Indication: For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina
Pharmacology: Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.
Mechanism Of Action: Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.
Drug Category: Vasodilator Agents; Vasodilator Agents; ATC:B01AC07
Interactions:
DrugBank: Interactions for Dipyridamole
Interactions for Dipyridamole:
No pharmacokinetic drug-drug interaction studies were conducted with PERSANTINE® (dipyridamole USP) Tablets.
The following information was obtained from the literature.
Adenosine: Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of
adenosine. Adjustment of adenosine dosage may be necessary.
Cholinesterase Inhibitors: Dipyridamole may counteract the anticholinesterase effect of cholinesterase
inhibitors, thereby potentially aggravating myasthenia gravis.
Chemical IUPAC Name: 2-[[3-[bis(2-hydroxyethyl)amino]-5,10-bis(1-piperidyl)-2,4,7,9-tetrazabicyclo[4.4.0]deca-2,4,7,9,11-pentaen-8-yl]-(2-hydroxyethyl)amino]ethanol
Chemical Formula: C24H40N8O4
Half Life: 40 minutes
Drug Type: Approved Drug
# Accession No: APRD00360
CAS Registry Number: 58-32-2
Dipyridamole News (When available)
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John Oncken: Keller dairy operation all in the familyDec 15, 2005 The Capital Times, ...nutritionist with Irv Feed and Supplies of Mount Horeb making the ration; Paul Lawinger of Amcore Bank in Mount Horeb is their banker; Sandy Curan of Madison ...
Transcript of Paul Posluszny/Levi Brown Press ConferenceJan 13, 2006 GoPSUsports.com I wear this brace and do exercises here and there and a lot of therapy sitting in a cold tub and getting stim and ultrasound put on my knee and things like that ...
State Taking Applications For Training ProgramJan 6, 2006 Hartford Courant, Project manager Ed Stim said the companies also must have billed at least $500,000 in contracts during the preceding 24-month period. ...
Ten best career books for 2005Jan 2, 2006 Sun-Sentinel.com, ...more volatile. Whoops! I'm in Business: A Crash Course in Business Basics by Richard Stim and Lisa Guerin (Nolo). Readers who savor ...
Unreal Tournament 2004Dec 18, 2005 4players, Any music with "AllowStim" at the end of the song title can be played alongside a Stim. No longer able to carry two SIZE_Large items. ...
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