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Encainide
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DRUG INFO
Encainide
Drug Name:
Encainide
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Indication: For management of irregular heartbeats to a normal rhythm
Pharmacology: Used to treat irregular heartbeats. Encainide decreases excitability, conduction velocity, and automaticity as a result of slowed atrial, atrioventricular (AV) nodal, His-Purkinje, and intraventricular conduction. It causes a slight but significant prolongation of refractory periods in these tissues. The greatest effect is on the His-Purkinje system. Encainide decreases the rate of rise of the action potential without markedly affecting its duration.
Mechanism Of Action: Encainide is a sodium channel blocker, binding to voltage gated sodium channels. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole.
Drug Category: Antiarrhythmic Agents; ATC:C01BC08
Brand Names/Synonyms: Encainida [Spanish]; Encainide; Encainide [French]; Encainidum [Latin]; Enkaid; MJ 9067; None
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 4-methoxy-N-[2-[1-methyl-2-(1-piperidyl)ethyl]phenyl]-benzamide
Chemical Formula: C22H28N2O2
Half Life: 1-2 hours
Drug Type: Approved Drug
# Accession No: APRD00613
CAS Registry Number: 66778-36-7
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