Monari. ...
Blood-Thinning Drugs Raise Alarm in Stroke Victims Jan 6, 2006
ABC News ...as potent as the thinner Coumadin. Clexane is sold in the United States under the name Lovenox. Sharon was on Clexane while waiting ...
Preventing The Pandemic Jan 3, 2006
BusinessWeek 2004, to $9.8 billion, on sales of $30.4 billion, said most of that growth was fueled by top-selling nonvaccine drugs such as blood thinner Lovenox and cancer ...
Small-Caps: 2005 Winners And Losers Jan 5, 2006
Forbes If it gets the green light from the FDA, Momenta's generic version of Lovenox, used in the prevention and treatment of deep vein thrombosis and treatment of ...
Sanofi Global Leader In Vaccines -Bernstein Dec 15, 2005
New Ratings Says Sanofi's vaccines business is more important than US patent risks on Plavix and Lovenox. Rates Sanofi outperform with a price target of EUR85. ...
Sharon to undergo heart procedure Dec 26, 2005
Houston Chronicle, Sharon is now getting an injection of Clexane, a blood-thinning medication called Lovenox in the United States, twice a day until the heart procedure, Lotem ...
Cerebral Amyloid Angiopathy, Found in Sharon, Explains Many ... Jan 13, 2006
MedPage Today, ...blood thinners in the presence of CAA is usually contraindicated, but Sharon’s doctors gave him Clexane (enoxaparin), a low-molecular-weight heparin that is ...
Study probes heart attacks, overdoses Jan 2, 2006
KVUE (subscription), Those given too much of two newer blood thinners - low molecular weight heparin and drugs sometimes called "super-aspirin" - had more than a 30 percent ...
Dosing Of Antiplatelet And Antithrombin Drugs Often Too High Dec 28, 2005
CNN The drugs were unfractionated heparin, low-molecular weight heparin, and glycoprotein IIb/IIIa inhibitors, wrote Dr. Alexander and colleagues. ...
Wrong Dose for Heart Attack Patients Dec 31, 2005
HeartZine, According to the study, the low molecular weight heparin and drugs commonly known as “super aspirin� are usually given as anti-clotting drugs to the heart ...
Study of Heart Attacks Finds Risk in Use of Blood Thinners Dec 27, 2005
New York Times, Those given extra amounts of two blood thinners - low molecular weight heparin and glycoprotein IIb/IIIa blockers, which are sometimes called super-aspirin ...
Heart Attack Patients Often Given Overdoses in ER Dec 28, 2005
Newsinferno.com, The drugs that were included in the study were heparin, low molecular weight heparin, and glycoprotein IIb-IIIa blockers, often called "super-aspirins" for ...
Excessive doses of antithrombotic therapy in patients with acute ... Dec 27, 2005
Xagena.it, The drugs in question – unfractionated Heparin ( UFH ), low-molecular-weight Heparin ( LMWH ) and glycoprotein IIb/IIIa inhibitors – work by either ...
Blood-thinner dose errors can cause bleeding:study Dec 27, 2005
Reuters The dosing errors with three classes of blood thinners -- unfractionated heparin, low-molecular-weight heparin and glycoprotein IIb/IIIa inhibitors -- most ...
Study: 42 percent get wrong dose of emergency drugs Dec 27, 2005
Winston-Salem Journal, The team studied the use of three commonly prescribed heart-attack drugs: unfractionated heparin, low-molecular-weight heparin and glycoprotein inhibitors ...
Medicure Announces Expansion of Antithrombotic Collaboration Jan 5, 2006
CCNMatthews (press release), He is recognized for his role in the preclinical development and initiating the first clinical trials of low-molecular-weight heparin and antithrombin agents ...
Misdosing Common For Powerful Anti-clotting Drugs Dec 28, 2005
Science Daily (press release) The drugs in question – unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and glycoprotein IIb/IIIa inhibitors – work by either preventing ...
Study: Heart-attack drugs misused Dec 28, 2005
Arkansas Democrat-Gazette (subscription), They studied use of three commonly-prescribed heart-attack drugs: unfractionated heparin, low-molecular-weight heparin and glycoprotein inhibitors, which work ...
Too high blood-thinner doses harmful to patients Dec 29, 2005
News-Medical.net, The study says the dosing errors involving three classes of blood thinners, unfractionated heparin, low-molecular-weight heparin and glycoprotein IIb/IIIa ...
Duke: ERs often give wrong doses of blood-clotting drug Dec 29, 2005
Bizjournals.com, The drugs in question include unfractionated heparin (UHF), low-molecular-weight heparin (LMWH) and glycoprotein IIb/IIIa inhibitors, all of which work by ...
Aspirin Reduces Thrombosis Risk with Thalidomide-Anthracycline ... Dec 23, 2005
Cancerpage.com, ..."Further studies should be explored to compare low-dose aspirin with other strategies (low-molecular-weight heparin and therapeutic intensity anticoagulation ...
CARDIAC PATIENTS GETTING DRUG OD Dec 28, 2005
New York Post, Those given too much of two newer blood thinners — low molecular-weight heparin and drugs sometimes called "super-aspirin" — had more than a 30 percent ...
This Week in Health Dec 30, 2005
Intelihealth.com, The patients who got too much of the newer blood thinners, such as low molecular weight heparin and "super aspirin," had a 30% greater risk of serious bleeding ...
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